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Official Full Name DPH1 DPH1 homolog (S. cerevisiae)
Background Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM;130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation;and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in;synthesis of diphthamide in EEF2 (Liu et al., 2004 (PubMed 15485916)).
Synonyms DPH1; DPH1 homolog (S. cerevisiae); diptheria toxin resistance protein required for diphthamide biosynthesis like 1 (S. cerevisiae) , DPH like 1 (S. cerevisiae) , DPH2L, DPH2L1; diphthamide biosynthesis protein 1; ovarian tumor suppressor candidate 1; OVCA1; DPH-like 1; DPH2-like 1; ovarian cancer-associated gene 1 protein; candidate tumor suppressor in ovarian cancer 1; diphthamide biosynthesis protein 2 homolog-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; DPH2L; DPH2L1; FLJ33211
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DPH1-2128H Recombinant Human DPH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Dph1-586M Recombinant Mouse Dph1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human DPH1-2481H Recombinant Human DPH1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DPH1-2829H Recombinant Human DPH1 Protein, GST-tagged Wheat Germ GST
    Mouse DPH1-4785M Recombinant Mouse DPH1 Protein Mammalian Cell His
    Chicken DPH1-2418C Recombinant Chicken DPH1 Mammalian Cell His
    Zebrafish DPH1-2584Z Recombinant Zebrafish DPH1 Mammalian Cell His

    dph1 involved in several pathways and played different roles in them. We selected most pathways dph1 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, which may be useful for your reference. Also, other proteins which involved in the same pathway with dph1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gamma carboxylation, hypusine formation and arylsulfatase activation DOHH; SUMF2; PROCA; ARSD; PROZ; ARSJ; DPH3; DPH1; ARSF; DNAJC24
    Metabolism of proteins MIA3; KIFC3; TIMM22; FKBP14; CCT6A; KDELR3; CTSH; ADD1; SSPO; CTSG
    Post-translational protein modification NAPB; TRAPPC2L; SAE1; MPDU1A; ARSD; PROZ; DPAGT1; ARSK; SMC6; NANP
    Synthesis of diphthamide-EEF2 DPH3; ATPBD4; DPH2; OTOP2; DPH5; DNAJC24; DPH1; WDR85

    dph1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dph1 itself. We selected most functions dph1 had, and list some proteins which have the same functions with dph1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RBM4; PRDM7; CNOT10; BRMS1; GLS; ILK; Fgf15; PEX16; CSN3; STX10

    dph1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dph1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dph1.


    Kolaj-Robin, O; McEwen, AG; et al. Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongatordependent tRNA modification. FEBS JOURNAL 282:819-833(2015).
    Davydova, E; Ho, AYY; et al. Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2). JOURNAL OF BIOLOGICAL CHEMISTRY 289:30499-30510(2014).

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