CYP4B1
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Official Full Name
cytochrome P450, family 4, subfamily B, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. -
Synonyms
CYP4B1;cytochrome P450, family 4, subfamily B, polypeptide 1;cytochrome P450, subfamily IVB, polypeptide 1;cytochrome P450 4B1;CP4B1_HUMAN;CYPIVB1;Cytochrome P450-HP;P450HP;microsomal monooxygenase;P-450HP
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP4B1-1749R | Recombinant Rat CYP4B1 Protein | Mammalian Cells | Rat | His |
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| CYP4B1-2281H | Recombinant Human CYP4B1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP4B1-7104HCL | Recombinant Human CYP4B1 293 Cell Lysate | HEK293 | Human | Non |
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| CYP4B1-1408R | Recombinant Rat CYP4B1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| CYP4B1-1408R-B | Recombinant Rat CYP4B1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Cyp4b1-2421M | Recombinant Mouse Cyp4b1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| CYP4B1-2441HF | Recombinant Full Length Human CYP4B1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 512 amino acids |
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| CYP4B1-6234H | Recombinant Human CYP4B1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
CYP4B1 involved in several pathways and played different roles in them. We selected most pathways CYP4B1 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Eicosanoids | CYP4A11,CYP4F12,CYP4F22,CYP4F11 |
| Miscellaneous substrates | CYP4F11,CYP2K8,CYP3C1,CYP2K18,CYP2K17,CYP2U1,CYP2K6,CYP2K16,CYP2K19,CYP2S1 |
| Metabolism | HIBADHA,KIAA1199,ELA2,MED7,LSM1,ACOT7,Sult2a6,CYP11B1,OAZ1,CERS4A |
| Cytochrome P450 - arranged by substrate type | CYP3A7-CYP3AP1,FDX1,CYP2B6,CYP21A2,CYP2R1,CYP4T8,CYP2K22,CYP2J2,CYP2F1,CYP1B1 |
| Metabolism of lipids and lipoproteins | PNPLA8,ECI1,CYP46A1,SLC25A1,ACAD11,CYP24A1,ACER1,CSNK1G2,ALOX5B.2,ACOT6 |
| Arachidonic acid metabolism | CYP4F14,PLA2G2A,FAM213B,CYP4A14,ALOX12B,PLA2G16,CBR3,GGT1,CYP2C55,PLA2G2E |
| Fatty acids | CYP2J2,CYP4T8,CYP4F11,CYP2A7,CYP2AD3,CYP2A13,CYP2AD2,CYP2B6,CYP2N13,CYP4A11 |
| Biological oxidations | CES1,ABHD14B,SULT1ST5,SULT1B1,SLC26A1,TPMT.2,CYP2U1,GGT6,ADH1A,CYP3A4 |
Protein Function
CYP4B1 has several biochemical functions, for example, aromatase activity,drug binding,fluorene oxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4B1 itself. We selected most functions CYP4B1 had, and list some proteins which have the same functions with CYP4B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | GUCY1B3,CYP2AA12,CYCS,CYBA,BACH1,CYP11C1,FA2H,CYP2P8,CYP4A14,CYP2AA2 |
| aromatase activity | FAM84B,CYP2D26,CYP3A43,CYP2H1,CYP2C54,CYP1D1,CYP1A2,CYP2C70,CYP2A7,CYP2D6 |
| oxygen binding | CYP2K17,NGB,HBM,CYP2B6,CYP2D6,HBAE3,CYP2AA1,CYP2C55,CYP2K19,MB |
| iron ion binding | CYP2C9,SC5DL,MFI2,CYGB1,CYP51A1,CYP2U1,CYP2A12,CYP21A2,CYP2P10,P4HTM |
| fluorene oxygenase activity | DEGS1 |
| drug binding | FSCN1,HTR1B,PYGL,RARB,PYGB,SRP54B,TOP2A,CHRNB2,CHRNA2,HMGCS1 |
Interacting Protein
CYP4B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4B1.
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References
- Milic, NL; Ngo, SNT; et al. Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 153:60-66(2011).
- Dorrenhaus, A; Muller, T; et al. Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers. ARCHIVES OF TOXICOLOGY 81:19-25(2007).
