DGKQ
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Official Full Name
diacylglycerol kinase, theta 110kDa -
Overview
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. -
Synonyms
DGKQ;diacylglycerol kinase, theta 110kDa;DAGK4, diacylglycerol kinase, theta (110kD);diacylglycerol kinase theta;DAGK;DAGK7;DGK-theta;DAG kinase theta;diglyceride kinase theta;DAGK4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DGKQ-11959H | Recombinant Human DGKQ protein, His-tagged | E.coli | Human | His | ||
| DGKQ-522H | Recombinant Human DGKQ | Mammalian Cells | Human | His |
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| DGKQ-1336H | Recombinant Human DGKQ Protein, His-tagged | E.coli | Human | His | Pro584-Ala721 |
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| DGKQ-2796H | Recombinant Human DGKQ Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| DGKQ-2796H-B | Recombinant Human DGKQ Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
DGKQ involved in several pathways and played different roles in them. We selected most pathways DGKQ participated on our site, such as Choline metabolism in cancer,Effects of PIP2 hydrolysis,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | GPAT2,PHYKPL,LPCAT1,PTDSS2,PLA2G4D,DGKA,CHKA,LYPLA2,GPD1,AGPAT4 |
| Gastrin-CREB signalling pathway via PKC and MAPK | PMCH,GPR4,GCGA,TRPC6A,RGS18,TAE1,GPR132B,NMBA,LPAR2A,OPN4B |
| GPCR downstream signaling | PYYA,CCL35.1,NMS,ADRA2C,MGLL,CCL19A.2,VIP2,PENKA,PROKR1,TRPC6A |
| Choline metabolism in cancer | GRB2,PLA2G4F,DGKD,PIK3R5,MAPK9,RHEB,RPS6KB2,PIP5K1B,MAPK3,NRAS |
| Glycerolipid metabolism | AKR1A1B,LIPCA,LIPC,ALDH9A1B,GPAT2,MBOAT2,DGAT1,LPIN1,ALDH7A1,DGKA |
| Hemostasis | D-AKAP2,SLC7A11,KIF11,ESAMA,RHOGA,ITGB3A,GNA13B,LOC100514666,F3A,SIRPA |
| Effects of PIP2 hydrolysis | RASGRP2,MGLL,DGKA,ABHD12,DGKG,ABHD6B,TRPC7,PRKCHB,TAE1,DGKB |
| G alpha (q) signalling events | NPSR1,UTS2,CYSLTR1,GCGA,DGKG,TRPC6A,TRPC3,FPR-RS3,ARHGEF25,TAC1 |
Protein Function
DGKQ has several biochemical functions, for example, ATP binding,activating transcription factor binding,diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKQ itself. We selected most functions DGKQ had, and list some proteins which have the same functions with DGKQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| activating transcription factor binding | MEF2D,HDAC7,PRDM16,PSIP1,HDAC7A,EP300,ZFP516,TAF9,HDAC4,GATA4 |
| kinase binding | PARK2,STRADA,UBQLN1,CHIA,SLC2A1,WWC2,LDHA,SGOL1,ABI2,HSP90AB1 |
| ATP binding | TRIOA,NADK2,DYRK3,EPRS,MYH8,KARS,CDK11A,PHKG1B,MAPK12B,ABCD1 |
| diacylglycerol kinase activity | TAE1,DGKG,DGKE,DGKB,DGKD,DGKZ,AGK,DGKAA,DGKA |
| metal ion binding | GNA14,SP9,CYP2D9,FTR82,CYB561,RNF169,YY1B,ADPGK,NRP2,TRIM35-24 |
| protein binding | HEBP2,VPS18,HELLS,RAPGEF3,HDAC7A,TAC3,GRIK3,MED14,ROR2,GLI1 |
| phospholipase binding | SELE,SNCA,PTPN11,PRKCZ,CALM,PDPK1,APOC2,CALM2,PARK2,CALM3 |
Interacting Protein
DGKQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKQ here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKQ.
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References
- Nalls, MA; Pankratz, N; et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. NATURE GENETICS 46:989-+(2014).
- Lessard, CJ; Li, H; et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome. NATURE GENETICS 45:1284-+(2013).
