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Official Full Name cell division cycle 45 homolog (S. cerevisiae)
Background The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms CDC45L; CDC45L2; PORC-PI-1; cell division control protein 45 homolog; human CDC45; OTTHUMP00000197247; OTTHUMP00000197248; CDC45-related protein; cell division cycle 45-like 2; CDC45 cell division cycle 45 homolog; CDC45; cell division cycle 45 homolog (S. cerevisiae)
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDC45-5135H Recombinant Human CDC45 Protein, GST-tagged Wheat Germ GST
    Human CDC45-7649HCL Recombinant Human CDC45 293 Cell Lysate HEK293 N/A
    Human CDC45-768H Recombinant Human CDC45 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cdc45-857M Recombinant Mouse Cdc45 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Zebrafish CDC45-12563Z Recombinant Zebrafish CDC45 Mammalian Cell His

    cdc45 involved in several pathways and played different roles in them. We selected most pathways cdc45 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdc45 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle ANAPC13; E2F2; MAPRE1; DNA2; CDC25C; CCNB2; ERCC6L; ARF1; GINS2; RCC2

    cdc45 has several biochemical functions, for example, 3-5 DNA helicase activity, DNA replication origin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cdc45 itself. We selected most functions cdc45 had, and list some proteins which have the same functions with cdc45. You can find most of the proteins on our site.

    Function Related Protein
    3-5 DNA helicase activity WRN; CDC45; GINS1; ERCC3; FBXO18
    DNA replication origin binding ORC4; MCM10; ORC4L; ORC2L; CDC45; HSPD1; MCM2; MCM5; ORC3L
    chromatin binding NCAPD3; PHF21B; LOXL2; ASF1A; SMAD6; TRP63; ARID3C; MLH3; NUP62; PBX2
    protein binding ARL14; CREBZF; LCP2; ACAD9; DPYSL2; TLR13; WWOX; PROM1; KIF20B; EPHB4
    single-stranded DNA binding NABP1; RTF1; RPA3; DMC1; CNBPA; LONP1; PCBP1; LRPPRC; NABP2; SSBP1

    cdc45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdc45 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdc45.


    Takaya, J; Kusunoki, S; et al. Protein interaction and cellular localization of human CDC45. JOURNAL OF BIOCHEMISTRY 153:381-388(2013).
    Nagahama, Y; Ueno, M; et al. PSF3 marks malignant colon cancer and has a role in cancer cell proliferation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392:150-154(2010).

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