CLIC1

  • Official Full Name

    chloride intracellular channel 1

  • Overview

    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
  • Synonyms

    CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP; hRNCC; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel pr;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLIC1-2498H Recombinant Human Chloride Intracellular Channel 1, His-tagged E.coli His
Human CLIC1-11324H Recombinant Human CLIC1, GST-tagged E.coli GST 1-241a.a.
Human CLIC1-27814TH Recombinant Human CLIC1, His-tagged E.coli His 241 amino acids
Human CLIC1-27816TH Recombinant Human CLIC1, His-tagged E.coli His
Human CLIC1-262H Recombinant Human CLIC1, His-tagged E.coli His Met1-Lys241
Human CLIC1-1477H Recombinant Human CLIC1 Protein, GST-tagged Wheat Germ GST
Human CLIC1-7448HCL Recombinant Human CLIC1 293 Cell Lysate HEK293 N/A
Human CLIC1-620H Recombinant Human CLIC1 Protein, His-tagged E.coli His Lys79~Lys241
Human CLIC1-5937H Recombinant Human CLIC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLIC1-2175HF Recombinant Full Length Human CLIC1 Protein, GST-tagged In Vitro Cell Free System GST 241 amino acids
Human CLIC1-1747H Recombinant Human CLIC1 Protein (Lys79-Lys241), His tagged E.coli His Lys79-Lys241
Mouse Clic1-519M Recombinant Mouse Clic1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CLIC1-1448R Recombinant Rat CLIC1 Protein Mammalian Cell His
Rat CLIC1-1106R Recombinant Rat CLIC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CLIC1-1106R-B Recombinant Rat CLIC1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL24437BF Recombinant Full Length Bovine Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-241)
Homo sapiens (Human) RFL35442HF Recombinant Full Length Human Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-241)
Oryctolagus cuniculus (Rabbit) RFL30084OF Recombinant Full Length Rabbit Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-241)
Rattus norvegicus (Rat) RFL30330RF Recombinant Full Length Rat Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-241)
Sus scrofa (Pig) RFL17585SF Recombinant Full Length Pig Chloride Intracellular Channel Protein 1(Clic1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-110)
Zebrafish CLIC1-11958Z Recombinant Zebrafish CLIC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CLIC1 involved in several pathways and played different roles in them. We selected most pathways CLIC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CLIC1 has several biochemical functions, for example, chloride channel activity, NOT glutathione transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIC1 itself. We selected most functions CLIC1 had, and list some proteins which have the same functions with CLIC1. You can find most of the proteins on our site.

Function Related Protein
chloride channel activitySLC26A6L;FXYD1;GABRP;CLCA1;CLCN7;SLC26A2;BEST1;FXYD3;CLIC6
NOT glutathione transferase activityCLIC5;CLIC3;ALOX5AP;CLIC1;CLIC2
protein bindingTJAP1;CLEC1B;JUP;PRSS2;KLHL3;MPZL3;TRAPPC10;HEY1;SERPING1
voltage-gated ion channel activityKCNJ1A.5;CACNA1BA;CLIC5;ANO6;CACNG2A;CATSPER2;KCNIP1;KCNJ11L;GPR89

CLIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIC1.

EPB41; MCC; HLA-B; ARF6; IKBKE; LSM1; RPLP1; THRA; ALOX5AP; ATP5F1; ATP6V0C; NTF4; NUP62; MLH1; CPT1A; PRDX4; rpoB; nifJ; hemH1

Research Area

Related articles

Averaimo, S; Gritti, M; et al. CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells. JOURNAL OF NEUROCHEMISTRY 131:444-456(2014).
Setti, M; Savalli, N; et al. Functional Role of CLIC1 Ion Channel in Glioblastoma-Derived Stem/Progenitor Cells. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1644-1655(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does CLIC1 protein contribute to cancer progression? 08/26/2021

CLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.

Are there any clinical trials targeting CLIC1 protein in cancer therapy? 07/23/2021

Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.

How does CLIC1 protein contribute to cardiovascular disorders? 12/09/2020

CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.

Can CLIC1 protein be used as a therapeutic target in neurodegenerative diseases? 12/01/2018

Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.

How is CLIC1 protein involved in neurodegenerative diseases? 09/20/2017

CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.

Customer Reviews (3)

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Reviews
12/12/2022

    With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

    07/26/2020

      Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

      11/04/2018

        Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.

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