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DNA2

Official Full Name

DNA replication helicase/nuclease 2
Overview

DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]
Synonyms

DNA2; DNA replication helicase/nuclease 2; DNA2L; PEOA6; hDNA2; DNA replication ATP-dependent helicase/nuclease DNA2; DNA2-like helicase; DNA replication helicase 2 homolog; DNA replication ATP-dependent helicase-like homolog;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mamanlian cells
Mammalian Cell

Tag

Flag
His
His (Fc)
Avi
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DNA2-12048H	Recombinant Human DNA2 protein, His-tagged	E.coli	His	1-350 aa	$319 / 25ug
Human	DNA2-197HCL	Recombinant Human DNA2 HEK293T cell lysate	HEK293T	Myc/DDK		Inquiry
Human	DNA2-3789HFL	Recombinant Full Length Human DNA2, Flag-tagged	Mamanlian cells	Flag		Inquiry
Mouse	DNA2-4664M	Recombinant Mouse DNA2 Protein	Mammalian Cell	His		Inquiry
Mouse	DNA2-2425M	Recombinant Mouse DNA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	DNA2-2425M-B	Recombinant Mouse DNA2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	DNA2-1636C	Recombinant Chicken DNA2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

DNA2 involved in several pathways and played different roles in them. We selected most pathways DNA2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	MCPH1;TERF2;STAG1;FZR1;PRKDC;RBL1;CP110;MAPRE1B;MYC
Cell Cycle, Mitotic	NDEL1B;CSNK2A2;ERCC6L;LEMD3;LIN9;STAG1;CENPQ;CDK11A;CENPK
Chromosome Maintenance	CENPH;TERF2;DNA2;SMARCA5;CENPA;CENPK;POT1;CENPP;APITD1
DNA Double-Strand Break Repair	CHEK1;EYA2;TDP1;PPP4R2;UIMC1;PARP2;RAD1;RAD51AP1;PPP4R2A
DNA Repair	UIMC1;EYA2;DDB1;BRCC3;RHNO1;EYA4;BABAM1;COPS2;COPS4
DNA Replication	MCM10;POLE2;DBF4;PCNA;MCM6;MCM6L;RNASEH2A;POLE;DNA2
DNA strand elongation	DNA2;GINS4;GINS1;GINS3;GINS2

DNA2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, 5-3 DNA helicase activity, 5-flap endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNA2 itself. We selected most functions DNA2 had, and list some proteins which have the same functions with DNA2. You can find most of the proteins on our site.

Function	Related Protein
4 iron, 4 sulfur cluster binding	RSAD1;TYW1B;IREB2;DEM1;NDUFS1;NDUFS8;DDX11;ISCA1;BRIP1
5-3 DNA helicase activity	PEO1;DNA2;C10orf2;ERCC2
5-flap endonuclease activity	DNA2;FAN1;FEN1;SLX1B
ATP binding	MSH5;MARS2;SCYL1;PDPK1B;PSMC1A;BCS1L;MYO3A;BRAF;GM7168
ATPase activity	PSMD6;MYH8;CARNS1;DNA2;KIF2B;CLPX;ABCG2B;NSF;KIF22
DNA binding	HIST1H2B5;NKX6.1;KDM2BA;PML;PBX3B;ZFP319;ZFP287;ZZZ3;ZNF45
DNA helicase activity	MCM5;RAD54B;CHD8;INO80;SUPV3L1;PIF1;MCM3;MCM6L;DNA2
NOT DNA helicase activity	ERCC6;DNA2;ERCC8
helicase activity	EIF4A1A;TDRD9;IFIH1;TDRD12;CHD9;MOV10B.2;DDX3;RAD54L;DQX1
metal ion binding	ANTXR1;PPM1F;CYP2AA8;GART;PVALB2;ALKBH5;GTF3A;VEZF1B;CYBASC3
nuclease activity	EAR5;TMPPE;EAR3;SMG6;MRE11A;DNASE1L3L;REXO4;HARBI1;EXO5
protein binding	SAC3D1;ARHGAP24;LEPROT;E2F8;PRAME;BUB3;C1orf35;FBXW5;DCP2
single-stranded DNA-dependent ATPase activity	RAD51;RAD18;DNA2
site-specific endodeoxyribonuclease activity, specific for altered base	APEX1;DNA2

DNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNA2.

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