creb1

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creb1

Official Full Name cAMP responsive element binding protein 1
Background CREB (cAMP response element-binding) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
Synonyms CREB1; cAMP responsive element binding protein 1provided; CREB; MGC9284; cyclic AMP-responsive element-binding protein 1; CREB-1; OTTHUMP00000163864; OTTHUMP00000163865; OTTHUMP00000206660; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CREB1-183H Recombinant Human CREB1, His-tagged E. coli His
    Human CREB1-1107H Recombinant Human CREB1 Protein Mammalian cell His
    Human CREB1-162H Recombinant Human CREB1, GST-tagged E.coli GST
    Human CREB1-182H Recombinant Human CREB1 Protein, His-tagged E.coli His
    Human CREB1-1839H Recombinant Human CREB1 Protein, GST-tagged Wheat Germ GST
    Human CREB1-26H Recombinant Human CREB1 E.coli N/A
    Human CREB1-6915H Recombinant Human CREB1, His & MBP tagged E.coli His/MBP
    Human CREB1-7289HCL Recombinant Human CREB1 293 Cell Lysate HEK293 N/A
    Rat Creb1-1443R Recombinant Rat cAMP Responsive Element Binding Protein 1, GST-tagged E.coli GST
    Rat CREB1-1588R Recombinant Rat CREB1 Protein Mammalian Cell His
    Rhesus Macaque CREB1-1019R Recombinant Rhesus monkey CREB1 Protein, His-tagged Mammalian Cell His
    Chicken CREB1-6020C Recombinant Chicken CREB1 Mammalian Cell His

    creb1 involved in several pathways and played different roles in them. We selected most pathways creb1 participated on our site, such as AKT phosphorylates targets in the nucleus, AMPK signaling pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with creb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AKT phosphorylates targets in the nucleus AKT3; CREB1B; CREB1
    AMPK signaling pathway FBP1; PPP2R5E; MTOR; PPP2CB; G6PC2; Scd2; FASN; PPP2R5A; INS1; PRKAG2
    ATF-2 transcription factor network MAPK14; DUSP10; KAT5; ATF2; CBFB; JUND; CSRP2; CREB1; GADD45A; POU2F1
    ATM Signaling Pathway GADD45A; CREB1
    Activated TLR4 signalling DUSP3B; MAP3K8; S100B; DUSP7; MAPK14; AGER; ATF2; SIGIRR; CHUK; APPB
    Activation of NMDA receptor upon glutamate binding and postsynaptic events ADCY1; AKAP9; NEFLB; CREB1; PDPK1A; CREB1B; ADCY8; SLC14A2; CAMKK1B; DLG4
    Adaptive Immune System ITGB1B.1; PJA1; CTLA4; CD300E; RNF19B; RNF4; CD200R1; KIF11; TRIM50; MGC174155
    Adipogenesis CEBPD; DDIT3; CISD1; KLF6A; NCOA2; MBNL1; BMP1; KLF7; GTF3AA; NR2F1

    creb1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by creb1 itself. We selected most functions creb1 had, and list some proteins which have the same functions with creb1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II activating transcription factor binding CTNNB1; BHLHE40; JUN; ISL1; ZFPM1; BEX1; TBX20; LMO2; CREBBP; TBX6
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MYPOP; PITX3; POU3F2; JDP2; PRDM5; MTF1; GLI3; FIGLA; ASCL2; NKX2-5
    RNA polymerase II distal enhancer sequence-specific DNA binding SFPI1; GZF1; H2AFZ; REL; CDX1; ARID3B; NR1H4; RUVBL2; GATA2; SFPQ
    cAMP response element binding E4F1; JUN; CREB3L1; HMGA2; CREB3L3; ATF6; ATF6B; CREB3L4; CREB3; CREB3L2
    enzyme binding LDB1; GSTM3; PLSCR1; ATG3; LAMP1; TP53; NPM2; TSPAN14; CA; POLB
    histone acetyltransferase binding TAF7L; FOXP3; KAT2B; HIF1A; ETS1; TRP53; CEBPB; PCNA; EPAS1; GLI3
    protein binding TIPRL; ECT2; ATCAY; DYNC2LI1; RFX3; LRPAP1; DLAT; SEPT2; SAP30L; DHH
    transcription cofactor activity BTG1; ZMYND11; ZNF671; NFKBIZ; MED4; ZNF710; PHF21B; IRF3; MAP3K7; SND1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding NKX2-1; POU4F1; GATA5; GATA4; LEF1; SPI1; HIF1A; FOXF2A; SOX7; BHLHE40
    transcription factor activity, sequence-specific DNA binding ZNF549; RFXANK; DLX4; RB1; NR2F6; LMO4; HELT; VAX2; RUNX1T1; FOXP2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DLX3; E2F4; TFAP4; NEUROG3; FOSB; FOS; MZF1; NR3C1; EPAS1; JUNB
    transcriptional activator activity, RNA polymerase II transcription factor binding PITX1; NKX2-5; LMO2; KLF4; NFE2L1; PPARA; NKX2; KLF14; NR1H4; MED12

    creb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with creb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of creb1.

    TSSK4; MEIS1; CREBBP; PASK; p03259-2

    Matsumura, H; Nakayama, Y; et al. Effects of interleukin-11 on the expression of human bone sialoprotein gene. JOURNAL OF BONE AND MINERAL METABOLISM 33:142-153(2015).
    Matsumura, H; Ogata, Y; et al. Melatonin regulates human bone sialoprotein gene transcription. JOURNAL OF ORAL SCIENCE 56:67-76(2014).

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