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Official Full Name doublesex and mab-3 related transcription factor 2
Background The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila doublesex (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9.
Synonyms DMRT2; doublesex and mab-3 related transcription factor 2; doublesex- and mab-3-related transcription factor 2; terra like protein; Doublesex and mab 3 related transcription factor 2; Doublesex-like 2 protein; DSXL 2; DSXL2; DSXL-2; OTTHUMP00000020964; OTTHUMP00000020965; OTTHUMP00000020966; OTTHUMP00000020967; terra-like protein
    • Species :
    • Human
    • Mouse
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DMRT2-2710H Recombinant Human DMRT2 Protein, GST-tagged Wheat Germ GST
    Mouse DMRT2-4650M Recombinant Mouse DMRT2 Protein Mammalian Cell His

    dmrt2 involved in several pathways and played different roles in them. We selected most pathways dmrt2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dmrt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    dmrt2 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dmrt2 itself. We selected most functions dmrt2 had, and list some proteins which have the same functions with dmrt2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding ZNF773; SOHLH1; FOXD3; KAT2B; CREBBP; CREB3; PHF21A; ATF1; HMX1; DLX2
    core promoter proximal region sequence-specific DNA binding CXXC1; GATA3; DMRT2A; DMRTC1C2; DMRT2; CREBBP; DMRTA1; PAX2; SP3; DMRT1
    metal ion binding FAHD2B; PPP4CA; ZFP90; SUZ12A; SNAI1; FGD1; IDO2; WBP7; ZNRF3; ZXDC
    protein homodimerization activity USH2A; MASP1; BMPR1A; RNF17; PAH; USF2; CTSE; FGFR1OP; JUP; DST
    sequence-specific DNA binding PAX7A; ASCL1A; NKX2-5; DLX3; POU2F1; BCL11AB; SP5; HOXC5; HOXB2A; FOXO3
    transcription factor activity, sequence-specific DNA binding HOXA2B; TBX18; RBPJA; ZNF792; HNF4A; NR2C2; ZNF394; E2F7; GATA1; NR2F6B

    dmrt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dmrt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dmrt2.

    Shi, Y; Wang, Q; et al. Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis. AQUACULTURE 426:21-30(2014).
    Liu, YC; Ferguson, JF; et al. Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures of Cardiometabolic Diseases. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34:902-912(2014).

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