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DDX3X

Official Full Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Overview

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog.
Synonyms

ATP dependent RNA helicase DDX3X; DEAD box protein 3 X-chromosomal; DEAD box X isoform; Fibroblast Growth Factor Inducible 14; Fin14; Helicase like protein 2; HLP2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Insect cells
Mamanlian cells
Mammalian Cell
Wheat Germ
Yeast

Tag

Flag
GST
His
Myc
His|B2M
DDK
Myc|DDK
N/A
N
C

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DDX3X-28325TH	Recombinant Human DDX3X protein, GST-tagged	Wheat Germ	GST		$319 / 10ug $498 / 25ug
Human	DDX3X-257H	Recombinant Human DDX3X protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	DDX3X-7007HCL	Recombinant Human DDX3X 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DDX3X-2215H	Recombinant Human DDX3X protein(2-662aa), His&Myc-tagged	Insect cells	N-His&C-Myc	2-662aa	Inquiry
Human	DDX3X-1427HFL	Recombinant Full Length Human DDX3X protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	DDX3X-2222H	Recombinant Human DDX3X Protein (2-662 aa), His-B2M-tagged	E.coli	His/B2M	2-662 aa	Inquiry
Human	DDX3X-2214H	Recombinant Human DDX3X protein, His&Myc-tagged	Yeast	His&Myc	2-662aa	Inquiry
Mouse	Ddx3x-2506M	Recombinant Mouse Ddx3x Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Chicken	DDX3X-2498C	Recombinant Chicken DDX3X	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

DDX3X involved in several pathways and played different roles in them. We selected most pathways DDX3X participated on our site, such as Hepatitis B, RIG-I-like receptor signaling pathway, TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX3X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hepatitis B	STAT5B;FASLG;CCNA2;CXCL8;PRKCB;TGFB1;HSPG2;CCNE1;MAP2K2
RIG-I-like receptor signaling pathway	MAP3K7;NT5C3;DDX3X;IFNPHI3;IFNE;IL-8;NFKBIA;IFNA14;IL12B
TNF-alpha/NF-kB Signaling Pathway	COPS3;ZFAND5;COMMD1;PEG3;CRADD;DPF2;CSNK2A1P;AKAP8;TXLNA
Viral carcinogenesis	NRAS;Casp3;CDK1;KAT2B;PRKACG;HIST1H2BG;SYK;PIK3R1;HDAC1

DDX3X has several biochemical functions, for example, ATP binding, ATP-dependent DNA helicase activity, ATP-dependent RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX3X itself. We selected most functions DDX3X had, and list some proteins which have the same functions with DDX3X. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DYRK1B;WEE1;RPS6KA3B;ACTC1;PTK2;NLRP1;PNCK;UBE2D2A;VWA8
ATP-dependent DNA helicase activity	BLM;CHD1;XRCC6;CHD4;DDX11;FBXO18;RTEL1;ERCC3;DHX9
ATP-dependent RNA helicase activity	DDX25;SNRNP200;DDX23;SKIV2L;DDX47;DDX53;TMEM38A;EIF4A2;DDX3
ATPase activity	PSMC2;DNA2;WRNIP1;ABCG2C;HSPA1A;CENPE;ATAD2B;ABCF3;KIF9
CTPase activity
DNA binding	RAD51C;AKAP8L;CERS2;LIN28A;E2F1;NFRKB;ARNTL;CRY1;NOSTRIN
GTPase activity	TBCC;RAC3;RHEB;IRGE4;RAB42;RAB7L1;RAB39BB;RRAGB;GNAT1
RNA binding	BICC1;KHSRP;IFIT11;RPLP0;OASL2;PRDM14;NHP2L1B;RBM8A;RPLP2
RNA stem-loop binding	DAZAP1;DDX3X;EPRS;CPEB3
eukaryotic initiation factor 4E binding	EIF4EBP3;EIF4EBP2;EIF4G1;HHEX;GRA;EIF4EBP1;OTX2;ANGEL1;DDX3X
mRNA 5-UTR binding	IGF2BP3;DDX3X;MRPS11;IGF2BP1;RPS14;IGF2BP2;LARP1
nucleoside-triphosphatase activity	ENTPD1;ENTPD3;ENTPD8;NTPCR;ENTPD6;DDX3X
poly(A) RNA binding	ATXN2L;KRR1;ELAVL1;LAS1L;MKI67IP;HIST1H4C;SPATS2;PIN4;G3BP2
poly(A) binding	DDX3X;SYNCRIP;HNRNPDL;PAIP2B;RBPMS;KHDRBS1;EIF4A3;PABPC4;TIA1
protein binding	ARHGDIG;ZNF202;TNFSF10;SKAP1;ALDOB;RBM8A;ELANE;NARG2;TNS1
ribosomal small subunit binding	CPEB2;NME1;DHX29;PIM1;DDX3X;ERAL1;NPM1;MTIF3;PTCD3
transcription factor binding	TRAPPC2;MDFIC;CCND1;TRIB2;Trl;PELP1;SMAD2;LCOR;SMARCD3
translation initiation factor binding	EIF3BA;LARP1;ZFP259;TBL2;POLR2GL;DDX3X;POLR2G;EIF2B3;EIF2B4

DDX3X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX3X here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX3X.

p27958-pro_0000037566; PABPC1