CYP4F3
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Official Full Name
cytochrome P450, family 4, subfamily F, polypeptide 3
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Overview
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
CYP4F3; cytochrome P450, family 4, subfamily F, polypeptide 3; cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase) , LTB4H; leukotriene-B(4) omega-hydroxylase 2; CYP4F; CP4F3_HUMAN; CPF3; CYPIVF3; Cytochrome P450 4F3; Cytochrome P450 LTB omega; Cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); Cytochrome P450-LTB-omega; Leukotriene B(4) 20 monooxygenase; Leukotriene B(4) omega hydroxylase; leukotriene B4 omega hydroxylase; Leukotriene-B(4) 20-monooxygenase 2; leukotriene-B4 20-monooxygenase; LTB4H; cytochrome P-450; cytochrome P450, subfamily IVF, polypeptide 3;
- Recombinant Proteins
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CYP4F3-2285H | Recombinant Human CYP4F3 Protein, GST-tagged | Wheat Germ | GST |
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| Human | CYP4F3-28191TH | Recombinant Human CYP4F3 | Wheat Germ | N/A | 99 amino acids |
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| Human | CYP4F3-86H | Active Recombinant Human CYP4F3 Protein | E. coli |
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| Human | CYP4F3-21H | Active Recombinant Human CYP4F3 Protein | E.coli |
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| Homo sapiens (Human) | RFL23570HF | Recombinant Full Length Human Leukotriene-B(4) Omega-Hydroxylase 2(Cyp4F3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-520) |
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| Mus musculus (Mouse) | RFL5894MF | Recombinant Full Length Mouse Leukotriene-B(4) Omega-Hydroxylase 2(Cyp4F3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-524) |
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| Rattus norvegicus (Rat) | RFL23043RF | Recombinant Full Length Rat Leukotriene-B(4) Omega-Hydroxylase 2(Cyp4F3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-524) |
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| Zebrafish | CYP4F3-5626Z | Recombinant Zebrafish CYP4F3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
CYP4F3 involved in several pathways and played different roles in them. We selected most pathways CYP4F3 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP4A12A;CYP2AD2;GPX5;CYP2P10;CYP4F14;ALOX15B;ALOX12E;CYP2P7;CYP2J2 |
| Metabolic pathways | PFAS;MAT2AB;HMBSA;PLCH1;PIGN;PLA2G6;ST6GAL2A;PAPSS2B;RPIA |
CYP4F3 has several biochemical functions, for example, alpha-tocopherol omega-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F3 itself. We selected most functions CYP4F3 had, and list some proteins which have the same functions with CYP4F3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-tocopherol omega-hydroxylase activity | CYP4F2;CYP4F18;CYP4F14;CYP4F3 |
| heme binding | SRC;CYP2C55;HBB-B2;CYP11A1;CYP20A1;CYP2AA12;HEBP1;CAT;CYP8B2 |
| iron ion binding | HBG2;EGLN3;CYP2D6;CYP11A1;ALOX5A;CYP3A5;CYP2C55;CYP39A1;CYP2E1 |
| leukotriene-B4 20-monooxygenase activity | CYP4F18;CYP4F3;CYP4F2;CYP4F12;CYP4A10;CYP4F14;CYP4A11 |
| monooxygenase activity | CYP2K6;CYP2P7;CYP2N13;FMO1;CYP2F1;CYP2V1;CYP7A1A;YWHAE2;CYP2C8 |
CYP4F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F3.
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