clcn4

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clcn4

Official Full Name chloride channel, voltage-sensitive 4
Background The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.
Synonyms CLCN4; chloride channel, voltage-sensitive 4; chloride channel 4; H(+)/Cl(-) exchange transporter 4; ClC 4; CLC4; chloride channel protein 4; chloride transporter ClC-4; ClC-4; ClC-4A; MGC163150; Clc4-2
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLCN4-7474HCL Recombinant Human CLCN4 293 Cell Lysate HEK293 N/A
    Mouse CLCN4-2-3515M Recombinant Mouse CLCN4-2 Protein Mammalian Cell His
    Zebrafish CLCN4-4679Z Recombinant Zebrafish CLCN4 Mammalian Cell His

    clcn4 involved in several pathways and played different roles in them. We selected most pathways clcn4 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with clcn4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport TRPV3; TRPA1A; ANO4; ATP1A1A.3; TRPM1B; SLC9B2; TRPC6A; TPCN1; SGK2; TTYH3
    Stimuli-sensing channels TTYH1; ANO5B; SLC17A3; ANO5; BEST4; BEST3; ANO10A; ANO4; CLCNKA; OSTM1
    Transmembrane transport of small molecules SLC6A6; SLC6A20; SLC29A3; SLC6A11; ADD3B; TRPA1A; FTH1B; OSTM1; SLC1A2A; TFR1B

    clcn4 has several biochemical functions, for example, ATP binding, antiporter activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by clcn4 itself. We selected most functions clcn4 had, and list some proteins which have the same functions with clcn4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PTK2BB; MAP3K1; IGHMBP2; SUCLA2; PFKFB2; UBA7; MAP3K13; SMC6; CHORDC1; NTRK2
    antiporter activity SLC35D1B; SLC9A6B; SLC38A3; CLCN4-2; SLC7A4; SLC7A5; SLC25A16; SLC7A8; SLC7A13; SLC35C2
    chloride channel activity SLC26A11; TTYH2L; CLIC1; GABRR1; CLCN3; ANO2; CLCC1; GABRD; SLC26A3; FXYD3
    voltage-gated chloride channel activity CLCN5; CLCN1; CLCN1A; CLCN7; CLCN3; ANO6; CLCNKA; CLCNK; CLCN4; CLCN4-2

    clcn4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clcn4 here. Most of them are supplied by our site. Hope this information will be useful for your research of clcn4.

    Johanneson, B; Chen, D; et al. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study. CARCINOGENESIS 35:2084-2088(2014).
    Wright, GWJ; Parsons, SP; et al. Cholinergic signalling-regulated K(V)7.5 currents are expressed in colonic ICC-IM but not ICC-MP. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 466:1805-1818(2014).

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