ITGAM
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Official Full Name
integrin, alpha M (complement component 3 receptor 3 subunit)
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Overview
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Others
- Human
- Mouse
- Rat
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cells
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- ITGAM Related Articles
- ITGAM Related Research Area
ITGAM involved in several pathways and played different roles in them. We selected most pathways ITGAM participated on our site, such as Rap signaling pathway, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Rap signaling pathway | ACTG1;MAPK3;ITGB2L;LPAR4;PLCB2;FGF20;RAC1;MAP2K1;Itgam&Itgb2 |
Phagosome | THBS2;TFRC;TUBB;SEC61G;SFTPA1;HLA-DRA;ITGB1;FCGR3;ATP6V1G2 |
Cell adhesion molecules (CAMs) | PVRL3;CLDN22;MPZL1L;CLDNK;CNTNAP2;CD80;PTPRC;NRXN1A;PTPRF |
Hematopoietic cell lineage | IL6;HLA-DRA;CD3G;CD9;CD14;CD36;IL1B;CR2;IL11RA |
Leukocyte transendothelial migration | CLDN15;CLDN23;PTK2B;ACTN1;NIPAL1;MAPK12;PTPN11;NCF4;CLDN6 |
Regulation of actin cytoskeleton | MYLK;MYL12.1;ARHGEF7B;RAC1;MYL2;ARPC5B;ITGA5;BDKRB2;FGF18 |
Pertussis | AMCF-II;CFL2;MAPK8;IRF1;ITGB2;IL-8;MAPK3;C4BPB;IL12B |
Legionellosis | CXCL1;MYD88;ITGB2L;HSPD1;EEF1G;IL12A;SEC22B;C3;HBS1L |
Leishmaniasis | HLA-DRB5;HLA-DPA1;NFKB1;FCGR3;PTGS2;FCGR3B;IL1B;IL12A;ITGA4 |
Amoebiasis | ITGB2L;ACTN2;PLCB2;PIK3R1;IL12B;C8A;SERPINB6B;GNA14;CD14 |
Staphylococcus aureus infection | FCGR1A;C5AR1;HLA-DRB4;HLA-DOB;H2-AB1;FPR2;FCGR2C;PLG;HLA-DQB1 |
Tuberculosis | TLR1;Pla2r1;SPHK2;Il23a; Il12b;ATP6V0A1;LAMP2;CALM2;IFNA17;CAMK2A |
Transcriptional misregulation in cancer | PFTK1;MET;SS18;ATF1;RUNX1T1;TLX1;MDM2;EYA1;MLLT1 |
ITGAM has several biochemical functions, for example, glycoprotein binding, heparan sulfate proteoglycan binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAM itself. We selected most functions ITGAM had, and list some proteins which have the same functions with ITGAM. You can find most of the proteins on our site.
Function | Related Protein |
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glycoprotein binding | Serpina1c;SDC1;APOH;CNTN2;THBS1;FYN;FOXRED2;HSPA5;ITGA3 |
heparan sulfate proteoglycan binding | Gpc2;PLA2G2D;GPC4;SLIT2;AZU1;SEMA5A;ITGAM;UBE4A;GPC5A |
heparin binding | TGFBR3;VEGFA;NRP1;CTGFB;PCOLCE2;RSPO2;CCL23;FGFBP3;LIPI |
metal ion binding | JMJD5;ZNF548;Ar;Reln;MUS81;RUNX1T1;MARCH6;NAIP6;ARAP2 |
opsonin binding | Itgam&Itgb2;ITGAM;CLEC7A |
protein binding | PPP1CC;CGGBP1;TIPIN;PRDX4;USP15;RAB39B;DUT;MPP7;PKN2 |
ITGAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAM here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAM.
CLEC4M; fibrinogen_human_complex; crlkekhc
- Q&As
- Reviews
Q&As (7)
Ask a questionIt facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.
Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.
Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.
ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.
ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.
ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.
Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.
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