CLIC1 Protein


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Official Full Name chloride intracellular channel 1
Background Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
Synonyms CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP; hRNCC; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel pr
    • Species :
    • Bos taurus (Bovine)
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Oryctolagus cuniculus (Rabbit)
    • Rat
    • Rattus norvegicus (Rat)
    • Sus scrofa (Pig)
    • Zebrafish
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLIC1-11324H Recombinant Human CLIC1, GST-tagged E.coli GST
    Human CLIC1-1477H Recombinant Human CLIC1 Protein, GST-tagged Wheat Germ GST
    Human CLIC1-2498H Recombinant Human Chloride Intracellular Channel 1, His-tagged E.coli His
    Human CLIC1-262H Recombinant Human CLIC1, His-tagged E.coli His
    Human CLIC1-27814TH Recombinant Human CLIC1, His-tagged E.coli His
    Human CLIC1-27816TH Recombinant Human CLIC1, His-tagged E.coli His
    Rat CLIC1-1448R Recombinant Rat CLIC1 Protein Mammalian Cell His
    Zebrafish CLIC1-11958Z Recombinant Zebrafish CLIC1 Mammalian Cell His
    Human CLIC1-7448HCL Recombinant Human CLIC1 293 Cell Lysate HEK293 N/A
    Human CLIC1-2175HF Recombinant Full Length Human CLIC1 Protein, GST-tagged In Vitro Cell Free System GST
    Sus scrofa (Pig) RFL17585SF Recombinant Full Length Pig Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His
    Bos taurus (Bovine) RFL24437BF Recombinant Full Length Bovine Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His
    Oryctolagus cuniculus (Rabbit) RFL30084OF Recombinant Full Length Rabbit Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His
    Rattus norvegicus (Rat) RFL30330RF Recombinant Full Length Rat Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His
    Homo sapiens (Human) RFL35442HF Recombinant Full Length Human Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His
    Human CLIC1-5937H Recombinant Human CLIC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CLIC1-620H Recombinant Human CLIC1 Protein, His-tagged E.coli His
    Mouse Clic1-519M Recombinant Mouse Clic1 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    CLIC1 involved in several pathways and played different roles in them. We selected most pathways CLIC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    CLIC1 has several biochemical functions, for example, chloride channel activity, NOT glutathione transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIC1 itself. We selected most functions CLIC1 had, and list some proteins which have the same functions with CLIC1. You can find most of the proteins on our site.

    Function Related Protein
    chloride channel activity SLC1A4; GABRA1; CFTR; SLC26A4; GABRE; CLCN3; CLCNKB; CLCN1; GABRG2; SLC26A9
    NOT glutathione transferase activity CLIC3; CLIC1; CLIC5; CLIC2; ALOX5AP
    protein binding WRNIP1; KNG1; RMND5A; PRIMPOL; NUP98; FKBP6; EIF4EA; TUBA3D; ODF2; HTR3E
    voltage-gated ion channel activity TRPM5; KCNA2B; KCNJ1A.6; CACNA2D3; SCN12AB; TPC3; CACNG7A; CYBB; CACNA1DA; KCNJ16

    CLIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIC1.

    EPB41; MCC; HLA-B; ARF6; IKBKE; LSM1; RPLP1; THRA; ALOX5AP; ATP5F1; ATP6V0C; NTF4; NUP62; MLH1; CPT1A; PRDX4; rpoB; nifJ; hemH1

    Averaimo, S; Gritti, M; et al. CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells. JOURNAL OF NEUROCHEMISTRY 131:444-456(2014).
    Setti, M; Savalli, N; et al. Functional Role of CLIC1 Ion Channel in Glioblastoma-Derived Stem/Progenitor Cells. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1644-1655(2013).

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