CYP2A6
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Official Full Name
cytochrome P450, family 2, subfamily A, polypeptide 6 -
Overview
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. -
Synonyms
CYP2A6;cytochrome P450, family 2, subfamily A, polypeptide 6;CYP2A3, cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 6;cytochrome P450 2A6;CPA6;CYP2A;cytochrome P450(I);cytochrome P450 IIA3;coumarin 7-hydroxylase;xenobiotic
Recombinant Proteins
- Human
- Insect Cells
- HEK293
- Wheat Germ
- Human Cells
- E.coli
- Mammalian Cells
- Non
- DDK
- Myc
- GST
- Flag
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP2A6-125H | Recombinant Human CYP2A6 | Insect Cells | Human | Non |
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| CYP2A6-126H | Recombinant Human CYP2A6, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| CYP2A6-2258H | Recombinant Human CYP2A6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP2A6-7117HCL | Recombinant Human CYP2A6 293 Cell Lysate | HEK293 | Human | Non |
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| CYP2A6-01H | Recombinant Human CYP2A6 Protein, Flag-tagged | Human Cells | Human | Flag |
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| CYP2A6-12H | Active Recombinant Human CYP2A6 Protein | E.coli | Human |
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| CYP2A6-2732H | Recombinant Human CYP2A6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| CYP2A6-2792H | Recombinant Human CYP2A6 protein, His&Myc-tagged | E.coli | Human | His&Myc | 29-494aa |
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| CYP2A6-71H | Recombinant Human CYP2A6 Protein | E.coli | Human |
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| CYP2A6-8499HFL | Recombinant Full Length Human CYP2A6, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| Kit-0923 | CYP2A6 Blue Screening Kit | Non |
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Involved Pathway
CYP2A6 involved in several pathways and played different roles in them. We selected most pathways CYP2A6 participated on our site, such as Biological oxidations,CYP2E1 reactions,Caffeine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | UGT5G1,TYMP,UGT1A6B,UCK2,UMPS,UCKL1,DPYD,GMPS,UGT2A1,UPP2 |
| Chemical carcinogenesis | ARNT,PTGS2,UGT1A1,CYP2C55,CYP2C18,UGT1A7C,GSTT2,UGT2A3,CYP3A5,GSTA1 |
| Cytochrome P450 - arranged by substrate type | CYP2K18,CYP11B1,CYP2C19,CYP4F22,FAM84B,CYP2K19,CYP27B1,CYP3A5,CYP2V1,CYP3A7 |
| CYP2E1 reactions | CYP2C8,CYP2C19,CYP2Y3,CYP2A13,CYP2E1,CYP2B6,CYP2D6,CYP2A7,CYP2C9,CYP2S1 |
| Biological oxidations | FDX1,NAT2,POMCB,ADH8B,UGT1B1,SULT2ST2,CYP2K18,CYP2V1,CYP3C4,CYP2K19 |
| Fatty Acid Omega Oxidation | ADH4,ADH1C,CYP4A11,CYP2E1,ADH1B,CYP2D6,CYP1A1,ADH1A,ADH6,ADH7 |
| Caffeine metabolism | CYP1A2,XDH,PNAT10,NAT,UOX,PNAT3,NAT2,NAT1,Nat3 |
| Drug metabolism - cytochrome P450 | CYP2C8,ADH1A,CYP2E1,ADH4,ADH2-1,CYP2C9,CYP2D6,ADH1C,ADH2-2,ADH5 |
Protein Function
CYP2A6 has several biochemical functions, for example, arachidonic acid epoxygenase activity,coumarin 7-hydroxylase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A6 itself. We selected most functions CYP2A6 had, and list some proteins which have the same functions with CYP2A6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coumarin 7-hydroxylase activity | CYP2A4 |
| arachidonic acid epoxygenase activity | CYP2C19,CYP2D9,CYP2C39,CYP2B6,CYP2AD3,CYP2D26,CYP2C37,CYP2S1,CYP2C38,CYP2N13 |
| iron ion binding | JMJD6,CYP4A10,HBAA1,CYP2Y3,CYP46A1.2,HIF1AN,HBB-Y,CYP1B1,OGFOD2,LTF |
| steroid hydroxylase activity | BRSK2,CYP2A7,CYP2A13,CYP2V1,CYP2AA4,CYP46A1,CYP2J5,CYP2D10,CYP2C50,CYP2AA3 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2P10,CYP2AA6,CYP2C50,CYP2W1,CYP1A,CYP2K19,CYP2A12,CYP2N13,CYP2AA7,CYP2R1 |
| heme binding | MFSD7C,PTGS2,CYP17A2,CYP2C37,CYP4T8,HBBE3,TDO2A,CYP2K16,HBM,CYP2F1 |
| enzyme binding | SNX12,AXIN2,JUND,HSPA1A,YWHAH,HIST1H2AD,YWHAE,ZFHX3,NKX2-1,CPSF1 |
| oxygen binding | HBG1,CYP2P9,CYP2J6,CYP1A1,CYP2AD3,CYP2N13,CYP4B1,HBD,CYP2D6,CYP2P7 |
Interacting Protein
CYP2A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A6.
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References
- Sliwinska-Mosson, M; Zielen, I; et al. NEW TRENDS IN THE TREATMENT OF NICOTINE ADDICTION. ACTA POLONIAE PHARMACEUTICA 71:525-530(2014).
- Pearce, RE; Cohen-Wolkowiez, M; et al. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low K-m) Catalyst. DRUG METABOLISM AND DISPOSITION 41:1686-1694(2013).
