Recombinant Human CLIC1, His-tagged

• Cat.No.: CLIC1-262H
• Product Overview: A DNA sequence encoding the human CLIC1 (O00299) (Met1-Lys241) was expressed with a polyhistide tag at the N-terminus.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from sterile PBS, pH7.4.
• Molecular Mass: The recombinant human CLIC1 consists of 259 amino acids and predicts a molecular mass of 29.2 KDa. It migrates as an approximately 31-35 KDa band in SDS-PAGE under reducing conditions.
• Protein length: Met1-Lys241
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: CLIC1 chloride intracellular channel 1 [ Homo sapiens ]
• Official Symbol: CLIC1
• Synonyms: CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP; hRNCC; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein; G6
• Gene ID: 1192
• mRNA Refseq: NM_001288
• Protein Refseq: NP_001279
• MIM: 602872
• UniProt ID: O00299
• Chromosome Location: 6p21.3
• Function: chloride channel activity; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity

Reviews

12/12/2022

With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

07/26/2020

Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

11/04/2018

Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.

Q&As

How does CLIC1 protein contribute to cancer progression?

CLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.

Are there any clinical trials targeting CLIC1 protein in cancer therapy?

Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.

How does CLIC1 protein contribute to cardiovascular disorders?

CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.

Can CLIC1 protein be used as a therapeutic target in neurodegenerative diseases?

Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.

How is CLIC1 protein involved in neurodegenerative diseases?

CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.