DGKQ

  • Official Full Name

    diacylglycerol kinase, theta 110kDa
  • Overview

    The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
  • Synonyms

    DGKQ;diacylglycerol kinase, theta 110kDa;DAGK4, diacylglycerol kinase, theta (110kD);diacylglycerol kinase theta;DAGK;DAGK7;DGK-theta;DAG kinase theta;diglyceride kinase theta;DAGK4
Cat.# Product name Source (Host) Species Tag Protein Length Price
DGKQ-11959H Recombinant Human DGKQ protein, His-tagged E.coli Human His
DGKQ-522H Recombinant Human DGKQ Mammalian Cells Human His
DGKQ-1336H Recombinant Human DGKQ Protein, His-tagged E.coli Human His Pro584-Ala721
DGKQ-2796H Recombinant Human DGKQ Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
DGKQ-2796H-B Recombinant Human DGKQ Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    DGKQ involved in several pathways and played different roles in them. We selected most pathways DGKQ participated on our site, such as Choline metabolism in cancer,Effects of PIP2 hydrolysis,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gastrin-CREB signalling pathway via PKC and MAPK PROKR1,FPR-RS3,GPR132,OPN4A,TAC1,GPR65,QRFPR,LPAR2B,UTS2D,NTS
    Hemostasis SLC7A6,AKAP10,IGF2B,S100A10A,PROCR,WDR1,CFHL2,KIF5A,DOCK2,PDE10A
    Effects of PIP2 hydrolysis TRPC3,ABHD12,ABHD6B,DGKG,RASGRP2,TRPC7,TRPC6A,DGKA,DGKB,PRKCHB
    Choline metabolism in cancer GPCPD1,WASF2,DGKD,WAS,FOS,PRKCB,AKT1,PDGFRB,WASF3,PIK3R3
    G alpha (q) signalling events CYSLTR1,NMB,QRFPR,DGKA,PROKR1,GPR17,OXTRL,TRIO,LPAR2B,PRKCHB
    Glycerolipid metabolism MBOAT2,AGPAT1,LYCAT,LPIN2,DGKB,DGAT2,PPAP2CB,AGK,TAE1,AKR1A1B
    GPCR downstream signaling ANXA1,TAC2,CXCL11.8,GPR65,ARHGEF3,CALCB,TRPC3,FPR-RS6,RLN2,ECT2
    Glycerophospholipid metabolism AGXT2L1,LCAT,PPAP2D,AGPAT9L,GPD1B,ETNK1,PCYT1AA,DGKE,PPAP2A,PLA2G2A

    Protein Function

    DGKQ has several biochemical functions, for example, ATP binding,activating transcription factor binding,diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKQ itself. We selected most functions DGKQ had, and list some proteins which have the same functions with DGKQ. You can find most of the proteins on our site.

    Function Related Protein
    phospholipase binding LMNB1,Pla2r1,PDPK1,SELE,CALM3,CALM1,WAS,CALM2,SERPINB1A,ARHGAP6
    metal ion binding CHEK2,ISG20,LMX1BB,RNASEL,TRAF4B,DYTN,ATX1,CLCA2,CAR5A,ALPPL2
    diacylglycerol kinase activity DGKD,DGKAA,DGKZ,DGKG,DGKB,DGKE,TAE1,AGK,DGKA
    activating transcription factor binding MEF2A,HDAC4,PSIP1,MEF2D,ZFP516,PPARG,HDAC1,MEF2C,RELA,GATA4
    protein binding NPAS2,HTR3A,ZFP932,BLOC1S3,TMEM106B,IGFBP7,ORC4L,AZI2,RNF41,ETV4
    ATP binding RAF1,SUPV3L1,PRKACAB,DDX24,ACTC1A,DALRD3,IKBKB,PSMC4,CLK3,ERCC6L
    kinase binding PER3,CEBPA,PTPN22,SLC2A1,TNFAIP3,PRKAA1,BARD1,PIP5K1A,JAKMIP1,SIT1

    Interacting Protein

    DGKQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKQ here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKQ.

    pi3p

    Resources

    Research Area

    References

    • Nalls, MA; Pankratz, N; et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. NATURE GENETICS 46:989-+(2014).
    • Lessard, CJ; Li, H; et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome. NATURE GENETICS 45:1284-+(2013).

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