Recombinant Human Chloride Intracellular Channel 1, His-tagged

Cat.No. : CLIC1-2498H
Product Overview : Recombinant human CLIC1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 29.0 kDa (261aa).
  • Specification
  • Gene Information
  • Related Products
Cat. No. : CLIC1-2498H
Description : CLIC1 (Chloride intracellular channel 1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. This protein is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as an anion-selective channel. It forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring.
Source : E.coli.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl.
Purity : > 90% by SDS – PAGE.
Concentration : 1.0 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K.
Storage : can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : CLIC1 chloride intracellular channel 1 [ Homo sapiens ]
Synonyms : chloride intracellular channel 1; G6; NCC27; CLIC1; chloride intracellular channel protein 1; hRNCC; p64CLCP; RNCC protein; OTTHUMP00000029133; OTTHUMP00000029137; OTTHUMP00000174486; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein;Chloride channel ABP; Nuclear chloride ion channel 27; Regulatory nuclear chloride ion channel protein
Gene ID : 1192
mRNA Refseq : NM_001288
Protein Refseq : NP_001279
MIM : 602872
UniProt ID : O00299
Chromosome Location : 6p22.1-p21.2
Function : chloride channel activity; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does CLIC1 protein contribute to cancer progression? 08/26/2021

CLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.

Are there any clinical trials targeting CLIC1 protein in cancer therapy? 07/23/2021

Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.

How does CLIC1 protein contribute to cardiovascular disorders? 12/09/2020

CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.

Can CLIC1 protein be used as a therapeutic target in neurodegenerative diseases? 12/01/2018

Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.

How is CLIC1 protein involved in neurodegenerative diseases? 09/20/2017

CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.

Customer Reviews (3)

Write a review
Reviews
12/12/2022

    With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

    07/26/2020

      Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

      11/04/2018

        Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.

        Ask a Question for All CLIC1 Products

        Required fields are marked with *

        My Review for All CLIC1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends