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CYP26A1

  • Official Full Name

    cytochrome P450, family 26, subfamily A, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.
  • Synonyms

    CYP26A1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450 26A1; CP26; CYP26; P450RAI; P450RAI1; hP450RAI; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactiva;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP26A1-8072H Recombinant Human CYP26A1 protein, His & T7-tagged E.coli His/T7 Arg73~Ile255 (Accession # O43174)
Human CYP26A1-7121HCL Recombinant Human CYP26A1 293 Cell Lysate HEK293 N/A
Human CYP26A1-5366H Recombinant Human CYP26A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CYP26A1-1877HFL Recombinant Full Length Human CYP26A1 Protein, C-Flag-tagged Mammalian cells Flag
Human CYP26A1-700H Recombinant Human CYP26A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYP26A1-700H-B Recombinant Human CYP26A1 Protein Pre-coupled Magnetic Beads HEK293
Human CYP26A1-1915H Recombinant Human CYP26A1 Protein (Arg73-Ile255), N-His tagged E.coli N-His Arg73-Ile255
Mouse Cyp26a1-8073M Recombinant Mouse Cyp26a1 protein, His & T7-tagged E.coli His/T7 Asn250~Gly495 (Accession # O55127)
Mouse CYP26A1-4154M Recombinant Mouse CYP26A1 Protein Mammalian Cell His
Mouse Cyp26a1-2415M Recombinant Mouse Cyp26a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CYP26A1-2130M Recombinant Mouse CYP26A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CYP26A1-2130M-B Recombinant Mouse CYP26A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP26A1-1140R Recombinant Rhesus monkey CYP26A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP26A1-965R-B Recombinant Rhesus Macaque CYP26A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP26A1-965R Recombinant Rhesus Macaque CYP26A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CYP26A1-8761Z Recombinant Zebrafish CYP26A1 Mammalian Cell His
Chicken CYP26A1-1069C Recombinant Chicken CYP26A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP26A1 Related Articles

CYP26A1 involved in several pathways and played different roles in them. We selected most pathways CYP26A1 participated on our site, such as Adipogenesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP26A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisCNTFR;DVL1;NRIP1;FRZB;KLF6;PIANP;BMP3;RETN;GATA2
Biological oxidationsPOMCB;TPMT.2;CYP8B2;CYP11A1;UGT1B1;SULT1ST6;CYP2K19;GLYATL1;CYP2E1
Cytochrome P450 - arranged by substrate typeCYP2V1;CYP2Y3;CYP3A7;FDX1L;CYP4F12;CYP2S1;CYP11B1;CYP2K16;CYP2AD6
Metabolic pathwaysMAPK1IP1L;GCDH;AK9;DGKE;LDHA;CSAD;SPHK2;ADOB;BCKDHB
MetabolismSLC5A9;SCP2B;SLC6A8;ARL2BP;MAPK1IP1L;SLC25A32;SLC2A3;ARSJ;CYP2D6
Nuclear receptors in lipid metabolism and toxicityCYP24A1;ABCC2;CYP27B1;NR1I3;VDRB;RARGB;NR1I2;RARG;RARGA
Phase 1 - Functionalization of compoundsCYP2K6;CYP2K19;CYP2F1;CYP26A1;CYP3A7-CYP3AP1;CYP4F12;CYP2C18;CYP27B1;ADH8A
RA biosynthesis pathwayCRABP1;ADH8A;RDH14B;AKR1C21;DHRS3;SDR16C5;ADH8B;RDH14;ALDH8A1

CYP26A1 has several biochemical functions, for example, heme binding, iron ion binding, oxygen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP26A1 itself. We selected most functions CYP26A1 had, and list some proteins which have the same functions with CYP26A1. You can find most of the proteins on our site.

Function Related Protein
heme bindingCYP11B2;HBAA;CYP3C1L2;CYP2AA12;SDHDA;NGB;CYP2AD2;CYP2D9;CYP4F22
iron ion bindingCYP3C1;PLOD1A;BA1;CYP46A1.2;TPH1A;HBG1;LEPREL2;FA2H;CYP27C1
oxygen bindingHBBE1.1;HBM;CYP2W1;CYP26A1;CYP2C55;CYGB;CYP2D10;CYP2Y3;CYP2D6
retinoic acid 4-hydroxylase activityCYP26A1;CYP26B1
retinoic acid bindingCRABP1B;LCN12;CRABP2A;UGT1A1;LRAT;PTGDSB;CRABP1A;UGT1A3;CRABP1

CYP26A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP26A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP26A1.

Brown, GT; Cash, BG; et al. The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer. PLOS ONE 9:-(2014).
Liu, HY; Chao, HH; et al. Regulation of cyp26a1 on Th17 cells in mouse peri-implantation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:455-467(2014).
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