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DUSP7

Official Full Name

dual specificity phosphatase 7
Overview

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK;(mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with;specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain;and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic;processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et;al., 2009 (PubMed 19228121)).
Synonyms

DUSP7; dual specificity phosphatase 7; dual specificity protein phosphatase 7; MKP X; PYST2; dual-specificity phosphatase-7; dual specificity protein phosphatase PYST2; MKPX; DKFZp586F2224;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DUSP7-2946H	Recombinant Human DUSP7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DUSP7-516HCL	Recombinant Human DUSP7 cell lysate		N/A		Inquiry
Human	DUSP7-2812H	Recombinant Human DUSP7 protein, His-tagged	E.coli	His	60-102 aa	$319 / 25ug
Human	DUSP7-4120HF	Recombinant Full Length Human DUSP7 Protein, GST-tagged	In Vitro Cell Free System	GST	320 amino acids	Inquiry
Zebrafish	DUSP7-10163Z	Recombinant Zebrafish DUSP7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DUSP7 Related Articles

DUSP7 involved in several pathways and played different roles in them. We selected most pathways DUSP7 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	PAQR3A;SPTB;CSF2;SPRED3;FGF18B;FGF8B;WDR83;DUSP5;RASGRP1
Activated TLR4 signalling	DHX9;APPB;CHUK;CREB1B;AGER;NOD1;SIGIRR;JUN;S100A12
Axon guidance	KLB;RHOAE;NRP1;DUSP2;SEMA4B;KALRNB;PTK2;FES;EFNA1
Cytokine Signaling in Immune system	IRF2;GBP6;TRIM68;TRIM17;IFI6;EIF4E;ADAR;MARK3;BST2
DAP12 interactions	DUSP4;CD300LB;FGF20A;SIRPB1;PEA15A;TREM1;RASGRP4;JAK1;PRKAR1AA
DAP12 signaling	NRG4;FRS3;DUSP6;FGF20A;SPTB;AGO2;GRAP2B;KBTBD7;SPTBN2
Developmental Biology	MED20;NRP2;CACNG3;CSNK2A2;SCN8A;ARHGEF28;SREBF2;LIN28A;ACTR3
Downstream signal transduction	PTPRA;FGFR1B;MOV10;DAB2IPB;SPRED3;LAMTOR2;JAK1;PEA15;DUSP9

DUSP7 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP7 itself. We selected most functions DUSP7 had, and list some proteins which have the same functions with DUSP7. You can find most of the proteins on our site.

Function	Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activity	DUSP10;SACM1L;DUSP18;SGPP2;TENC1;DUSP16;DUSP5;NT5DC3;SACM1LB
protein binding	ZFP161;SMCO4;BDKRB2;PDE2A;NUCB1;ATXN2;NME5;VAMP1;KEAP1
protein tyrosine phosphatase activity	EYA3;DUSP15;TIMM50;PTPN3;KIAA1274;DUPD1;EVLA;PTPRDB;DUSP11

DUSP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP7.

GHR; SPOP; MAPK1; MAPK14; ubiq_human; UBA1; UBE2D2

Carlos, AR; Escandell, JM; et al. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets. NATURE COMMUNICATIONS 4:-(2013).

Klorin, G; Rozenblum, E; et al. Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines. CANCER GENETICS 206:191-205(2013).