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Official Full Name cytochrome P450, family 2, subfamily C, polypeptide 18
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms CYP2C18; cytochrome P450, family 2, subfamily C, polypeptide 18; CYP2C17, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 18; cytochrome P450 2C18; CPCI; CYP2C; P450IIC17; CYP2C 18; (S) mephenytoin hydroxylase associated cytochrome P450; CYP2C17; CYPIIC18; Cytochrome P450 family 2 subfamily C polypeptide 18; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 17; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 18; Flavoprotein linked monooxygenase; Microsomal monooxygenase; Unspecific monooxygenase; cytochrome P450-6B/29C; flavoprotein-linked monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; P450-6B/29C
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2C18-1195H Recombinant Human CYP2C18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP2C18-29H Recombinant Human CYP2C18 Protein E.coli
    Human CYP2C18-77H Recombinant Human CYP2C18 Protein E. coli
    Human CYP2C18-2261H Recombinant Human CYP2C18 Protein, GST-tagged Wheat Germ GST
    Human CYP2C18-3396H Recombinant Human CYP2C18 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP2C18-434HCL Recombinant Human CYP2C18 cell lysate N/A
    Rhesus Macaque CYP2C18-1147R Recombinant Rhesus monkey CYP2C18 Protein, His-tagged Mammalian Cell His
    Chicken CYP2C18-1153C Recombinant Chicken CYP2C18 Mammalian Cell His

    cyp2c18 involved in several pathways and played different roles in them. We selected most pathways cyp2c18 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp2c18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations UGT1B3; SULT1ST6; CYP51A1; PRKRA; SULT1B1; CYP4F22; DPEP2; GSTK1; CYP1A2; ACY3
    Chemical carcinogenesis UGT1A3; CYP3A7; ALDH1A3; CYP2C9; CYP2A13; GSTA3; UGT2B7; GSTM7; CYP2C39; FAM84B
    Cytochrome P450 - arranged by substrate type CYP3A7; CYP2U1; CYP2AD3; CYP11B1; CYP3A4; FAM84B; CYP2C19; FDXR; CYP2K18; CYP27B1
    FOXA1 transcription factor network AP1B1; POU2F1; TFF1; DSCAM; NFIA; NFIC; FOXA1; NRIP1; NR2F2; CYP2C18
    Metabolic pathways PTGES2; IDH3G; AGLA; LDHB; B4GALT6; ALG11; PLD2; CYP2J6; ACOX2; DAD1
    Metabolism NUDT3; CYP19A1; ACOT9.2; CKM; PTGDSA; UCP2; SPRB; ABHD14B; NUDT4; ARSF
    Phase 1 - Functionalization of compounds CYP3C4; CYP2R1; CYP2V1; CYP2Y3; CYP27B1; CYP2AD6; CES1; CYP2N13; CYP2K22; CYP3A7
    Retinol metabolism CYP2C18; UGT2B7; SDR16C5A; CYP4A12A; CYP2C37; ALDH1A1; RPE65; SDR16C5; SDR16C5B; ALDH1A2

    cyp2c18 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp2c18 itself. We selected most functions cyp2c18 had, and list some proteins which have the same functions with cyp2c18. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2D10; CYP2C9; CYP2AA3; CYP2P9; CYP2C55; CYP2J6; CYP2C54; CYP2C8; CYP2Y3; CYP2J2
    aromatase activity CYP2C70; CYP2C9; CYP2C38; FAM84B; CYP2J2; CYP2J6; CYP3A7; CYP2J5; CYP2A13; CYP1A4
    heme binding HBAA; CYP51; CYP26B1; CYP2D10; HBAD; EPX; CYP4A10; CYP7A1; CYP3A43; CYP4F11
    iron ion binding CYP19A1B; AOX1; HIF1AN; BRSK2; HBG2; P4HA1B; MSMO1; CYP2P9; P3H2; CYP2W1
    monooxygenase activity YWHABL; CYP2Y3; CYP3C4; CYP3C1L2; CYP8B3; CYP2X9; CYP21A1; CYP19A1B; FMO1; CYP2K17
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2A6; CYP2Y3; CYP2V1; CYP3A25; CYP2X8; CYP2C8; CYP2AD2; CYP2AA7; CYP2D26; CYP2B6
    oxygen binding CYP2F1; HBBE3; CYP2A12; CYP2Y3; CYP2D9; CYP2C37; CYP2U1; HBB-B2; HBE; CYP2R1
    steroid hydroxylase activity CYP2A4; CYP1A1; CYP2D9; CYP2R1; CYP2U1; FAM84B; CYP2AA12; CYP2K22; CYP2K17; CYP2F1

    cyp2c18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp2c18 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp2c18.

    A2M; SDC2; ECSIT

    Tsuchida, T; Zheng, YW; et al. The Development of Humanized Liver With Rag1 Knockout Rats. TRANSPLANTATION PROCEEDINGS 46:1191-1193(2014).
    Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).

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