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CPEB2

Official Full Name

cytoplasmic polyadenylation element binding protein 2
Overview

The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms

CPEB2; cytoplasmic polyadenylation element binding protein 2; cytoplasmic polyadenylation element-binding protein 2; CPE binding protein 2; CPE BP2; CPEBP2; hCPEB2; OTTHUMP00000115833; OTTHUMP00000115834; OTTHUMP00000217612; OTTHUMP00000217613; OTTHUMP00000217614; CPE-binding protein 2; CPEB-2; CPE-BP2; hCPEB-2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CPEB2-11517H	Recombinant Human CPEB2, His-tagged	E.coli	His	1-164a.a.	$319 / 25ug

Involved Pathway
Protein Function
Interacting Protein

CPEB2 involved in several pathways and played different roles in them. We selected most pathways CPEB2 participated on our site, such as Dorso-ventral axis formation, Oocyte meiosis, Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPEB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Dorso-ventral axis formation	SOS1;CPEB3;ETS2;GRB2A;ETV6;SPIRE2;CPEB4;CPEB1B;CPEB1
Oocyte meiosis	PRKACBA;AURKA;ADCY1A;CDC23;FBXW11B;CDC16;YWHAZ;PPP1CA;CPEB1
Progesterone-mediated oocyte maturation	AKT2;IGF1RB;CCNA1;CDC25A;CDC25C;RPS6KA3A;PRKACAA;PRKACBB;HSP90AB1

CPEB2 has several biochemical functions, for example, GTPase inhibitor activity, mRNA 3-UTR AU-rich region binding, mRNA 3-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPEB2 itself. We selected most functions CPEB2 had, and list some proteins which have the same functions with CPEB2. You can find most of the proteins on our site.

Function	Related Protein
GTPase inhibitor activity	RHOH;GPS2;ARL2;RTKN;IPO5;TNK2;CDC42SE1;CPEB2;PDE6D
mRNA 3-UTR AU-rich region binding	ELAVL1;CPSF1;CPEB2;CPEB1B;ZFP36;CPEB1;CPEB3
mRNA 3-UTR binding	CPEB1A;TARDBP;CARHSP1;ZNF385A;IGF2BP3;RBMS3;RNF20;CPEB4;CPEB2
nucleotide binding	TDRD9;DDX19;MAP2K4B;SEPT9B;SFRS3A;SBK1;GNAIA;DAZAP1;EIF4A1B
poly(A) RNA binding	RPS27A;PPIB;KIF1C;HNRPDL;RNPS1;MACF1;CIRBP;HNRNPAB;DCAF13
poly-pyrimidine tract binding	CPEB2;PTBP1;U2AF2
ribosomal large subunit binding	MRRF;NMD3;EIF6;OLA1;NPM1;MALSU1;CPEB2;RBM3
ribosomal small subunit binding	NME1;PTCD3;CPEB2;DHX29;PIM1;NPM1;ERAL1;DDX3X;MTIF3
ribosome binding	CPEB1A;ERI1;YTHDF1;HSPA5;EFTUD1;EIF5A;BAG6;RPN2;CPEB2
translation factor activity, RNA binding	MTIF3;SOX11;EIF2S2;EIF5;EEF2K;GTF2H2;ABCF1;EIF4H;EIF2S3
translation repressor activity, nucleic acid binding	CPEB4;CPEB1A;CPEB1B;CELF4;CPEB2;PURA;PAIP2B;CPEB3;PPP1R2P9

CPEB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPEB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPEB2.