DSN1

  • Official Full Name

    DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

  • Overview

    Defects in kinetochore proteins often lead to aneuploidy and cancer. Mis12-Ktw1 is a conserved essential kinetochore protein family. Human Mis13 protein (c20orf172) is one of the several proteins that form Mis12-kinetochore complex and required for chromosome segregation. Mis13 protein also physically interacts with Blinkin/AF15q14 which is required for mitotic checkpoint and chromosome alignment. It is also required for condensin to accumulate at kinetochores.

  • Synonyms

    DSN1;DSN1, MIND kinetochore complex component, homolog (S. cerevisiae);C20orf172, chromosome 20 open reading frame 172;kinetochore-associated protein DSN1 homolog;dJ469A13.2;hKNL 3;kinetochore null 3 homolog (C. elegans);KNL3;MIS13;kinetochore null 3 homolog;hKNL-3;C20orf172;FLJ13346;MGC32987

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Chicken
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    DSN1 involved in several pathways and played different roles in them. We selected most pathways DSN1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RHO GTPase Effectors RHPN1,KTN1,NOXO1,NOXO1A,PRC1B,RANGAP1B,RHOGA,SKA1,NCKAP1,SPC25
    Cell cycle GMNN,ESCO2,CEP76,MASTL,TMEM188,TINF2,YWHAE1,WAPAL,TGFB2,CUL1
    Cell Cycle, Mitotic PHF8,HIST4H4,ITGB3BP,NCAPG,TUBG2,CENPC1,TSGA14,NUF2,CDK11A,ARPP19
    RHO GTPases Activate Formins SPC25,CLIP1,ZW10,RHOC,ZWINT,KNTC1,NDEL1B,CCDC99,MKL1,SGOL2
    Mitotic Prometaphase CENPK,ZW10,NUF2,CCDC99,NUDC,CENPH,SGOL1,PDS5A,CENPC1,SMC2
    M Phase GORASP1,NSL1,INCENP,SMC2,KIF18A,CENPH,NEK7,KNTC1,ENSAB,ZW10
    Mitotic Metaphase and Anaphase ERCC6L,CENPP,SPDL1,NUF2,ZWILCH,CENPK,CCDC99,RANGAP1B,B9D2,CDCA8
    Mitotic Anaphase ITGB3BP,CCDC99,RCC2,SKA1,CENPP,SPC24,NDEL1B,SKA2,SGOL1,NDEL1A

    Protein Function

    DSN1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSN1 itself. We selected most functions DSN1 had, and list some proteins which have the same functions with DSN1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FRMD5,SDCBP2,ZNF217,BMI1,VPS11,MYCBP2,EPHA3,GPATCH8,SNRNP25,ZRANB2

    Interacting Protein

    DSN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSN1.

    ZWINT;MIS12;Casc5;Mis12;CBX5;Bub1;BUB1;Zwint;Dsn1

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