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CDC45

Official Full Name

cell division cycle 45 homolog (S. cerevisiae)
Overview

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

CDC45L; CDC45L2; PORC-PI-1; cell division control protein 45 homolog; human CDC45; OTTHUMP00000197247; OTTHUMP00000197248; CDC45-related protein; cell division cycle 45-like 2; CDC45 cell division cycle 45 homolog; CDC45; cell division cycle 45 homolog (S. cerevisiae);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDC45-5135H	Recombinant Human CDC45 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CDC45-7649HCL	Recombinant Human CDC45 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CDC45-768H	Recombinant Human CDC45 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CDC45-2085HFL	Recombinant Full Length Human CDC45 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	CDC45-3755HF	Recombinant Full Length Human CDC45 Protein, GST-tagged	In Vitro Cell Free System	GST	566 amino acids	Inquiry
Human	CDC45-556H-B	Recombinant Human CDC45 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	CDC45-556H	Recombinant Human CDC45 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Cdc45-857M	Recombinant Mouse Cdc45 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Zebrafish	CDC45-12563Z	Recombinant Zebrafish CDC45	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CDC45 Related Articles

CDC45 involved in several pathways and played different roles in them. We selected most pathways CDC45 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC45 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	SKA1;WEE1;MCM8;TUBGCP2;YWHAQB;CEP78;CEP72;SPC25;CDCA5

CDC45 has several biochemical functions, for example, 3-5 DNA helicase activity, DNA replication origin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC45 itself. We selected most functions CDC45 had, and list some proteins which have the same functions with CDC45. You can find most of the proteins on our site.

Function	Related Protein
3-5 DNA helicase activity	CDC45;GINS1;WRN;ERCC3;FBXO18
DNA replication origin binding	CDC45;ORC4;HSPD1;MCM10;ORC2L;MCM2;ORC4L;ORC3L;MCM5
chromatin binding	CDCA5;LMO2;PAX3;FEZF2;SMC3;C19orf40;TOX2;GPR30;SUV39H1
protein binding	DSC2;ST6GAL1;DVL1;ZNF155;DDR1;SPRR2A;PPCDC;TMEM218;RRP7A
single-stranded DNA binding	SSBP4;POLR2GL;NABP1A;MCM7;RAD51B;SWSAP1;DDX11;CDAN1;SSBP1

CDC45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC45 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC45.

CDKN1A; RPA2; CLSPN; CEP55; TOPBP1; ORC5

Takaya, J; Kusunoki, S; et al. Protein interaction and cellular localization of human CDC45. JOURNAL OF BIOCHEMISTRY 153:381-388(2013).

Nagahama, Y; Ueno, M; et al. PSF3 marks malignant colon cancer and has a role in cancer cell proliferation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392:150-154(2010).