ep300
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  • Official Full Name
  • E1A binding protein p300
  • Background
  • This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
  • Synonyms
  • EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2
Cat.#:EP300-3346HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EP300 Protein, GST-tagged
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Cat.#:EP300-414HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 Protein, His-tagged
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Cat.#:EP300-43HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 Protein, GST-tagged
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Cat.#:Ep300-415MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ep300 Protein, His-tagged
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Cat.#:Ep300-416RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ep300 Protein, His/GST-tagged
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Cat.#:EP300-1584HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, GST-tagged
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Cat.#:EP300-1585HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, GST-tagged
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Cat.#:EP300-202HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EP300 protein, DDK-tagged
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Cat.#:EP300-28677THTag:Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EP300 protein, Flag-tagged
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Cat.#:EP300-28678THTag:
Source (Host):Species:Human
Product nameRecombinant Human EP300
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Cat.#:EP300-28680THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human EP300, FLAG-tagged
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Cat.#:EP300-42HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 protein
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Cat.#:EP300-442HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EP300, His-tagged
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Cat.#:EP300-610HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EP300
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Cat.#:EP300-80HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 protein, His-tagged
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Cat.#:EP300-1481RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EP300 Protein, His-tagged
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Cat.#:EP300-1074HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, 302-531aa
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Involved Pathway

EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
GPR81; ATP2B1; RAP1B; RYR2; FXYD2; VAV1; CREB3L2; OXTR; HHIP; RAC2
HIF- signaling pathway
MKNK1; NOX1; HK3; IFNG; MAP2K2; PDK1; AKT2; INS2; STAT3; AKT1
FoxO signaling pathway
IGF1; NRAS; STK11; TGFBR1; BCL6A; PRKAB1B; PRKAB1; PIK3CA; CCND2; IGF1RA
Cell cycle
PIANP; CCNA1; CTDNEP1A; WAPAL; CUL1B; SMARCA5; RBBP4; CDC6; MASTL; ANAPC5
Wnt signaling pathway
WNT11; PLCB3; VANGL1; PRKCG; RHOAA; SOST; DKK1; PRICKLE2B; CAMK2D1; PRKCA
Notch signaling pathway
KAT2B; MAML1; NOTCH1; NUMBL; RBPJA; MAML2; RBPJL; DVL3A; MARK2; HES1
TGF-beta signaling pathway
ID2B; GDF5; LFT1; INHBC; ZFYVE16; SMAD1; TFDP1; BAMBIA; SMAD6; ID2A
Adherens junction
SNAI2; RAC3A; SMAD2; PTPRM; CTNNB1; CTNNA2; MAPK3; AASS; RAC1; BAIAP2
Jak-STAT signaling pathway
Il4ra; CSH1; IFNA14; IFNE; IL15RA; LIFR; PIK3CD; IFNL3; FHL1; IL2RG
Long-term potentiation
PRKACB; CALML3; ARAF; MAPK1; ATF4; GRIN2D; PPP3CC; RAP1A; PLCB2; PLCB3
Melanogenesis
CALM; GNAIA; GNA11A; GSK3AA; GNA15.4; FZD8; FZD3A; CALM3B; KRAS; WNT4
Thyroid hormone signaling pathway
ITGAV; PLCB2; PRKCA; NOTCH3; ATP1B2; PRKACB; PIK3CB; MED13L; PRKCG; MED1
Glucagon signaling pathway
LDHAL6B; PRKAG1; CALM1; PPP3R2; CALM2; PPP4C; SIK2; CALML5; PKM; ACACB
Huntingtons disease
NDUFB7; NDUFC2; COX4I2; NDUFS7; Casp3; COX7A1; VDAC1; ATP5O; DNAH6; SOD1
Tuberculosis
CALML3; SYK; RFXANK; BCL2; FCGR2C; AKT2; ITGB2L; HLA-DRB4; CEBPG; EP300
Hepatitis B
PIK3CG; Casp3; VDAC3; TBK1; IKBKB; PIK3CB; IKBKG; FASLG; IFNA16; ELK1
Influenza A
EIF2AK2; Fasl; VDAC1; PRSS1; BLA; IFNG; NXF3; HSPA1B; NFKBIB; HLA-DQB1
HTLV-I infection
STAT5A; KAT2B; HLA-B; HLA-DRB4; BAX; ANAPC2; CCND3; PPP3R1; WNT11; XIAP
Herpes simplex infection
IFNA4; IRF7; JAK2A; TLR2-1; Casp3; TLR2; BMA2; IFNA8; TP53; TYK2
Epstein-Barr virus infection
POLR2L; EIF2AK4; PSMD8; PSMC6; PSMC3; POLR3G; SNW1; HLA-DRA; CDK1; HLA-B
Pathways in cancer
WNT10B; CXCL12; FGF13; ITGB1; HDAC2; TRAF3; PRKCA; TCF7L2; Casp3; WNT8A
Viral carcinogenesis
CCND2; MAPKAPK2; TRAF5; PIK3CD; YWHAG; LTBR; HIST1H4D; HDAC3; TTC6; HIST1H4G
MicroRNAs in cancer
TNN; FZD3; TRP53; BRCA1; RPS6KA5; PLAU; SPRY2; TRP63; SHC4; FSCN1
Renal cell carcinoma
AKT1; CUL2; HGF; EPAS1; TCEB1; EP300; VHL; SLC2A1; GRB2; MAP2K2
Prostate cancer
TRP53; CREB3L2; NDRG1; PIK3CB; PIK3CD; TCF7; FOXO1; KRAS; TP53; PTEN

Protein Function

EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DHARMA; KCNH7; OASL1; FOXN4; SSRP1; HJURP; LMX1BB; EEF1D; HER8.2; BSX
Function NF-kappaB binding
Related Protein CDK5RAP3; GSK3B; MTDH; HIF1AN; ANKRD42; NPM1; RELA; FAF1; CDKN2A; SNAI1A
Function RNA polymerase II activating transcription factor binding
Related Protein SMAD3; NCOR1; PITX2; NEUROD1; ATF2; DUSP26; POU1F1; SIN3A; ZFPM1; MAD2L2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FIGLA; EHF; CEBPB; TGIF1; CEBPZ; POU1F1; ZNF253; TTC6; ALS2CR8; FOXK2
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein H2AFZ; SUZ12; RUVBL2; SMAD1; MAZ; TBR1; HNF4A; SMAD5; TRP53; NLRC5
Function SMAD binding
Related Protein PURB; USP15; CTNNB1; SKIB; FOXH1; SKOR1A; ACVR1B; CREBBP; EP300; TCF12
Function acetyltransferase activity
Related Protein CREBBP; MBOAT4; HHAT; KAT2B; AANAT1; Acnat1; CML5; EP300; KAT5; KAT8
Function activating transcription factor binding
Related Protein RELA; HDAC4; SMAD2; ZFP516; PRDM16; TAF9; HDAC1; MEF2C; HDAC7; MEF2A
Function androgen receptor binding
Related Protein KDM4C; FHL2; PRMT2; RNF14; CALR; PIAS1; NCOA1; PARK7; WIPI1; CCNE1
Function bHLH transcription factor binding
Related Protein EP300; SP1; MAP3K10; USF1; TCF21; IKZF4; HAND1; SIRT1; FOXH1; PSMD9
Function beta-catenin binding
Related Protein GSK3B; KLF4; AXIN2; CD2AP; GRIP1; VCL; CTNNA3; PXN; KDM6B; DACT3
Function chromatin DNA binding
Related Protein NKAP; H2AFY2; WBP2; BCL6; PRDM14; MED1; SMAD3; GRHL3; PPARGC1A; AASS
Function chromatin binding
Related Protein HIST2H3C1; RNF20; SHMT2; SIN3A; TCF7L1A; MED12; CDK9; CAPNS2; CSNK2B; TOX2
Function core promoter binding
Related Protein MYOD1; TFAP2C; SAFB; HMGA2; RBMX; NKX3-1; RELB; HDAC5; SFPI1; IFI203
Function damaged DNA binding
Related Protein RPS3; NEIL2; CREBBP; RAD23AB; TRP53; TP53; RAD52; GTF2H3; RAD23A; NEIL3
Function glucocorticoid receptor binding
Related Protein CEBPB; STAT5B; STAT3; NR4A2; EP300; GRIP1; NRIP1; FKBP4; YWHAH; ETS2
Function histone acetyltransferase activity
Related Protein CLOCK; KAT6B; KAT6A; GTF3C4; HTATIP; TAF1; vnc; CREBBP; KAT5; MGEA5
Function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
Related Protein ESCO2; EP300; CEACAM21; KAT2B; NAT8; NAT8B; RHBDL1
Function mitogen-activated protein kinase binding
Related Protein MAPKAPK2; TNIP1; GTF2I; ACE; MAPKAPK5; PLCB4; MAPKAPK2B; CDK5RAP3; EP300; TPR
Function nuclear hormone receptor binding
Related Protein MYOD1; MED1; TACC2; NCOA2; NRIP1; SIRT1; NCOA1; CRX; SMARCD3; SNW1
Function p53 binding
Related Protein ZNF385B; TRP63; TRIAP1; PSME3; EP300; CDKN2A; MDM2; GSK3B; STK11; SETD8
Function peroxisome proliferator activated receptor binding
Related Protein PRMT2; NR0B2; ASXL1; MED1; PPARGC1A; ASXL2; HMGA1-RS1; IKBKG; NFATC4; EP300
Function pre-mRNA intronic binding
Related Protein PRPF8; RBM41; RBM4; EP300; HNRNPA2B1; SOX9; RNPC3
Function protein C-terminus binding
Related Protein DLG3; DDX1; DLG1; ERCC4; PXK; PRDX3; CD2AP; RBFOX1; STIP1; ATXN2
Function protein antigen binding
Related Protein EP300; KLRC2; KLRD1; ITGA4; H2-AB1
Function protein binding
Related Protein BST2; PRPF40A; YWHAZ; AICDA; USP12; SNRNP70; CBY1; SPPL3; DERL2; HSPA12B
Function protein complex binding
Related Protein RXRA; CFLAR; SKIL; BCAP31; RELA; CD2AP; RAD18; PTPRF; NRAS; SREBF1
Function transcription coactivator activity
Related Protein HTATIP2; KMT2E; HAND1; ESR2; TADA2B; COPS5; RXRA; ABT1; USP22; MED26
Function contributes_to transcription coactivator activity
Related Protein PHF2; EP300; CREBBP; ARID5B
Function transcription factor binding
Related Protein ERCC3; ESRRB; FOXO4; SMARCA4; JUN; EP300; SNF8; DIP2C; LCOR; SP100
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein MAFG; MYF6; CREB3L3; ALX1; GATA2A; SLAMF7; LEF1; PAX9; BARX1; SOHLH1
Function transferase activity, transferring acyl groups
Related Protein TGM2B; HGSNAT; DGAT1; KEG1; LIPT2; NMT1A; TGM3; ZDHHC13; CHAC2; HHATLA
Function zinc ion binding
Related Protein PCGF2; SMAD3; LHX2B; TRIM68; RAG1; MARCH3; MARCH1; MKRN3; ZEB1; MICAL2

Interacting Protein

EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.
HIF1A; TP53

EP300 Related Articles

Vieweg, M; Dvorakova-Hortova, K; et al. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. CLINICAL EPIGENETICS 7:-(2015).
Cho, YA; Hong, JS; et al. The role of p300 in the tumor progression of oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE 44:185-192(2015).