Recombinant Human CLIC1 Protein, His-tagged

• Cat.No.: CLIC1-620H
• Product Overview: Recombinant Human CLIC1(Lys79~Lys241) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Molecular Mass: 21.8kDa
• Protein length: Lys79~Lys241
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: CLIC1 chloride intracellular channel 1 [ Homo sapiens ]
• Official Symbol: CLIC1
• Synonyms: CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP; hRNCC; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein; G6
• Gene ID: 1192
• mRNA Refseq: NM_001288
• Protein Refseq: NP_001279
• MIM: 602872
• UniProt ID: O00299

Reviews

12/12/2022

With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

07/26/2020

Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

11/04/2018

Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.

Q&As

How does CLIC1 protein contribute to cancer progression?

CLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.

Are there any clinical trials targeting CLIC1 protein in cancer therapy?

Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.

How does CLIC1 protein contribute to cardiovascular disorders?

CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.

Can CLIC1 protein be used as a therapeutic target in neurodegenerative diseases?

Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.

How is CLIC1 protein involved in neurodegenerative diseases?

CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.