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Official Full Name cytochrome P450, family 2, subfamily C, polypeptide 8
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
Synonyms CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20
    • Species :
    • Cynomolgus
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2C8-11773H Recombinant Human CYP2C8, His-tagged E.coli His
    Human CYP2C8-120H Recombinant Human CYP2C8, GST-tagged Wheat Germ GST
    Human CYP2C8-14H Recombinant Human CYP2C8 Protein E.coli
    Human CYP2C8-384H Recombinant Human CYP2C8 Insect Cell N/A
    Human CYP2C8-7114HCL Recombinant Human CYP2C8 293 Cell Lysate HEK293 N/A
    Human CYP2C8-76H Recombinant Human CYP2C8 Protein E. coli
    Cynomolgus CYP2C8-124C Recombinant Cynomolgus CYP2C8 Protein E. coli
    Rhesus Macaque CYP2C8-1150R Recombinant Rhesus monkey CYP2C8 Protein, His-tagged Mammalian Cell His
    Kit-0895 CYP2C8 Green Screening Kit N/A

    cyp2c8 involved in several pathways and played different roles in them. We selected most pathways cyp2c8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp2c8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism CYP2E1; CYP1A2; EPHX2; PLA2G12A; CYP4A11; ALOX12; CYP2P7; PTGIS; MAPKAPK2B; PTGDSA
    Biological oxidations UGT1B2; UGT1B5; AKR1A1; UGT1B1; CYP2F1; CYP2J2; ABHD10; GLYAT; CYP2U1; CYP11B1
    CYP2E1 reactions CYP2E1; CYP2A6; CYP2C8; CYP2D6; CYP2C19; CYP2A7; CYP2C9; CYP2S1; CYP2B6; CYP2A13
    Chemical carcinogenesis CYP2C50; ADH5; GSTM7; UGT1A6; CCBL1; SULT1A3; GSTO1; ADH2-2; CYP2C8; AKR1C2
    Cytochrome P450 - arranged by substrate type CYP2F1; CYP2D6; CYP3A5; CYP2AD2; CYP3A7-CYP3AP1; CYP2A13; CYP4F22; CYP2B6; CYP2K22; CYP24A1
    Drug metabolism - cytochrome P450 CYP2C19; CYP2B6; CYP3A5; ADH1A; CYP2C9; CYP2C8; ADH7; GSTO2; CYP2E1; ADH6
    Linoleic acid metabolism CYP2J6; CYP2C54; CYP2P10; CYP3A25; CYP2C9; PLA2G2D; PLA2G5; CYP2C39; CYP2C50; CYP3A65
    Metabolic pathways CPOX; HMBSA; CES1D; INPP5L; PGM2; MINPP1B; CYP7A1A; CYP2R1; ALDH2.1; AKR1C3

    cyp2c8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp2c8 itself. We selected most functions cyp2c8 had, and list some proteins which have the same functions with cyp2c8. You can find most of the proteins on our site.

    Function Related Protein
    (R)-limonene 6-monooxygenase activity CYP2C19; CYP2C9; CYP2C8
    (S)-limonene 6-monooxygenase activity CYP2C19; CYP2C8; CYP2C9
    (S)-limonene 7-monooxygenase activity CYP2C8; CYP2C9; CYP2C19
    arachidonic acid epoxygenase activity CYP2C8; CYP2AA3; CYP2C38; CYP2A7; CYP2C18; CYP2Y3; CYP2S1; CYP2J2; CYP2AA9; CYP2E1
    enzyme binding UGT1A3; CAT; MSH2; CPSF1; HIST1H2AE; BACE1; JUN; ATF7; TP53; CTNNB1
    heme binding CYP1A; CYP2K17; CYP2D26; PXDN; CYP4F12; HBA-A2; HBG1; HBAE3; CYP2J2; CYP2AD2
    iron ion binding CYP26C1; NOS3; P4HA1B; CYP2X9; CYGB; CYP2C9; CYP2P10; CYP2X10.2; FTL; CYP27B1
    monooxygenase activity CYP2K19; CYP2D10; CYP2E1; FAM84B; CYP2AA9; MICAL2; CYP2K6; CYP2AA1; CYP1A2; CYP2X9
    oxidoreductase activity SCCPDHA; RDH1; GDI2; CBR1L; GMPR2; DHDHL; AKR1C21; CYP3A41A; HSD11B1LA; GPX1B
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2J6; CYP2P7; CYP2D6; CYP2X9; CYP2AA4; CYP2C18; CYP2J5; CYP2K22; CYP2AA3; CYP2AD6
    oxygen binding CYP3A4; CYP2AA3; CYP2X7; CYP2C9; CYP2AA1; CYP2C18; CYP2K16; CYP2E1; CYP2K19; CYP2X9
    steroid hydroxylase activity CYP2AD3; CYP2A4; CYP2C37; CYP2D6; CYP2E1; CYP2AA4; CYP46A1.3; CYP2K6; CYP2A13; CYP2D10

    cyp2c8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp2c8 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp2c8.


    Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
    Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).

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