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Official Full Name cytochrome P450, family 2, subfamily R, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
Synonyms CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase; Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC; MGC4663; Vitamin D 25 hydroxylase; OTTHUMP00000231476; cytochrome P450, family 2, R1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2R1-2123H Recombinant Human CYP2R1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP2R1-2269H Recombinant Human CYP2R1 Protein, GST-tagged Wheat Germ GST
    Human CYP2R1-7109HCL Recombinant Human CYP2R1 293 Cell Lysate HEK293 N/A
    Mouse Cyp2r1-2418M Recombinant Mouse Cyp2r1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque CYP2R1-1156R Recombinant Rhesus monkey CYP2R1 Protein, His-tagged Mammalian Cell His

    cyp2r1 involved in several pathways and played different roles in them. We selected most pathways cyp2r1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp2r1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations ACY3; CYP2A6; Sult2a2; CYP2J2; CYP2AD2; CYP2C18; AHCY; GGT6; CYP24A1; FDXR
    Cytochrome P450 - arranged by substrate type CYP2S1; CYP2C8; CYP21A2; CYP3A5; CYP2K19; CYP2W1; CYP27B1; CYP2AD3; CYP4F11; CYP3A4
    Metabolic pathways IMPDH1A; DGKE; FPGT; SLC33A1; ATP6V0C; ST3GAL6; FAHD1; GLCEA; DPM3; UGT1A6B
    Metabolism SAT1B; CSPG5B; CYP26A1; CYP11B1; ARL2; CPNE7; ACOT10; NQO1; ARV1; LYPLA1
    Metabolism of lipids and lipoproteins ARSK; ACOT11A; SACM1LB; THEM5; FIG4; GLTPA; ARSI; SLC25A1A; MED19; ACSF2
    Metabolism of steroid hormones and vitamin D PPP1R2; CYP2R1; AKR1B15; HSD17B11; STARD5; CYP24A1; GC; CYP27B1
    Phase 1 - Functionalization of compounds CYP4F12; CYP2AD2; CYP2A7; CYP2V1; CYP2K17; ADH8B; CYP2K18; CYP8B2; CYP2AD3; CYP2K16
    Steroid biosynthesis LSS; SOAT1; LIPA; CYP51; FDFT1; SC5DL; SQLE; CPN1; CELL; FAXDC2

    cyp2r1 has several biochemical functions, for example, heme binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp2r1 itself. We selected most functions cyp2r1 had, and list some proteins which have the same functions with cyp2r1. You can find most of the proteins on our site.

    Function Related Protein
    heme binding HBAE3; IDO2; TDO2A; CYP4A14; CYP19A1; HBAA1; PGRMC1; HBBE2; CYP7B1; CYP2H1
    iron ion binding CALR; CYP26C1; MSMO1; ALOX5A; PLOD1A; P4HA3; HBB-Y; CYP17A1; AOX4; Scd1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2E1; CYP2A4; CYP2X7; CYP2AD3; CYP2D6; CYP2V1; CYP2AA1; CYP2A7; CYP2AA2; CYP1A2
    oxygen binding CYP2A12; CYP2C50; HBA-X; CYP2X7; NGB; CYP17A1; CYP19A1; CYP2C19; CYP2P10; CYP2B6
    steroid hydroxylase activity CYP2E1; CYP2C9; CYP2AD6; CYP2P10; CYP2B6; CYP2S1; CYP1A1; CYP2C54; CYP2P8; CYP2AA7
    vitamin D3 25-hydroxylase activity CYP2R1; FAM84B; CYP27A1; CYP3A4

    cyp2r1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp2r1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp2r1.

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