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CDC5L

Official Full Name

cell division cycle 5-like
Overview

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Synonyms

CDC5L; cell division cycle 5-like; CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; cell division cycle 5-like protein; Cdc5-related protein; pombe cdc5-related protein; dJ319D22.1 (CDC5-like protein); CDC5 cell division cycle 5-like;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDC5L-11017H	Recombinant Human CDC5L, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25ug
Human	CDC5L-0954H	Recombinant Human CDC5L Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CDC5L-7648HCL	Recombinant Human CDC5L 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CDC5L-803H	Recombinant Human CDC5L Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CDC5L-3105HF	Recombinant Full Length Human CDC5L Protein, GST-tagged	In Vitro Cell Free System	GST	802 amino acids	Inquiry
Mouse	Cdc5l-2079M	Recombinant Mouse Cdc5l Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	CDC5L-769R	Recombinant Rhesus monkey CDC5L Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CDC5L-595R	Recombinant Rhesus Macaque CDC5L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CDC5L-595R-B	Recombinant Rhesus Macaque CDC5L Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CDC5L-11308Z	Recombinant Zebrafish CDC5L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CDC5L Related Articles

CDC5L involved in several pathways and played different roles in them. We selected most pathways CDC5L participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC5L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Spliceosome	NHP2L1;PRPF3;SNRNP70;SNRPD3;HSPA1B;PPIL1;SF3B3;U2AF1L4;PRP19

CDC5L has several biochemical functions, for example, DNA binding, WD40-repeat domain binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC5L itself. We selected most functions CDC5L had, and list some proteins which have the same functions with CDC5L. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ANKRD1;ZNF684;ZNF710;FOXL1;ZNF383;CREM;KHSRP;NEUROD6A;FOXC1
WD40-repeat domain binding	CDC5L;USP47;MYB
poly(A) RNA binding	POP1;ZRANB2;SRPK1;FASTKD3;HNRNPH2;SMC1A;SAP18;SLC16A3;ALKBH5
protein binding	NPHP4;MLH3;EPB41;PURA;ATP5F1;CDK2;IGFBP7;ADAMTSL3;UBE2C

CDC5L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC5L here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC5L.

PLRG1; HNRNPM; TTF2; YWHAG; ORC2; GOLGA2

Ganesh, K; van Maldegem, F; et al. Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha. FEBS LETTERS 588:21-27(2014).

Ganesh, K; Adam, S; et al. CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31. JOURNAL OF BIOLOGICAL CHEMISTRY 286:17091-17102(2011).

Conticello, SG; Ganesh, K; et al. Interaction between anti body-diversification enzyme AID and spliceosome-associated factor CTNNBL1. MOLECULAR CELL 31:474-484(2008).

Ajuh, P; Kuster, B; et al. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. EMBO JOURNAL 19:6569-6581(2000).