AKR1C4
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Official Full Name
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) -
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. -
Synonyms
AKR1C4;aldo-keto reductase family 1, member C4 (chlordecone reductase;3-alpha hydroxysteroid dehydrogenase, type I;dihydrodiol dehydrogenase 4);CHDR;aldo-keto reductase family 1 member C4;3 alpha HSD;C11;CDR;DD4;HAKRA;MGC22581;3-alpha-HSD1;di
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
AKR1C4 involved in several pathways and played different roles in them. We selected most pathways AKR1C4 participated on our site, such as Benzo(a)pyrene metabolism,Bile acid and bile salt metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary bile acid biosynthesis | CYP39A1,SLC27A5,HSD17B4,SCP2,BRSK2,HSD3B7,SCP2A,CYP46A1,CYP46A1.1,BAAT |
| Metabolic pathways | TPI1,CHDH,NDUFA10,PIP5K1A,GOT2B,CEL.1,ACER1,NDUFS8A,POLE4,CHPF |
| Retinoid metabolism and transport | BCO2A,BCO2,APOM,BCO2L,APOA4B.2,APOA4A,RBP4,APOA4B.1,AKR1C21,CLPS |
| Bile acid and bile salt metabolism | ACOT8,BRSK2,CYP27A1,SLC27A2,CYP7A1,AKR1C2,SCP2B,AKR1C6,CYP46A1,CYP8B2 |
| Metabolism | CKMT2A,AZIN1B,KCNB1,AK8,COX6C,ATP5S,ACY3.2,ACOT11,NFYAL,FABP1B.1 |
| Metabolism of xenobiotics by cytochrome P450 | ADH2-1,PRKRA,CYP2F1,GSTK1,CYP2S1,ADH2-2,AKR1C2 |
| Benzo(a)pyrene metabolism | AKR1A1,CYP1A1,AKR1C2,CYP3A4,FAM84B,CYP1B1 |
| Metabolism of lipids and lipoproteins | PHOSPHO1,NEU3,CLPS,GLIPR1,MED7,GLTPD1,COQ7,PTGR1,SGMS2,SREBF2 |
Protein Function
AKR1C4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity,androsterone dehydrogenase activity,bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C4 itself. We selected most functions AKR1C4 had, and list some proteins which have the same functions with AKR1C4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | AKR1C21,AKR1C6,NDUFS7,DCXR,AKR1C2,CBR1,DHRS4,AKR1C3 |
| retinal dehydrogenase activity | AKR1B8,ALDH8A1,ALDH1A1,AKR1C3,ALDH1A3,AKR1B10,Aldh1a7,AKR1C6 |
| bile acid transmembrane transporter activity | SLCO1A5,SLCO1B1,SLCO1F1,SLCO1B3,SLCO1F3,SLCO1A4,SLCO1B2,SLCO1D1,SLCO1C1,SLCO1F4 |
| androsterone dehydrogenase activity | AKR1C6,AKR1C21,AKR1C3 |
| aldo-keto reductase (NADP) activity | SDR16C6,AKR1C21,H2-KE6,CYB5A,SDR42E1,MIOX,HSD3B5,AKR1C6,AKR1B10,HSD11B1LA |
| electron carrier activity | AKR1B1,SDHC,HAAO,AOX4,GLRX3,NCF1,ASPH,AOX3,QDPR,AKR1A1 |
Interacting Protein
AKR1C4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C4.
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