|Official Full Name||doublesex and mab-3 related transcription factor 2|
|Background||The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila doublesex (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9.|
|Synonyms||DMRT2; doublesex and mab-3 related transcription factor 2; doublesex- and mab-3-related transcription factor 2; terra like protein; Doublesex and mab 3 related transcription factor 2; Doublesex-like 2 protein; DSXL 2; DSXL2; DSXL-2; OTTHUMP00000020964; OTTHUMP00000020965; OTTHUMP00000020966; OTTHUMP00000020967; terra-like protein|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
dmrt2 involved in several pathways and played different roles in them. We selected most pathways dmrt2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dmrt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
dmrt2 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dmrt2 itself. We selected most functions dmrt2 had, and list some proteins which have the same functions with dmrt2. You can find most of the proteins on our site.
|DNA binding||MAP1S; HUWE1; ZFAND5A; NFAT5A; SMC1B; MTF2; LIG4; POLD1; RBM5; ZNF593|
|RNA polymerase II regulatory region sequence-specific DNA binding||RXRA; ALX4; HMX1; MEF2C; SNAI1; RXRG; RELA; ZNF812; RXRB; ONECUT3|
|core promoter proximal region sequence-specific DNA binding||SMAD4; DMRTC1C2; MIXL1; DMRT1; SP3A; CREBBP; DMRTA1; DMRTC2; SP3; DMRT3|
|metal ion binding||ZNHIT6; ANGPT2; PRDM6; ITGAM; EBF3A; ENOPH1; PLCH2; TRIM59; ZNF705A; ZNF549|
|protein homodimerization activity||TCF12; PRPS2; DAXX; PON3; ALDH1A3; PDE2A; UXS1; MYH7; TCF4; UGT1A4|
|sequence-specific DNA binding||RARGA; TRP63; PKNOX1; ZNF205; IRX6; NFE2L2A; DLX4B; SHOX2; CSRNP1; HEY2|
|transcription factor activity, sequence-specific DNA binding||ZFP161; NFIL3-2; ZNF16; TEF; PDX1; PBX3B; SMAD3B; CITED2; TFDP1B; ZKSCAN17|
dmrt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dmrt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dmrt2.