DDX46
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
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Overview
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. -
Synonyms
DDX46; DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; probable ATP-dependent RNA helicase DDX46; FLJ25329; KIAA0801; Prp5; PRPF5; PRP5 homolog; RNA helicase; DEAD box protein 46; Prp5-like DEAD-box protein; MGC9936;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Involved Pathway
- Protein Function
- Interacting Protein
DDX46 involved in several pathways and played different roles in them. We selected most pathways DDX46 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | DDX42;SR140;PRPF38A;SRSF5A;SF3B3;SNRPD3L;SF3B2;RP9;SNW1 |
DDX46 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX46 itself. We selected most functions DDX46 had, and list some proteins which have the same functions with DDX46. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TOR1L1;ADCY9;UBE2Q2;ABCG2;NME3;SMARCAD1;CSNK2A1;DCK;CHST13 |
| ATP-dependent RNA helicase activity | EIF4A1B;DDX39;DHX57;DHX9;DHX16;YTHDC2;DQX1;DDX50;TMEM38A |
| poly(A) RNA binding | PCBP2;FLNA;MRM1;PSMD4;VSIG8;DDX18;RBM3;LRRC59;RBM28 |
DDX46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX46 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX46.
SRPK2; NFKB1; RAC3; SF3A2; Sf3a1; recC; rpoB; ssrna_ag; SNW1
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