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CLN8

Official Full Name

ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Overview

This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.
Synonyms

CLN8; ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); C8orf61, chromosome 8 open reading frame 61 , EPMR; protein CLN8; FLJ39417; EPMR; C8orf61;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Canis lupus familiaris (Dog) (Canis familiaris)
Chicken
Homo sapiens (Human)
Human
Mus musculus (Mouse)
Rat
Rattus norvegicus (Rat)
Rhesus Macaque
Zebrafish

Source

E.coli
E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CLN8-38H	Recombinant Human CLN8 protein, His-tagged	E.coli	His	301aa(including fusion tag)	Inquiry
Rat	CLN8-1457R	Recombinant Rat CLN8 Protein	Mammalian Cell	His		Inquiry
Rat	CLN8-1115R	Recombinant Rat CLN8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CLN8-1115R-B	Recombinant Rat CLN8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Canis lupus familiaris (Dog) (Canis familiaris)	RFL6057CF	Recombinant Full Length Dog Protein Cln8(Cln8) Protein, His-Tagged	E.coli expression system	His	Full Length (1-288)	Inquiry
Homo sapiens (Human)	RFL29901HF	Recombinant Full Length Human Protein Cln8(Cln8) Protein, His-Tagged	E.coli expression system	His	Full Length (1-286)	Inquiry
Mus musculus (Mouse)	RFL36977MF	Recombinant Full Length Mouse Protein Cln8(Cln8) Protein, His-Tagged	E.coli expression system	His	Full Length (1-288)	Inquiry
Rattus norvegicus (Rat)	RFL27236RF	Recombinant Full Length Rat Protein Cln8(Cln8) Protein, His-Tagged	E.coli expression system	His	Full Length (1-288)	Inquiry
Rhesus Macaque	CLN8-914R	Recombinant Rhesus monkey CLN8 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CLN8-739R-B	Recombinant Rhesus Macaque CLN8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	CLN8-739R	Recombinant Rhesus Macaque CLN8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	CLN8-6451Z	Recombinant Zebrafish CLN8	Mammalian Cell	His		Inquiry
Chicken	CLN8-2762C	Recombinant Chicken CLN8	Mammalian Cell	His		Inquiry

CLN8 involved in several pathways and played different roles in them. We selected most pathways CLN8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLN8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CLN8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CLN8 itself. We selected most functions CLN8 had, and list some proteins which have the same functions with CLN8. You can find most of the proteins on our site.

Function	Related Protein

CLN8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLN8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLN8.