CRYAB

  • Official Full Name

    crystallin, alpha B

  • Overview

    Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the;major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens;central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout;life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma;families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided;into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting;peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B,;for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat;shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature;proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.;Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40;subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha;crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene;products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed;widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a;missense mutation cosegregated in a family with a desmin-related myopathy.
  • Synonyms

    CRYAB; crystallin, alpha B; CRYA2; alpha-crystallin B chain; HSPB5; heat shock protein beta-5; rosenthal fiber component; heat-shock 20 kD like-protein; renal carcinoma antigen NY-REN-27; CTPP2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRYAB-9158H Recombinant Human CRYAB protein E.coli N/A
Human CRYAB-27293TH Recombinant Human CRYAB E.coli N/A
Human CRYAB-1926H Recombinant Human CRYAB Protein, GST-tagged Wheat Germ GST
Human CRYAB-31725TH Recombinant Human CRYAB, His-tagged E.coli His 175 amino acids
Human CRYAB-185H Recombinant Human CRYAB Mammalian Cell His
Human CRYAB-310H Recombinant Human Crystallin Alpha B E.coli N/A
Human CRYAB-7266HCL Recombinant Human CRYAB 293 Cell Lysate HEK293 N/A
Human CRYAB-2128HF Recombinant Full Length Human CRYAB Protein, GST-tagged In Vitro Cell Free System GST 175 amino acids
Human CRYAB-3827H Recombinant Human CRYAB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CRYAB-01H Recombinant Human CRYAB Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CRYAB-1820H Recombinant Human CRYAB Protein (Met1-Lys175), C-His tagged E.coli C-His Met1-Lys175
Human CRYAB-2524H Recombinant Human CRYAB protein(21-170 aa), C-His-tagged E.coli C-His 21-170 aa
Human CRYAB-2734H Recombinant Human CRYAB protein, His-SUMO-tagged E.coli His-SUMO 1-175aa
Human CRYAB-668H Recombinant Human CRYAB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRYAB-1060HFL Recombinant Full Length Human CRYAB Protein, C-Flag-tagged Mammalian cells Flag
Human CRYAB-668H-B Recombinant Human CRYAB Protein Pre-coupled Magnetic Beads HEK293
Human CRYAB-1822H Recombinant Human CRYAB Protein (Met1-Lys175), N-His tagged E.coli N-His Met1-Lys175
Mouse Cryab-330M Recombinant Mouse Crystallin, Alpha B E.coli N/A
Mouse CRYAB-3934M Recombinant Mouse CRYAB Protein Mammalian Cell His
Mouse Cryab-2326M Recombinant Mouse Cryab Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CRYAB-1995M Recombinant Mouse CRYAB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cryab-002M Recombinant Mouse Cryab Protein E.coli 175
Mouse CRYAB-1995M-B Recombinant Mouse CRYAB Protein Pre-coupled Magnetic Beads HEK293
Rat CRYAB-1610R Recombinant Rat CRYAB Protein Mammalian Cell His
Rat CRYAB-1268R-B Recombinant Rat CRYAB Protein Pre-coupled Magnetic Beads HEK293
Rat CRYAB-1268R Recombinant Rat CRYAB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CRYAB-422C Recombinant Cynomolgus CRYAB Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CRYAB-170C-B Recombinant Cynomolgus Monkey CRYAB Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CRYAB-170C Recombinant Cynomolgus Monkey CRYAB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CRYAB-1037R Recombinant Rhesus monkey CRYAB Protein, His-tagged Mammalian Cell His
Rhesus Macaque CRYAB-862R-B Recombinant Rhesus Macaque CRYAB Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CRYAB-862R Recombinant Rhesus Macaque CRYAB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CRYAB-6731C Recombinant Chicken CRYAB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CRYAB involved in several pathways and played different roles in them. We selected most pathways CRYAB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumSVIP;DNAJB11;MARCH6;UBE2D2;PRKCSH;RBX1;DAD1;SAR1AB;DNAJB2

CRYAB has several biochemical functions, for example, identical protein binding, metal ion binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYAB itself. We selected most functions CRYAB had, and list some proteins which have the same functions with CRYAB. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingCRYBB2;CCL3;BCAT1;DYRK1A;DYNLT1;TRIP13;MYOM1;TMEM173;LCK
metal ion bindingSMAD1;VAV2;RNF144AB;ZNF577;SUZ12A;GM5077;ZNF567;FYCO1;NRXN3A
microtubule bindingARHGEF2;MAP4;EML1;LRPPRC;GAS2L3;KLC3;CKAP5;VAPB;NDEL1A
protein bindingF10;ZBTB16;ANXA11;GNG4;NR2E3;SIRPB1;SOCS1;FANCM;SPACA3
protein homodimerization activityALX1;XCL1;DMRTC2;ZNF174;SYT6;ERBB4;JUP;TPR;RBM44
structural constituent of eye lensBFSP1;CPOX;LIM2.2;LIM2;CRYGN1;CRYBA2;CRYBB3;VIM;CRYGN2
unfolded protein bindingCRYAB;CCT8;HSPA1L;CALR3B;H2-KE2;SSUH2RS1;DNAJA3A;GRXCR2;DNAJA3B

CRYAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYAB here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYAB.

CRYAA; HSPB1; CRYGC

Research Area

Related articles

Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
Campbell-Lloyd, AJM; Mundy, J; et al. Is Alpha-B Crystallin an Independent Marker for Prognosis in Lung Cancer?. HEART LUNG AND CIRCULATION 22:759-766(2013).
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