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CYP2C8

Official Full Name

cytochrome P450, family 2, subfamily C, polypeptide 8
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
Synonyms

CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Cynomolgus
Human
Rhesus Macaque

Source

E. coli
E.coli
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP2C8-120H	Recombinant Human CYP2C8, GST-tagged	Wheat Germ	GST	1 a.a. - 490 a.a.	Inquiry
Human	CYP2C8-11773H	Recombinant Human CYP2C8, His-tagged	E.coli	His	142-490a.a.	$319 / 25ug
Human	CYP2C8-384H	Recombinant Human CYP2C8	Insect Cell	N/A		Inquiry
Human	CYP2C8-7114HCL	Recombinant Human CYP2C8 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYP2C8-2794H	Recombinant Human CYP2C8 protein, His&Myc-tagged	E.coli	His&Myc	27-490aa	Inquiry
Human	CYP2C8-14H	Active Recombinant Human CYP2C8 Protein	E.coli			Inquiry
Human	CYP2C8-76H	Active Recombinant Human CYP2C8 Protein	E. coli			Inquiry
Human	CYP2C8-109HF	Recombinant Full Length Human CYP2C8 Protein	In Vitro Cell Free System	GST	1 a.a. - 490 a.a.	Inquiry
Cynomolgus	CYP2C8-124C	Active Recombinant Cynomolgus CYP2C8 Protein	E. coli			Inquiry
Rhesus Macaque	CYP2C8-1150R	Recombinant Rhesus monkey CYP2C8 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CYP2C8-975R-B	Recombinant Rhesus Macaque CYP2C8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	CYP2C8-975R	Recombinant Rhesus Macaque CYP2C8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
	Kit-0895	CYP2C8 Green Screening Kit		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CYP2C8 Related Articles

CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arachidonic acid metabolism	PLA2G4F;CYP1B1;LTC4S;ALOX12E;CYP2N13;GGT5;CYP4A12A;ALOX8;CYP2C54
Biological oxidations	CYP2AD6;CYP2K17;CYP3A7-CYP3AP1;MTRR;ADH8B;CYP27B1;SLC35B2;SULT1C4;COMT
CYP2E1 reactions	CYP2A6;CYP2S1;CYP2C8;CYP2A7;CYP2D6;CYP2C9;CYP2Y3;CYP2F1;CYP2B6
Chemical carcinogenesis	CYP3A43;GSTT2;ADH7;CYP1A1;CYP2B19;ALDH3A1;ADH4;GSTM6;CYP1B1
Cytochrome P450 - arranged by substrate type	CYP2F1;CYP11A1;CYP4A11;CYP2K18;CYP2D6;CYP4F12;CYP2U1;CYP51A1;CYP2A6
Drug metabolism - cytochrome P450	ADH6;ADH2-2;GSTK1;ADH1A;CYP2A6;CYP2C8;ADH1B;CYP2C9;CYP2C19
Linoleic acid metabolism	PLA2G2A;CYP2C50;PLA2G4C;PLA2G10;CYP2P6;PLA2G1B;CYP2C39;CYP3A41A;PLA2G5
Metabolic pathways	QPRT;ME1;ACACA;GLDC;NAPRT1;AKR1A1B;PCCB;PAFAH1B2;PI4KA

CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.

Function	Related Protein
(R)-limonene 6-monooxygenase activity	CYP2C19;CYP2C8;CYP2C9
(S)-limonene 6-monooxygenase activity	CYP2C8;CYP2C19;CYP2C9
(S)-limonene 7-monooxygenase activity	CYP2C19;CYP2C8;CYP2C9
arachidonic acid epoxygenase activity	CYP4F18;CYP2AA12;CYP2C19;CYP2P10;CYP2C18;CYP2P8;CYP2D6;CYP2A7;CYP2P6
enzyme binding	ZFHX3;NOP14;STC2;HIST1H2AM;PPP1R3B;A2M;PHB;APOA1;LYN
heme binding	CYP2AA8;HBG2;CYP2AA2;CYP1A2;CYP4F22;CYP7B1;NR1D1;HBB-B2;CYP2C70
iron ion binding	CYP2W1;CYP2AA3;XDH;TYW1B;CYP2S1;CYP2N13;ALKBH8;CYP46A1;CYP2D26
monooxygenase activity	CYP2K17;CYP2AA8;CYP1A1;CYP4A10;CYP2C19;CYP3C4;CYP2AA1;CYP4A12A;MOXD1L
oxidoreductase activity	GSTO1;SARDH;JMJD1C;CYP8B3;IMPDH1A;HSD11B1LA;CYP2C19;PHF2;AKR1C6
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2C9;CYP2C18;CYP2D10;CYP2C70;CYP3C1;CYP2W1;CYP2J5;CYP2J6;CYP2AD3
oxygen binding	CYP2C54;CYP2P6;CYP2X8;CYP2P7;HBA1;CYP19A1;CYP2C8;HBQ1;CYP2A6
steroid hydroxylase activity	CYP2P7;CYP2C19;CYP2E1;CYP2AA4;CYP46A1.3;CYP2K22;CYP2AD2;CYP2C54;CYP2C37

CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.

PGRMC1; A2M; APOE; DNAJB1; LONP1; BLMH; RIN3; MAST1; GABARAPL1; MAP1LC3A

Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).

Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).