ep300
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  • Official Full Name
  • E1A binding protein p300
  • Background
  • This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
  • Synonyms
  • EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2
Cat.#:EP300-3346HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EP300 Protein, GST-tagged
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Cat.#:EP300-414HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 Protein, His-tagged
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Cat.#:EP300-43HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 Protein, GST-tagged
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Cat.#:Ep300-415MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ep300 Protein, His-tagged
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Cat.#:Ep300-416RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ep300 Protein, His/GST-tagged
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Cat.#:EP300-1584HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, GST-tagged
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Cat.#:EP300-1585HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, GST-tagged
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Cat.#:EP300-202HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EP300 protein, DDK-tagged
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Cat.#:EP300-28677THTag:Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EP300 protein, Flag-tagged
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Cat.#:EP300-28678THTag:
Source (Host):Species:Human
Product nameRecombinant Human EP300
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Cat.#:EP300-28680THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human EP300, FLAG-tagged
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Cat.#:EP300-42HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 protein
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Cat.#:EP300-442HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EP300, His-tagged
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Cat.#:EP300-610HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EP300
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Cat.#:EP300-80HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 protein, His-tagged
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Cat.#:EP300-1481RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EP300 Protein, His-tagged
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Cat.#:EP300-1074HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, 302-531aa
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Involved Pathway

EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
GNAI1; MLLT4; ACOX1; CALM4; ATP2A2; MAPK3; ATP2B1; LOC100328615; GRIN2C; GRIN2B
HIF- signaling pathway
AKT2; EIF4E2; MTOR; PRKCG; EGLN1; ANGPT1; HK3; VHL; PLCG1; PRKCB
FoxO signaling pathway
SOS1; FBXO25; MAPK8B; NLK2; SETD7; PCK1; INS1; PRKAG1; MDM2; INSR
Cell cycle
CUL1B; ACTR1A; NCAPD3; SETA; WEE1; TMEM188; ESCO1; GMNN; CENPK; GINS1
Wnt signaling pathway
PLCB1; LEF1; WNT1; FZD3B; SERPINF1; BAMBIA; NFATC2; MAPK8B; MYCB; FZD7B
Notch signaling pathway
DTX4; HDAC1; MFNG; RBPJL; NCSTN; MAML1; DLL3; NCOR2; DLL4; HES1
TGF-beta signaling pathway
ACVR1C; RPS6KB1; SMAD2; BMP8B; BMPR1B; RBL1; TGFB2; ACVR1; RHOAB; BAMBIB
Adherens junction
RHOAB; CSNK2A1; LMO7A; MLLT4; RAC3B; PVRL2; ACTN2B; CDH1; FGFR1; SNAI2
Jak-STAT signaling pathway
IL-15RA; PIK3CD; STAT1B; GHRA; IFNA17; IL12BA; PIK3CA; STAM2; IFNA5; IFNA7
Long-term potentiation
GRM5; ATF4; PRKACB; RAP1B; GRM1; CAMK2G; PPP1CA; GRIN2C; GRIN2A; MAP2K2
Melanogenesis
PRKACBA; MITFA; CAMK2B; HRASB; DVL3A; FZD2; WNT8A; GNAS; CREB3L2; WNT11R
Thyroid hormone signaling pathway
FXYD2; ITGB3; BAD; PRKACB; RXRG; MED4; MTOR; HRAS; TBC1D4; RCAN2
Glucagon signaling pathway
PPP3CB; FOXO1; SMEK2; PRKACB; GNAS; PHKG2; PPP3CC; PRKACG; ATF4; AKT2
Huntingtons disease
NDUFA10; ATP5F1; DCTN4; NDUFA4L2; SLC25A6; COX5B; GRIN1; PLCB3; NDUFB2; COX7B
Tuberculosis
HLA-DQB1; CD14; BCL2; CALM4; Casp3; IFNGR2; IL18; IL10RB; ATP6V0D1; IFNB1
Hepatitis B
IL-8; IFNA13; BAD; CREB5; IFNA1; IFNA10; IFNA12; TNF; TLR4; NFATC1
Influenza A
IFNA14; CXCL10; PML; EIF2AK4; MX1; TLR4; LOC100686744; MAPK12; NXT2; PIK3CB
HTLV-I infection
VDAC3; MSX1; RB1; WNT8A; WNT1; POLE3; RRAS2; MYBL1; ITGAL; RANBP3
Herpes simplex infection
BF2; SRSF6B; C3A.2; SRPK1; IFNA13; IFNA17; SFRS9; HLA-A; IFIH1; IFNA8
Epstein-Barr virus infection
PSMD12; IKBKB; PSMC2; AKT1; IL10RA; PIK3CA; YWHAH; CSNK2B; TBPL2; MAP2K7
Pathways in cancer
GSK3B; PLCG1; ITGA2; PLCB3; TRAF5; FH1; STAT1; CUL2; DAPK2; RALB
Viral carcinogenesis
REL; GTF2A2; BAK1; PIK3R2; TRAF3; HNRNPK; SP100; VDAC3; ACTN4; SYK
MicroRNAs in cancer
FSCN1; PTEN; PLCG2; MDM2; PLAU; ABCC1; IRS2; HRAS; Casp3; MAPK7
Renal cell carcinoma
TGFB1; PIK3R2; ARAF; TGFA; RAPGEF1; RAP1A; MAP2K1; RAF1; AKT2; VEGFA
Prostate cancer
NKX3-1; LEF1; CCND1; TRP53; MAP2K1; PIK3CD; FOXO1; TCF7L2; INS2; NRAS

Protein Function

EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein POLR3D; POLR3A; AIFM1; Alb; ZNF7; G3BP1; ZNF764; ALX4; TFAP4; ZNF791
Function NF-kappaB binding
Related Protein COMMD6; BCL10; RNF25; RPS3; AP1S2; HDAC2; PSMA6; CPNE1; NPM1; HDAC1
Function RNA polymerase II activating transcription factor binding
Related Protein LMO2; EP300; TBX20; MAD2L2; HNF4A; EOMES; CREBBP; TP53BP1; NEUROD1; PITX2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZNF562; TBX15; CC2D1A; RBPJA; KLF5; NRL; MYF6; MIXL1; AKNA; YBX1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein MITF; H2AFY; HOXB3; H3F3A; NLRC5; TRP53; EGR1; GATA3; ZNF277; MAZ
Function SMAD binding
Related Protein TGFBR2; COL5A2; TCF12; TGFBR3; CTNNB1; PML; TGFBRAP1; USP15; SKOR1; SKILB
Function acetyltransferase activity
Related Protein LPCAT3; ACNAT2; Nat3; MBOAT4; KAT6B; CML2; KAT5; Acnat1; HHAT; CREBBP
Function activating transcription factor binding
Related Protein SMAD2; ATOH8; TAF9; PRDM16; PPARG; MEF2C; ZFP516; EP300; MEF2A; GATA4
Function androgen receptor binding
Related Protein TRIM68; GRIP1; FOXP1; CALR; FOXH1; NCOA3; TCF21; BRCA1; DAXX; DDX5
Function bHLH transcription factor binding
Related Protein SP1; SMAD3; ASCL1; TCF3A; USF1; TCF12; HAND1; USF2; TCF3; TCF3B
Function beta-catenin binding
Related Protein PTPRK; DVL3; LZIC; TCF7L2; CTNNA1; CBY1; VCL; NUMB; GSK3B; MED12L
Function chromatin DNA binding
Related Protein NOTCH1; MYOD1; GRHL3; THRB; FOXC2; RARA; SLAMF7; MYOG; MED1; HIST1H1C
Function chromatin binding
Related Protein SREBF1; CUX1; PHF21A; SMAD6; ZKSCAN3; HMGB2B; BRD2; NUP62; NR5A1B; ASF1A
Function core promoter binding
Related Protein FOXO3; IFI203; RELB; NKX2-1; HNRNPU; E2F2; HMGA2; CALCOCO1; HDAC5; EP300
Function damaged DNA binding
Related Protein XRCC5; HMGB2; XRCC6; XRCC1; TRP63; POLH; XPC; MGMT; RBBP8; POLD1
Function glucocorticoid receptor binding
Related Protein GRIP1; EP300; CEBPB; FKBP4; STAT5B; NRIP1; ETS2; YWHAH; STAT3; NR4A2
Function histone acetyltransferase activity
Related Protein CREBBP; KAT2B; KAT6A; CSRP2BP; METTL8; TAF1L; GTF3C4; KAT6B; KAT7; MGEA5
Function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
Related Protein NAT8B; CEACAM21; ESCO2; KAT2B; RHBDL1; NAT8; EP300
Function mitogen-activated protein kinase binding
Related Protein ABL1; TNIP1; PTPRJ; MAPK7; EP300; ATF7; TPR; ACE; MAPKAPK2A; CDK5RAP3
Function nuclear hormone receptor binding
Related Protein SMARCD3; CRX; NCOR1; NRIP1; SIRT1; MED1; MYOD1; CRY1; TACC2; ACTN4
Function p53 binding
Related Protein EHMT2; BLM; SETD7; ZFP346; CHD8; PLK3; ZNF385B; ZNF346; TRP63; ZMAT4
Function peroxisome proliferator activated receptor binding
Related Protein NFATC4; IKBKG; HMGA1-RS1; NR0B2; MED1; HMGA1; CREBBP; ASXL2; PPARGC1A; PRMT2
Function pre-mRNA intronic binding
Related Protein PRPF8; RBM41; SOX9; RNPC3; HNRNPA2B1; EP300; RBM4
Function protein C-terminus binding
Related Protein MSH2; VIM; SCLT1; CEP120; PIAS4; TBL1X; TRIM3; ATF4; HRAS; CTNNB1
Function protein antigen binding
Related Protein EP300; KLRD1; H2-AB1; KLRC2; ITGA4
Function protein binding
Related Protein ALPP; AMY1A; ABHD14B; SAP18; MAP1B; G6PD; RINL; A1CF; KIAA0319L; ZNF148
Function protein complex binding
Related Protein PAFAH1B1; TUB; TAPBPL; Cel; AP2A1; AKAP5; Casp3; RELA; NDUFA4; RAN
Function transcription coactivator activity
Related Protein GABPA; BRDT; GRIP1; TUBB3; FHL5; TFDP1; ENY2; MED26; RXRA; PRRX1
Function contributes_to transcription coactivator activity
Related Protein PHF2; EP300; ARID5B; CREBBP
Function transcription factor binding
Related Protein PPP1R13BB; DDX3X; BCL3; SOX10; DRG1; EP300; TCF12; STK4; MLXIPL; CDKN2A
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein BARX1; ONECUT3; HOXD8; FOXO3; LEF1; ZGLP1; NHLH1; STAT3; CTCF; MAFA
Function transferase activity, transferring acyl groups
Related Protein ZDHHC24; ZDHHC15B; DGAT1A; AANAT2; CML2; TGM3; ZDHHC1; GGACT.3; LIPT1; ZDHHC18A
Function zinc ion binding
Related Protein ZFAND3; AMFR; ZFAND4; RNF128A; SIRT6; LNX2B; RARGB; S100B; RARGA; MTF2

Interacting Protein

EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.
HIF1A; TP53

EP300 Related Articles

Vieweg, M; Dvorakova-Hortova, K; et al. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. CLINICAL EPIGENETICS 7:-(2015).
Cho, YA; Hong, JS; et al. The role of p300 in the tumor progression of oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE 44:185-192(2015).