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Official Full Name dual specificity phosphatase 7
Background Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK;(mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with;specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain;and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic;processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et;al., 2009 (PubMed 19228121)).
Synonyms DUSP7; dual specificity phosphatase 7; dual specificity protein phosphatase 7; MKP X; PYST2; dual-specificity phosphatase-7; dual specificity protein phosphatase PYST2; MKPX; DKFZp586F2224
    • Species :
    • Human
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP7-2946H Recombinant Human DUSP7 Protein, GST-tagged Wheat Germ GST
    Human DUSP7-516HCL Recombinant Human DUSP7 cell lysate N/A
    Zebrafish DUSP7-10163Z Recombinant Zebrafish DUSP7 Mammalian Cell His

    DUSP7 involved in several pathways and played different roles in them. We selected most pathways DUSP7 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation PSMD14; DLG4; SPNA2; HBEGF; IL17RD; SLC14A2; DUSP2; DUSP7; NTF7; EGFR
    Activated TLR4 signalling SAA1; MAPKAPK2B; TANK; PELI1; RIPK3; DUSP3B; CHST13; S100B; NOD1; SIGIRR
    Axon guidance ACTR2B; Ntng2; UNC5A; EPHB3A; PPP3CB; EFNB3; MAPK1; DCX; RASGRP1; DPYSL5B
    Cytokine Signaling in Immune system TRIM62; WDR83; IL1RN; LGALS9; DUSP7; IFIT11; JAK3; SPTBN2; RASGEF1A; KPNA5
    DAP12 interactions MARK3; KBTBD7; SIRPB1; IL17RD; PRKAR1AA; NRG2A; SPTB; PEA15; AHCYL1; PEA15A
    Developmental Biology FRS2B; PHB; PAK4; FGF20A; GFRA1; LGI2; DCX; MED7; DAB2IPB; MED9
    Downstream signal transduction RASGRP4; PEA15; FRS2A; CNKSR1; DUSP10; PAQR3A; SPNA1; CRKL; SPTBN1; DAB2IPB

    DUSP7 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP7 itself. We selected most functions DUSP7 had, and list some proteins which have the same functions with DUSP7. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP4; SACM1LB; DUSP9; CTDSPL2B; DUSP2; DUSP18; TENC1; DUSP8A; DUSP21; SACM1LA
    protein binding NEUROD1; RNF2; PTPN3; SRM; KLHL38; PRRC1; MPPED2; UGGT1; STOML2; ATP6V1D
    protein tyrosine phosphatase activity MTMR8; DUSP26; PTPN3; PTPN2; PTENA; SSH3; MTMR1; MDP1; DUSP22; DUSP3B

    DUSP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP7.

    GHR; SPOP; MAPK1; MAPK14; ubiq_human; UBA1; UBE2D2

    Carlos, AR; Escandell, JM; et al. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets. NATURE COMMUNICATIONS 4:-(2013).
    Klorin, G; Rozenblum, E; et al. Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines. CANCER GENETICS 206:191-205(2013).

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