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Official Full Name desmoglein 2
Background Desmoglein 2, also known as DSG2, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epitheli
Synonyms DSG2; desmoglein 2; desmoglein-2; CDHF5; HDGC; cadherin family member 5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • NS0
    • NSO
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DSG2-1601H Recombinant Human Desmoglein 2 NSO N/A
    Human DSG2-400H Recombinant Human DSG2 Protein, His-tagged E.coli His
    Human DSG2-512H Recombinant Human DSG2, Fc Chimera NS0 Fc Chimera
    Human DSG2-6807HCL Recombinant Human DSG2 293 Cell Lysate HEK293 N/A
    Mouse Dsg2-41M Recombinant Mouse Dsg2, Fc-tagged NS0 Fc
    Mouse DSG2-4842M Recombinant Mouse DSG2 Protein Mammalian Cell His
    Mouse Dsg2-56M Recombinant Mouse Dsg2 Protein E.coli N/A
    Mouse Dsg2-990M Recombinant Mouse Dsg2 Protein, Fc Chimera NS0 Fc

    dsg2 involved in several pathways and played different roles in them. We selected most pathways dsg2 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with dsg2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptotic cleavage of cell adhesion proteins CTNNB1; DSP; OCLN; CTNNB2; PKP1; PTBP3; DSG2; DSG3; DSG1
    Apoptotic cleavage of cellular proteins STK26; DSG3; DBNLA; DSG2; CASP6L1; BMX; PLECA; PTBP3; VIML; CLSPN
    Apoptotic execution phase DSP; PLECA; CLSPN; ADD1; GAS2; DSG2; CASP6L1; DSG1; DBNLA; VIML
    Arrhythmogenic right ventricular cardiomyopathy CACNG2; DSP; CACNG3; CTNNA1; DSG2; CTNNA2; JUP; DAG1; CDH2; DMD
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA1; LMNA; CACNB3; GJA1; SGCD; SGCG; CTNNA2; CACNG4; CDH2; PKP2
    Programmed Cell Death RIPK3; SATB1; HMGB2A; DBNLB; STK26; GAS2; DAPK1; DSG2; DIABLOB; DSG3

    dsg2 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. Some of the functions are cooperated with other proteins, some of the functions could acted by dsg2 itself. We selected most functions dsg2 had, and list some proteins which have the same functions with dsg2. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding GSNB; SMOC2; ATP2C1; DGKA; S100A2; FLG2; CLSTN3; SLC24A5; CDH12; NCALDA
    cell adhesion molecule binding CADM2; SELL; ITGB2; PVRL2L; MSN; TENM2; POSTN; DSG2; NPTN; ITGAL
    cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication CTNNA3; JUP; DSG2; DSP; DSC2; PKP2

    dsg2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dsg2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dsg2.

    ganglioside_gm1; JUP; Cbx1; DSC2; Trim69; Flot1; PDGFRA; FLNA; MYH9; Bmpr1a; IQGAP1; Tpm1; Actb; ACTR2; Ppp1cb; Jup; DBN1

    Espana, A; Koga, H; et al. Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. EUROPEAN JOURNAL OF DERMATOLOGY 24:174-179(2014).
    Toumi, A; Saleh, MA; et al. Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus. JOURNAL OF DERMATOLOGICAL SCIENCE 70:19-25(2013).

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