PTGS2
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Official Full Name
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
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Overview
Cytochrome c oxidase subunit II, also known as COX2, is a human protein and gene. that belongs to cytochrome c oxidase subunit II protein family. It is sometimes confused with the cyclooxygenase enzyme COX-2. -
Synonyms
Ptgs2; prostaglandin-endoperoxide synthase 2; COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin G/H synthase, Tis10;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Chicken
- Human
- Mouse
- Rat
- Sheep
- E.coli
- HEK293
- Insect cell
- Insect Cell
- Insect cells
- Insect Cells
- Mammalian Cell
- Sf21 Insect Cell
- Sheep placenta
- C
- His
- Flag|His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PTGS2 Related Articles
- PTGS2 Related Research Area
PTGS2 involved in several pathways and played different roles in them. We selected most pathways PTGS2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP2C70;MAPKAPK2B;CYP4A12A;FAM213B;LTA4H;CYP4B1;PTGS2A;CYP2C50;ALOX12 |
| Metabolic pathways | AMY2A4;GALNT9;ATP6V0B;CYP51;GPT;FTCD;PDHA1;ALPI.2;DBH |
| NF-kappa B signaling pathway | BCL2A1;TRAF1;DDX58;LTA;ERC1;MAP3K7;NFKB1;TRADD;TRAF5 |
| VEGF signaling pathway | NRAS;RAC3B;PIK3CG;PRKCBA;AKT3A;PPP3CB;AKT1;RAF1A;PRKCBB |
| TNF signaling pathway | Casp3;TRAF1;BAG4;BCL3;MAP2K4;MAP2K3;ITCH;IL6;MAGI2 |
| Retrograde endocannabinoid signaling | PTGS2;GNG10;GNGT1;PLCB1;GABRG1;GABRA6;GABRR1;GABRQ;GNAQ |
| Serotonergic synapse | GABRB1;GNG10;GABRB3;HTR3E;GNAQ;PLCB1;PLA2G4A;HTR3C;MAOA |
| Ovarian steroidogenesis | HSD3B2;CYP2J5;PLA2G4F;BMP15;PRKACG;CYP2J6;HSD3B1;Adcy4;LHCGR |
| Oxytocin signaling pathway | PPP1R12C;RYR2;PIK3R2;CACNG1;PLA2G4A;RYR3;PIK3R3;MYLK;OXT |
| Regulation of lipolysis in adipocytes | PDE3B;LOC100328615;PIK3CG;GNAI3;INS;Adcy4;AKT2;PIK3CB;PTGER3 |
| Leishmaniasis | MAPK13;IRAK4;ITGB2L;H2-AB1;RELA;NFKB1;H2-AA;IFNGR2;HLA-DMA |
| Pathways in cancer | FGFR2;BIRC5;TGFA;RALB;PLCG2;IKBKB;FH1;FGF10;MITF |
| Chemical carcinogenesis | CYP3A7;CYP3A41B;ADH2-1;UGT2B7;GSTM3;CYP3A41A;UGT1A7;CYP2C50;GSTT2 |
| MicroRNAs in cancer | Casp3;ERBB3;FGFR3;IKBKB;TP63;TGFB2;THBS1;VIM;NOTCH4 |
| Small cell lung cancer | PIAS2;NFKB1;PIK3CB;CYCS;LAMB3;ITGA6;LAMA3;PTEN;RXRB |
PTGS2 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS2 itself. We selected most functions PTGS2 had, and list some proteins which have the same functions with PTGS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dioxygenase activity | P4HA1B;ALKBH7;BCO1;PHYHD1;JMJD5;TDO2B;ALKBH6;HPDB;KDM4D |
| heme binding | CYP2K22;HRG-1;CYP46A1.1;CYP2AA1;CYP2A6;CYP2A7;PTGES2;CYP2AA3;CYP2J2 |
| lipid binding | DBI;FABP7A;RBP2A;DOK7;ANXA6;APOA1A;ACBD5A;STARD8;SH3GL3 |
| metal ion binding | ANTXR2A;ARHGAP29B;CYP8B3;RXRAA;RUFY2;SMAD6;KCND3;CARNS1;DHX57 |
| peroxidase activity | GPX1A;PTGS2;CYGB;GPX1B;PXDN;GPX5;MGST3;PRDX5;GPX6 |
| prostaglandin-endoperoxide synthase activity | PTGS2A;PTGS2B;PTGS1;PTGS2 |
PTGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS2.
arachidonic acid; ns398; q9wmx2-pro_0000037550; LRRK2
- Q&As
- Reviews
Q&As (6)
Ask a questionPTGS2 is involved in the inflammatory cascade and increases the response of inflammatory factors such as TNF-α, IL-1β, and IL-6.
PTGS2 has been closely associated with studies of glandular cystitis and cerebral small vessel disease.
BCL6 acts at the promoter of PTGS2.
PTGS2 is a key gene for prostaglandin synthesis in pathological conditions.
PTGS2 is localized in the nuclear membrane.
PTGS2 expression showed high levels in glandular cystitis and its involvement in the development of glandular cystitis.
Customer Reviews (3)
Write a reviewThe staff was very nice, communicated with me positively and solved a lot of technical problems.
The technician gave me a thorough introduction to the PTGS2 protein so that I could understand its biochemical properties.
High quality product at a good price, a satisfactory shopping experience.
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