DGKQ

  • Official Full Name

    diacylglycerol kinase, theta 110kDa
  • Overview

    The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
  • Synonyms

    DGKQ;diacylglycerol kinase, theta 110kDa;DAGK4, diacylglycerol kinase, theta (110kD);diacylglycerol kinase theta;DAGK;DAGK7;DGK-theta;DAG kinase theta;diglyceride kinase theta;DAGK4
Cat.# Product name Source (Host) Species Tag Protein Length Price
DGKQ-11959H Recombinant Human DGKQ protein, His-tagged E.coli Human His
DGKQ-522H Recombinant Human DGKQ Mammalian Cells Human His
DGKQ-1336H Recombinant Human DGKQ Protein, His-tagged E.coli Human His Pro584-Ala721
DGKQ-2796H Recombinant Human DGKQ Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
DGKQ-2796H-B Recombinant Human DGKQ Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    DGKQ involved in several pathways and played different roles in them. We selected most pathways DGKQ participated on our site, such as Choline metabolism in cancer,Effects of PIP2 hydrolysis,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G alpha (q) signalling events ABHD6B,OPN4.1,PROKR1,UTS2D,GRP,LTB4R,EDNRAB,RGS18,KISS1,PROKR1A
    Glycerolipid metabolism Akr1b3,AKR1B8,DGKG,CEL.1,LYCAT,AGPAT4,STIL,DGKD,LIPF,LPIN2
    GPCR downstream signaling UTS2,ARHGEF9,EDNRA,EDNRB,CCR1,LPAR1,TRPC7,OPN1MW,QRFP,S1PR1
    Choline metabolism in cancer PDPK1,PIK3CG,MAP2K2,GPCPD1,LYPLA1,PIP5K1C,FOS,KRAS,SLC44A1,WASL
    Gastrin-CREB signalling pathway via PKC and MAPK TRPC6A,ANXA1,DGKA,KISS1,UTS2,PROKR1A,NTS,ARHGEF25,LPAR2B,NMS
    Effects of PIP2 hydrolysis DGKA,ABHD12,DGKG,RASGRP2,DGKB,TAE1,ABHD6B,TRPC3,TRPC7,TRPC6A
    Hemostasis HBBE1.1,KIF3C,SERPINA1L,APOER2,GNA13,EHD1,CLEC1B,BRPF3,GRB14,DOCK9
    Glycerophospholipid metabolism PPAP2D,DGKG,LPCAT4,PHYKPL,LPGAT1,MBOAT2,STIL,LPIN3,DGKAA,GPD1A

    Protein Function

    DGKQ has several biochemical functions, for example, ATP binding,activating transcription factor binding,diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKQ itself. We selected most functions DGKQ had, and list some proteins which have the same functions with DGKQ. You can find most of the proteins on our site.

    Function Related Protein
    kinase binding RB1,EMP2,JAKMIP2,GFAP,CHIA,WWC1,JAKMIP1,STX1A,JAKMIP3,RPS3
    ATP binding PIP5K1B,CDC34B,GSK3B,TBK1,RPS6KC1,GARS,TSSK6,NTRK2B,KIF27,RIPK2
    protein binding FLI1,CDK2AP1,PAWR,BSCL2,CD36,CHRDL2,VASN,RPS27A,ESRRG,INO80
    diacylglycerol kinase activity DGKAA,DGKE,DGKG,TAE1,DGKD,AGK,DGKZ,DGKB,DGKA
    phospholipase binding PARK2,Pla2r1,NEFL,CALM2,SERPINB1A,CALM1,PRKCZ,CALM,WAS,PDPK1
    metal ion binding ITGAM,PPARG,TESK1,ARSI,ZFP36L1,AMY1A,PM20D1,GNA11,SMAD5,TRIM3B
    activating transcription factor binding HDAC4,GATA4,PPARG,EP300,MEF2A,PRDM16,ATOH8,TAF9,HDAC1,EEF1D

    Interacting Protein

    DGKQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKQ here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKQ.

    pi3p

    Resources

    Research Area

    References

    • Nalls, MA; Pankratz, N; et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. NATURE GENETICS 46:989-+(2014).
    • Lessard, CJ; Li, H; et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome. NATURE GENETICS 45:1284-+(2013).

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