CYP2R1

  • Official Full Name

    cytochrome P450, family 2, subfamily R, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.

  • Synonyms

    CYP2R1;cytochrome P450, family 2, subfamily R, polypeptide 1;vitamin D 25-hydroxylase;Cytochrome P450 2R1;Cytochrome P450 family 2 R1;Cytochrome P450 family 2 subfamily R polypeptide 1;EC 1.14.13.15;MGC4663;Vitamin D 25 hydroxylase;OTTHUMP00000231476;cytochrome P450, family 2, R1

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP2R1-1156R Recombinant Rhesus monkey CYP2R1 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP2R1-2269H Recombinant Human CYP2R1 Protein, GST-tagged Wheat Germ Human GST
CYP2R1-7109HCL Recombinant Human CYP2R1 293 Cell Lysate HEK293 Human Non
CYP2R1-2123H Recombinant Human CYP2R1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
CYP2R1-2393HF Recombinant Full Length Human CYP2R1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 501 amino acids
Cyp2r1-2418M Recombinant Mouse Cyp2r1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
CYP2R1-981R Recombinant Rhesus Macaque CYP2R1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP2R1-981R-B Recombinant Rhesus Macaque CYP2R1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYP2R1 involved in several pathways and played different roles in them. We selected most pathways CYP2R1 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP2A7,ADH1C,ADH5,CYP2C18,CYP11B2,GGTLC1,SULT1ST6,NAT2,SLC26A2,CYP3A7
    Steroid biosynthesis NSDHL,CYP51,SOAT1,TM7SF2,FAXDC2,LSS,CEL.1,DHCR24,SQLEA,EBP
    Metabolism BPNT1,SCP2B,COX16,GCHFR,ACAD11,SURF1,SLC25A11,PAOX,FAM96B,NDOR1
    Metabolic pathways IL4I1,APIP,SAT1,GCNT2,ATP5IA,MTMR14,BCKDHA,BCO1L,ST3GAL5,OAT
    Metabolism of steroid hormones and vitamin D CYP24A1,STARD5,AKR1B15,HSD17B11,CYP27B1,GC,PPP1R2
    Cytochrome P450 - arranged by substrate type CYP51A1,CYP2N13,CYP4F11,CYP26A1,CYP4F12,CYP2J2,CYP2K6,CYP3C1,CYP2K19,CYP2S1
    Metabolism of lipids and lipoproteins MED6,AGPAT6,AWAT1,PIK3R6,CERS4A,APOA5,COL4A3BP,MED20,BRSK2,MED9
    Phase 1 - Functionalization of compounds CYP2K22,CYP2A7,CYP2K19,CYP3C4,CES1,CYP2V1,CYP3A7,CYP2F1,CYP2N13,CYP3A7-CYP3AP1

    Protein Function

    CYP2R1 has several biochemical functions, for example, heme binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2R1 itself. We selected most functions CYP2R1 had, and list some proteins which have the same functions with CYP2R1. You can find most of the proteins on our site.

    Function Related Protein
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2C9,CYP19A1,CYP2E1,CYP2A6,CYP2AA6,CYP2J6,CYP2B6,CYP2K16,CYP3C1,CYP2F1
    steroid hydroxylase activity CYP2C8,CYP2C9,CYP2K19,CYP2AD3,CYP2D26,CYP1A1,CYP2B19,CYP2P9,CYP2U1,CYP2A13
    iron ion binding CYP2X10.2,ALOX12B,HIF1AN,TPH1B,CYP2V1,PHF8,ISCU,HBAA,CYP2J5,CYP4B1
    heme binding CYP39A1,CAT,CYP4F22,CYP3C4,GUCY1A3,CYP27C1,CYP46A1.4,CYP26A1,CYP11B1,EPX
    vitamin D3 25-hydroxylase activity CYP27A1,CYP3A4,FAM84B
    oxygen binding HBE1,CYP2S1,CYP2C18,HBZ,CYGB2,CYGB,CYP2D26,TH,CYP2AA2,BA1

    Interacting Protein

    CYP2R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2R1.

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