CYP2C8

  • Official Full Name

    cytochrome P450, family 2, subfamily C, polypeptide 8
  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
  • Synonyms

    CYP2C8;cytochrome P450, family 2, subfamily C, polypeptide 8;cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8;cytochrome P450 2C8;CPC8;CYPIIC8;Cytochrome P450 family 2 subfamily C polypeptide 8;Cytochrome P450 form 1;Cytochrome P450 IIC2;Cytochrome P450 MP-12;Cytochrome P450 MP-20;Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8;Flavoprotein linked monooxygenase;Microsomal monooxygenase;MP 12/MP 20;P450 form 1;P450 IIC2;P450 MP 12/MP 20;S mephenytoin 4 hydroxylase;Xenobiotic monooxygenase;s-mephenytoin 4-hydroxylase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8;MP-12/MP-20

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Cynomolgus
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • Insect Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP2C8-11773H Recombinant Human CYP2C8, His-tagged E.coli Human His 142-490a.a.
CYP2C8-1150R Recombinant Rhesus monkey CYP2C8 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP2C8-120H Recombinant Human CYP2C8, GST-tagged Wheat Germ Human GST 1 a.a. - 490 a.a.
CYP2C8-384H Recombinant Human CYP2C8 Insect Cells Human Non
CYP2C8-7114HCL Recombinant Human CYP2C8 293 Cell Lysate HEK293 Human Non
CYP2C8-109HF Recombinant Full Length Human CYP2C8 Protein In Vitro Cell Free System Human GST Full L. 1 a.a. - 490 a.a.
CYP2C8-124C Active Recombinant Cynomolgus CYP2C8 Protein E.coli Cynomolgus
CYP2C8-14H Active Recombinant Human CYP2C8 Protein E.coli Human
CYP2C8-2794H Recombinant Human CYP2C8 protein, His&Myc-tagged E.coli Human His&Myc 27-490aa
CYP2C8-76H Active Recombinant Human CYP2C8 Protein E.coli Human
CYP2C8-975R Recombinant Rhesus Macaque CYP2C8 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP2C8-975R-B Recombinant Rhesus Macaque CYP2C8 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Kit-0895 CYP2C8 Green Screening Kit Non

    Involved Pathway

    CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations PRKRA,CYP4F22,CYP2Y3,UGT1B5,CYP2J2,GGTLC1,CYP1B1,SLC35B3,FAM84B,UGT1B2
    Arachidonic acid metabolism CYP2P8,GPX1,CYP2N13,FAAH2A,PLA2G2A,GGTLC1,CYP2C45,PLA2G4B,PLA2G4AA,PTGIS
    Drug metabolism - cytochrome P450 CYP2C9,ADH4,ADH1A,CYP2A6,ADH2-2,CYP3A5,ADH1B,ADH1C,ADH5,CYP2B6
    Metabolic pathways NDUFB8,CYP2B19,UQCRFS1,GCNT4,ACO2,PLA2G2A,CERS2A,ACSL3A,ATP6V1G3,ATP6V1E1
    Chemical carcinogenesis HSD11B1,ALDH3B2,EPHX1,ALDH3B1,GSTM2,CYP3A41A,ADH1C,CYP2E1,GSTM7,MGST2
    Cytochrome P450 - arranged by substrate type CYP3A5,CYP2A7,CYP2N13,CYP2K19,CYP7A1,CYP17A1,CYP26A1,CYP2D6,CYP2R1,CYP2E1
    CYP2E1 reactions CYP2S1,CYP2A6,CYP2C9,CYP2A13,CYP2E1,CYP2C19,CYP2B6,CYP2F1,CYP2D6,CYP2A7
    Linoleic acid metabolism CYP2J6,ALOX15,PLA2G4D,PLA2G4A,CYP2C55,PLA2G2E,PLA2G12A,CYP2C37,CYP2C70,CYP2P8

    Protein Function

    CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity,(S)-limonene 6-monooxygenase activity,(S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2C18,CYP2N13,CYP4F2,CYP2C70,CYP2AD3,CYP2AD6,CYP2P7,CYP2C54,CYP2P10,CYP2E1
    steroid hydroxylase activity CYP1A1,CYP46A1,CYP2W1,CYP27A1,CYP2A7,CYP2K18,CYP2P6,CYP2X9,CYP2E1,CYP2N13
    enzyme binding MSH3,HDAC1,ZFHX3,MAPK14,TOP2B,ATP2A2,CBS,HDAC3,TSPAN15,PAWR
    (S)-limonene 7-monooxygenase activity CYP2C9,CYP2C19
    oxidoreductase activity DHRS12,DMGDH,RFESD,CYP2AA4,CYP3C1,ADH8B,AIFM3,BCO2L,CYP46A1.1,DHRS7B
    (R)-limonene 6-monooxygenase activity CYP2C9,CYP2C19
    oxygen binding CYP2P10,CYP2AA9,HBG1,HBAE1,CYP2AA7,HBB-Y,CYP2AA2,HBAA1,CYP2K6,CYP2X7
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2B6,CYP3A25,CYP2C38,CYP1A,CYP2AA1,CYP2AD2,CYP2K19,CYP2P8,CYP2A7,CYP2S1
    (S)-limonene 6-monooxygenase activity CYP2C19,CYP2C9

    Interacting Protein

    CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.

    PGRMC1;A2M;APOE;DNAJB1;LONP1;BLMH;RIN3;MAST1;GABARAPL1;MAP1LC3A

    Resources

    References

    • Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
    • Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).

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