CLIP1

  • Official Full Name

    CAP-GLY domain containing linker protein 1
  • Overview

    The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CLIP1;CAP-GLY domain containing linker protein 1;restin (Reed Steinberg cell expressed intermediate filament associated protein) , RSN;CAP-Gly domain-containing linker protein 1;CLIP;CLIP 170;CLIP170;CYLN1;restin;cytoplasmic linker protein 1;cyt
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLIP1-3582M Recombinant Mouse CLIP1 Protein Mammalian Cells Mouse His
CLIP1-6502C Recombinant Chicken CLIP1 Mammalian Cells Chicken His
CLIP1-1756M Recombinant Mouse CLIP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CLIP1-1756M-B Recombinant Mouse CLIP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CLIP1-2717H Recombinant Human CLIP1 protein(371-940 aa), C-His-tagged E.coli Human His 371-940 aa

    Involved Pathway

    CLIP1 involved in several pathways and played different roles in them. We selected most pathways CLIP1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitotic Metaphase and Anaphase SPC24,SKA1,SPDL1,CENPI,TMPO,NDEL1A,ITGB3BP,ERCC6L,RANGAP1B,CENPE
    Mitotic Anaphase NDEL1B,CENPO,CCDC99,CENPK,CENPH,NDEL1,WAPAL,VRK2,TMPO,CENPL
    Cell cycle KIF20A,NCAPH2,MAPRE1B,CCNE2,CDC25C,ARPP19B,ARPP19A,MCPH1,MCM9,YWHAG1
    Mitotic Prometaphase CDCA5,KNTC1,MIS12,CENPH,CDCA8,RANGAP1B,SKA1,NCAPH,SKA2,NCAPG
    RHO GTPase Effectors PRC1,KDM4C,NDEL1B,CIT,RANGAP1B,SKA1,DIAPH1,ABI1A,KTN1,WIPF2
    RHO GTPases Activate Formins SPDL1,SKA2,SPC25,NSL1,MKL1B,DSN1,SGOL2,NDEL1B,NUF2,ZWILCH
    Cell Cycle, Mitotic SGOL2,NEDD1,CEP72,GINS2,NCAPH2,SPC24,WAPAL,TSGA14,NUMA1,NEK6
    M Phase CENPL,NCAPG2,ENSAA,SGOL1,PDS5B,NUDC,NEK9,APITD1,CNEP1R1,B9D2

    Protein Function

    CLIP1 has several biochemical functions, for example, metal ion binding,microtubule binding,microtubule plus-end binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIP1 itself. We selected most functions CLIP1 had, and list some proteins which have the same functions with CLIP1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NUBP1,MOS,AKAP12,TIPIN,MRPL48,MFN1,TNFSF10,SNAI1,CCDC50,PDS5B
    microtubule plus-end binding APC,MAPRE1,KIF18A,CLASP1,DST,KIF2C,CLIP2,STIM1,CLASP1A
    metal ion binding PPM1NB,ZNF823,ATP2B1A,ZSCAN20,GM3258,ARSG,CYP8B1,NME3,PVALB3,TIMP2
    nucleic acid binding SP8B,RBFOX1L,GTF3AA,SETD1B,BLM,SRSF6B,HNRNPA0L,RBM4.2,ZFP13,ZSCAN4C
    tubulin binding EML2,IFT81,BIRC5,LRRK2,PRNP,TTLL6,STMN3,TPR,STMN1A,BRCA1
    microtubule binding KIF25,PPP5C,DPYSL5,MTAP1A,WDR43,KIFC1,KIFC2,KIF5B,WDR81,CEP350
    zinc ion binding ADH8B,LMO1,DPYS,RNF34,AGBL4,KPNB1,LPXN,ADAMTS1,GTF2B,APOBEC3G

    Interacting Protein

    CLIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIP1.

    Diaph1;Clasp1;Ywhae;Ywhab

    Resources

    References

    • Calligaris, D; Manatschal, C; et al. Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes. JOURNAL OF PROTEOMICS 75:3605-3616(2012).

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