CLIP1
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Official Full Name
CAP-GLY domain containing linker protein 1 -
Overview
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CLIP1;CAP-GLY domain containing linker protein 1;restin (Reed Steinberg cell expressed intermediate filament associated protein) , RSN;CAP-Gly domain-containing linker protein 1;CLIP;CLIP 170;CLIP170;CYLN1;restin;cytoplasmic linker protein 1;cyt
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLIP1-3582M | Recombinant Mouse CLIP1 Protein | Mammalian Cells | Mouse | His |
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| CLIP1-6502C | Recombinant Chicken CLIP1 | Mammalian Cells | Chicken | His |
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| CLIP1-1756M | Recombinant Mouse CLIP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CLIP1-1756M-B | Recombinant Mouse CLIP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CLIP1-2717H | Recombinant Human CLIP1 protein(371-940 aa), C-His-tagged | E.coli | Human | His | 371-940 aa |
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Involved Pathway
CLIP1 involved in several pathways and played different roles in them. We selected most pathways CLIP1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| M Phase | NIPBLB,CENPK,PDS5A,NDEL1A,GORASP2,PDS5B,PANE1,SMC2,MIS12,CENPQ |
| RHO GTPases Activate Formins | DSN1,MKL1B,ZWILCH,DIAPH1,RHOAE,NDEL1B,SPC25,ZWINT,AHCTF1,FMNL2 |
| Cell Cycle, Mitotic | CENPN,CENPE,CEP63,PCM1,TSGA14,MLF1IP,HIST4H4,CDT1,CEP152,SPC24 |
| Cell cycle | CSNK2B,TFDP1,CDK2,MAPRE1,NEDD1,BUB3,NCAPH,B9D2,ORC6,E2F5 |
| Mitotic Metaphase and Anaphase | CENPP,NUDC,SKA2,SGOL2,PDS5A,CENPC1,CDCA5,ITGB3BP,SKA1,ZW10 |
| Mitotic Anaphase | SKA2,CENPC1,NSL1,LEMD3,TMPO,B9D2,NDEL1A,ERCC6L,NDC80,CENPH |
| RHO GTPase Effectors | WIPF2,KTN1,ABI2,NOXO1A,NCKAP1,PMF1,ABI1,LIN7B,RHOAE,NF2A |
| Mitotic Prometaphase | CCDC99,RCC2,CDCA5,NUF2,SKA2,CENPN,SPC25,SPDL1,NDEL1B,NCAPH |
Protein Function
CLIP1 has several biochemical functions, for example, metal ion binding,microtubule binding,microtubule plus-end binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIP1 itself. We selected most functions CLIP1 had, and list some proteins which have the same functions with CLIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule plus-end binding | APC,CLIP2,CLASP1,MAPRE1,CLASP1A,DST,KIF18A,STIM1,KIF2C |
| protein binding | INVS,COQ7,XBP1,SMCP,LANCL2,TFAP2C,ALX1,ZNF180,ADD1,BAIAP2 |
| tubulin binding | BRCA1,BIRC5,TPR,STMN1B,RABGAP1,ATF5,DAG1,AGBL5,NCALD,TTLL4 |
| nucleic acid binding | FEZF1,RNASEH1,ZFP39,ZFP653,ZBTB2A,N6AMT1,GLIS2B,HNRNPABB,CHD6,ZFP426 |
| zinc ion binding | PIAS4B,ZMYM5,PHEX,ANAPC11,POLE,L3MBTL1,UQCRC2B,PIAS4,GLI2,GATAD2A |
| microtubule binding | KIFC1,MAP1LC3B,PRC1A,JAKMIP1,TRPV4,KIF18B,LRPPRC,NUMA1,KIF7,PRNP |
| metal ion binding | ZFP74,HIC1L,FBXO30B,DMRTA1,IDO1,SCAPER,BTY,ZNF433,ZNF26,LNPA |
Interacting Protein
CLIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIP1.
Diaph1;Clasp1;Ywhae;Ywhab
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References
- Calligaris, D; Manatschal, C; et al. Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes. JOURNAL OF PROTEOMICS 75:3605-3616(2012).
