Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

CYP4B1

Official Full Name

cytochrome P450, family 4, subfamily B, polypeptide 1
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene.
Synonyms

CYP4B1; cytochrome P450, family 4, subfamily B, polypeptide 1; cytochrome P450, subfamily IVB, polypeptide 1; cytochrome P450 4B1; CP4B1_HUMAN; CYPIVB1; Cytochrome P450-HP; P450HP; microsomal monooxygenase; P-450HP;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP4B1-2281H	Recombinant Human CYP4B1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP4B1-7104HCL	Recombinant Human CYP4B1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYP4B1-2441HF	Recombinant Full Length Human CYP4B1 Protein, GST-tagged	In Vitro Cell Free System	GST	512 amino acids	Inquiry
Human	CYP4B1-6234H	Recombinant Human CYP4B1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Cyp4b1-2421M	Recombinant Mouse Cyp4b1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	CYP4B1-1749R	Recombinant Rat CYP4B1 Protein	Mammalian Cell	His		Inquiry
Rat	CYP4B1-1408R	Recombinant Rat CYP4B1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CYP4B1-1408R-B	Recombinant Rat CYP4B1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
CYP4B1 Related Articles

CYP4B1 involved in several pathways and played different roles in them. We selected most pathways CYP4B1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arachidonic acid metabolism	PTGIS;GGT5;CYP2P8;ALOX12;CYP2C9;PTGDSA;PLA2G3;CBR1;ALOX5
Biological oxidations	CYP27A1;CYP2A6;CYP4F11;ADH1A;CYP2D6;SLC35B2;ACY3;CYP2K17;SULT1C4
Cytochrome P450 - arranged by substrate type	CYP11B1;FDX1;CYP4A11;CYP2C9;FDX1L;CYP2Y3;CYP2C8;CYP2K6;CYP2U1
Eicosanoids	CYP4B1;CYP4F11;CYP4A11;CYP4F22;CYP4F12
Fatty acids	CYP4B1;CYP2N13;CYP2A7;CYP4F12;CYP4F11;CYP2AD6;CYP2A13;CYP2J2;CYP2F1
Metabolism	COX7C;PLIN2;COX5B;CTH;TYMP;GPAT2;GGTLC1;CPNE3;SLC25A10
Metabolism of lipids and lipoproteins	MED9;PEMT;SLCO1B1;TPTE;DPEP2;AGPAT6;ACOT9.1;GLTPD1;CYP2Y3
Miscellaneous substrates	CYP2S1;CYP2K6;CYP2W1;CYP2K22;CYP2K16;CYP2K18;CYP2K8;CYP4F11;CYP3C4

CYP4B1 has several biochemical functions, for example, aromatase activity, drug binding, fluorene oxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4B1 itself. We selected most functions CYP4B1 had, and list some proteins which have the same functions with CYP4B1. You can find most of the proteins on our site.

Function	Related Protein
aromatase activity	CYP2C39;CYP1A4;CYP2C38;CYP2H1;CYP4F12;FAM84B;CYP4B1;CYP1A1;CYP4A12A
drug binding	CHRM2;FNTB;HTR2B;PPARD;DHODH;P2RX4;CYP2C9;ACE;TYMS
fluorene oxygenase activity	CYP4B1;DEGS1
heme binding	CYP2P10;CYP7A1;HMOX1;CYP2AD3;CYP2P8;CYP1C1;HBE;CYP4T8;CYP2A7
iron ion binding	CYP27C1;CYP2P10;AOX1;CYP21A2;CYP2D9;CYP19A1;CYP2P8;ALOX5;CYP2X7
oxygen binding	CYP2AA7;CYP2C37;CYP2B6;HBB-B2;CYP2C55;HBAA;CYP2C54;CYP2W1;HBM

CYP4B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4B1.

DFFA

Milic, NL; Ngo, SNT; et al. Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 153:60-66(2011).

Dorrenhaus, A; Muller, T; et al. Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers. ARCHIVES OF TOXICOLOGY 81:19-25(2007).