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Official Full Name cytochrome P450, family 4, subfamily B, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene.
Synonyms CYP4B1; cytochrome P450, family 4, subfamily B, polypeptide 1; cytochrome P450, subfamily IVB, polypeptide 1; cytochrome P450 4B1; CP4B1_HUMAN; CYPIVB1; Cytochrome P450-HP; P450HP; microsomal monooxygenase; P-450HP
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cyp4b1-2421M Recombinant Mouse Cyp4b1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CYP4B1-6234H Recombinant Human CYP4B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP4B1-2281H Recombinant Human CYP4B1 Protein, GST-tagged Wheat Germ GST
    Human CYP4B1-7104HCL Recombinant Human CYP4B1 293 Cell Lysate HEK293 N/A
    Rat CYP4B1-1749R Recombinant Rat CYP4B1 Protein Mammalian Cell His

    cyp4b1 involved in several pathways and played different roles in them. We selected most pathways cyp4b1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp4b1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism CYP1A2; CYP2B19; GGTLC1; CYP2P9; PLA2G4C; PTGS2B; PTGS2; CYP4A11; CYP4B1; PLA2G2F
    Biological oxidations CYP7A1; CYP1A1; CYP2N13; TPMT.2; CYP2F1; NAT2; CYP3A7-CYP3AP1; SULT1B1; CYP27B1; UGT1B5
    Cytochrome P450 - arranged by substrate type CYP2F1; CYP2Y3; CYP17A1; CYP3A7-CYP3AP1; CYP4A11; CYP4F11; CYP2K8; CYP3A4; FDXR; CYP7A1
    Eicosanoids CYP4B1; CYP4A11; CYP4F11; CYP4F12; CYP4F22
    Fatty acids CYP4A11; CYP4T8; CYP2AD3; CYP2A7; CYP2V1; CYP4F12; CYP4F22; CYP2F1; CYP2J2; CYP2B6
    Metabolism MED10; CKM; GRHL1; CYP4F11; MTF1; ATP5L; DPEP2; APOA4A; GRX2; DGAT1B
    Metabolism of lipids and lipoproteins FA2H; CYP27B1; GPAT2; DPEP2; FABP11A; CHKB; CTGF; FABP12; CEPT1; MED26
    Miscellaneous substrates CYP2K19; CYP2W1; CYP2K6; CYP4B1; CYP2K18; CYP2K16; CYP3C1; CYP2S1; CYP2U1; CYP4F22

    cyp4b1 has several biochemical functions, for example, aromatase activity, drug binding, fluorene oxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp4b1 itself. We selected most functions cyp4b1 had, and list some proteins which have the same functions with cyp4b1. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP2C38; CYP2D9; CYP4Z1; CYP3A7; CYP2J6; CYP4X1; CYP1A1; CYP2A7; CYP2C18; CYP2D6
    drug binding TLR7; CHKA; FOLR1; PYGL; DHODH; PPARD; FASN; ABP1; Alb; TYMS
    fluorene oxygenase activity CYP4B1; DEGS1
    heme binding TDO2; BA1; IRGM1; CYP4Z1; PTGS2; CYP2K17; PTGIS; CYP1C2; CYP3C1; CYP2D26
    iron ion binding CYP46A1.1; CYP4F2; CYP2AA6; CYP17A1; CYP39A1; CYP2W1; CYP1A4; CYP2AA12; HBD; CYP2D9
    oxygen binding HBAD; CYP2K22; CYP2A4; HBB; CYP2J2; CYGB1; HBD; Adgb; CYP2J5; CYP2B19

    cyp4b1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp4b1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp4b1.


    Milic, NL; Ngo, SNT; et al. Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 153:60-66(2011).
    Dorrenhaus, A; Muller, T; et al. Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers. ARCHIVES OF TOXICOLOGY 81:19-25(2007).

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