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Official Full Name cytochrome P450, family 11, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
Synonyms CYP11A1; cytochrome P450, family 11, subfamily A, polypeptide 1; CYP11A; CYPXIA1; P450SCC; cholesterol side-chain cleavage enzyme, mitochondrial; steroid 20-22-lyase; cytochrome P450 11A1; cytochrome P450(scc); cytochrome P450C11A1; cholesterol 20-22 desmolase; cholesterol monooxygenase (side-chain cleaving); cytochrome P450, subfamily XIA (cholesterol side chain cleavage);
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP11A1-11761H Recombinant Human CYP11A1, His-tagged E.coli His
    Human CYP11A1-4529H Recombinant Human CYP11A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP11A1-7131H Recombinant Human CYP11A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP11A1-7131HCL Recombinant Human CYP11A1 293 Cell Lysate HEK293 N/A
    Human CYP11A1-7132H Recombinant Human CYP11A1 protein, GST-tagged Wheat Germ GST
    Human CYP11A1-8077H Recombinant Human CYP11A1 protein, His & T7-tagged E.coli His/T7
    Mouse Cyp11a1-2409M Recombinant Mouse Cyp11a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse CYP11A1-4144M Recombinant Mouse CYP11A1 Protein Mammalian Cell His
    Mouse Cyp11a1-8078M Recombinant Mouse Cyp11a1 protein, His-tagged E.coli His
    Rat CYP11A1-1713R Recombinant Rat CYP11A1 Protein Mammalian Cell His
    Chicken CYP11A1-1152C Recombinant Chicken CYP11A1 Mammalian Cell His
    Zebrafish CYP11A1-9420Z Recombinant Zebrafish CYP11A1 Mammalian Cell His
    Cattle CYP11A1-8076C Recombinant Cattle CYP11A1 protein, His & T7-tagged E.coli His/T7
    Pig CYP11A1-8079P Recombinant Pig CYP11A1 protein, His & T7-tagged E.coli His/T7

    cyp11a1 involved in several pathways and played different roles in them. We selected most pathways cyp11a1 participated on our site, such as Aldosterone synthesis and secretion, Biological oxidations, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp11a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone synthesis and secretion PRKD2; CREB5; NR4A1; PLCB3; CALML3; GNA11; AKR1C1; NPR1; GNAQ; CALML5
    Biological oxidations CYP2K18; GGT6; MTRR; CYP2E1; CYP3A5; SLC35D1A; CYP2K22; CYP1A2; BPNT1; SULT1ST6
    Corticotropin-releasing hormone CRH; KRT14; JUND; CYP11A1; CRHR1; IVL; CYP21A2; TBX19; TFAP2A; CYP11B1
    Cytochrome P450 - arranged by substrate type CYP17A1; CYP2V1; CYP2U1; CYP4B1; CYP19A1; FDX1L; CYP2N13; CYP26A1; CYP21A2; CYP1B1
    Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) FDXR; FDX1; CYP11A1; FDX1L
    Diseases of metabolism AMN; MMADHC; GYG2; GYG1; EPM2A; CYP11A1; SFTPB; FDX1; CCDC59; FDXR
    Endogenous sterols CYP1B1; CYP11A1; CYP21A2; CYP11B1; CYP51A1; CYP8B2; CYP11B2; CYP17A1; CYP7A1; CYP27A1

    cyp11a1 has several biochemical functions, for example, cholesterol binding, cholesterol monooxygenase (side-chain-cleaving) activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp11a1 itself. We selected most functions cyp11a1 had, and list some proteins which have the same functions with cyp11a1. You can find most of the proteins on our site.

    Function Related Protein
    cholesterol binding OSBPL8; APOA4; APOA4B.2; APOEA; CYP11A1; APOA2; APOF; APOA1; OSBP2; ANXA6
    cholesterol monooxygenase (side-chain-cleaving) activity CYP11A1
    heme binding CYP2C19; CYP4B1; CYP3C4; CYP2P8; CYP4A14; NOS1; CYP3A5; BACH1; IDO2; TPO
    iron ion binding CYP2P8; CYP2C50; PLOD2; SLC11A2; AOX3; ALOX12E; CYP24A1; CYP2K6; PAH; HBBE2
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen CYP11B1; MTRR; CYP4F2; MICAL2; CYP4F18; NDOR1; CYP11C1; CYP11B2; MICAL1; CYP4F11

    cyp11a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp11a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp11a1.

    SMAD9; SMAD3; SMAD2; A2M

    Guo, JJ; Li, XW; et al. The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. TOXICOLOGY 306:9-15(2013).
    Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).

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