ep300
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  • Official Full Name
  • E1A binding protein p300
  • Background
  • This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
  • Synonyms
  • EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2
Cat.#:EP300-3346HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EP300 Protein, GST-tagged
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Cat.#:EP300-414HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 Protein, His-tagged
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Cat.#:EP300-43HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 Protein, GST-tagged
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Cat.#:Ep300-415MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ep300 Protein, His-tagged
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Cat.#:Ep300-416RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ep300 Protein, His/GST-tagged
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Cat.#:EP300-1584HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, GST-tagged
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Cat.#:EP300-1585HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, GST-tagged
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Cat.#:EP300-202HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EP300 protein, DDK-tagged
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Cat.#:EP300-28677THTag:Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EP300 protein, Flag-tagged
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Cat.#:EP300-28678THTag:
Source (Host):Species:Human
Product nameRecombinant Human EP300
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Cat.#:EP300-28680THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human EP300, FLAG-tagged
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Cat.#:EP300-42HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 protein
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Cat.#:EP300-442HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EP300, His-tagged
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Cat.#:EP300-610HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EP300
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Cat.#:EP300-80HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EP300 protein, His-tagged
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Cat.#:EP300-1481RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EP300 Protein, His-tagged
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Cat.#:EP300-1074HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E1A Binding Protein P300, 302-531aa
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Involved Pathway

EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
GRIA3; RAP1A; PIK3CG; PIK3R3; PAK1; CREB3L3; GPR119; MAPK10; VIPR2; GHSR
HIF- signaling pathway
HIF1A; TEK; PLCG1; TFRC; CAMK2B; PIK3CD; ENO1; ERBB2; IGF1; MAP2K2
FoxO signaling pathway
GRB2B; HRAS; CCNB2; RAG2; RBL2; STK4; Fasl; GADD45AA; NRAS; MAPK14B
Cell cycle
CCNA1; SKP1; CDC14A; ATM; TGFB2; RAD21B; NCAPD3; BORA; TCTN2; HDAC2
Wnt signaling pathway
FZD2; RAC3B; DKK1B; PRKACBA; CAMK2D1; PRKACG; WNT6; GPC4; PRKCBA; PRKCBB
Notch signaling pathway
MAML1; DTX3L; RFNG; NOTCH1; APH1C; JAG1B; KAT2B; CTBP2; ADAM17; MFNG
TGF-beta signaling pathway
TFDP1A; BMPR1BA; FSTA; ACVR1; INHBC; LFT2; SMURF2; TNF; RBL1; TGFBR1A
Adherens junction
RHOAD; CDC42L; WASF2; WASL; RAC1B; CSNK2A1; VCLA; ACTN4; WASF3; SNAI1
Jak-STAT signaling pathway
PIAS4A; IL2RG; IFNG1-2; PIK3R3A; PIM1; IL5RA; GRB2B; IL10RA; CNTFR; IL12RB1
Long-term potentiation
BRAF; PPP3R2; ATF4; PRKCB; MAPK3; HRAS; CAMK2B; PPP1R1A; GRIA1; CALM4
Melanogenesis
PRKCBB; DCT; EP300; NRAS; CREB3L3L; KITLGA; FZD7A; ADCY2B; GNAI2; PRKACAB
Thyroid hormone signaling pathway
TRP53; BAD; FOXO1; KAT2B; PRKACG; MED24; HDAC3; NOTCH4; RXRA; PIK3CG
Glucagon signaling pathway
PRKAB1; LDHAL6A; CAMK2D; CALM4; PPP3CB; GNAS; CALM3; GCGR; SLC2A2; PGAM2
Huntingtons disease
SLC25A6; POLR2K; GPX1; POLR2C; UQCRC1; DCTN2; UQCRQ; SDHB; COX6B2; NDUFS7
Tuberculosis
CD209B; PPP3R2; ARHGEF12; RAF1; Il23a; Il12b; BAD; CD209C; Pla2r1; IFNA10; IFNA13
Hepatitis B
MAP2K4; DDB2; TICAM2; CREB3L2; TGFB3; YWHAZ; EP300; Ifna15; CCNE1; APAF1
Influenza A
XPO1; CPSF4; HSPA6; LOC100033925; STAT2; IL-8; SLC25A6; OAS1A; LOC100686744; HSPA1B
HTLV-I infection
APC; WNT1; TGFB3; ANAPC11; HLA-C; ANAPC4; CRTC2; MAP3K1; DLG1; PDGFRB
Herpes simplex infection
CYCS; IFNB1; CRFB2; IRF7; SRSF1A; CUL1B; STAT1A; IKBKB; IL12B; NXF3
Epstein-Barr virus infection
TBK1; CD44; GTF2E2; CR2; HLA-G; TBPL2; PSMD6; H2-Q10; MAP2K4; EP300
Pathways in cancer
STAT1; PLCB4; WNT9A; FGF16; GNB2; FGF12; ITGA6; SKP2; TRAF5; TFG
Viral carcinogenesis
HNRNPK; GTF2A2; ACTN2; IKBKG; HRAS; GRB2; RAC1; GTF2H3; HIST1H2BA; POLB
MicroRNAs in cancer
DNMT3B; NOTCH1; UBE2I; PDGFRB; RASSF1; FGFR3; TRP63; CD44; Abcb1b; TIMP3
Renal cell carcinoma
TGFB3; PAK6; PAK1; AKT2; TGFB1; RAPGEF1; TCEB1; GAB1; PTPN11; RAF1
Prostate cancer
NDRG1; MAP2K2; PDPK1; MTOR; Ar; CREB5; IKBKB; NRAS; INS1; TCF7

Protein Function

EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein POU3F3A; FOXF2; ZBTB44; DRL; DEK; AHDC1; FOXG1C; PCXB; ZFP523; ZNF529
Function NF-kappaB binding
Related Protein MTDH; HDAC1; GSK3B; CPNE1; COMMD6; PSMA6; NFKBID; COMMD7; BRMS1; RELA
Function RNA polymerase II activating transcription factor binding
Related Protein ISL1; BEX1; CREB1; ZFPM1; BHLHE40; NHLH2; RB1; IFI27; HIPK2; POU1F1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NFATC2; BATF; NDN; ATOH1; HIST2H3A; HINFP; NPAS4; ZNF264; MED8; HOXD13
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein IRF7; HOXB3; RUNX2; ZFPM1; MTF1; NFIL3; SMYD3; TBR1; GATA6; SMAD1
Function SMAD binding
Related Protein FOXH1; TGFBR3; SKILB; CTNNB1; RNF111; TGFBR1; AXIN1; SMURF2; HIPK2; SKIL
Function acetyltransferase activity
Related Protein HHAT; Nat3; CML5; AANAT1; ACNAT2; KAT6B; AANAT2; KAT8; MBOAT4; MBOAT7
Function activating transcription factor binding
Related Protein DGKQ; PRDM16; HDAC1; MEF2A; HDAC7A; HDAC4; SMAD2; MEF2C; MEF2D; HDAC7
Function androgen receptor binding
Related Protein KAT5; PIAS2; CCNE1; CDK7; PRKCB; RNF14; NSD1; NCOA4; EP300; KDM1A
Function bHLH transcription factor binding
Related Protein HAND1; TCF4; TCF3; PSMD9; ISL1; SMAD3; SP1; TCF12; FOXH1; SOX9
Function beta-catenin binding
Related Protein SMAD3; SLC9A3R2; TAX1BP3; CD2AP; SHROOM2; SOX17; APC2; HDAC6; BCL9; GLI3
Function chromatin DNA binding
Related Protein VAX1; RXRA; FOXC2; SMAD3; PER1; RUVBL2; THRA; THRB; NKAP; VAX2
Function chromatin binding
Related Protein GPR30; HINFP; TRP63; TCF7L1A; NONO; EBF2; ORC1L; SOX9A; SKIL; NIPBL
Function core promoter binding
Related Protein PYDC3; MED1; INSM1A; CLOCK; MTF1; GADD45A; RBMX; NKX3; MTA1; MYOG
Function damaged DNA binding
Related Protein ERCC1; APEX1; MPG; XRCC5; RAD23A; DCLRE1C; TP63; TP53BP1; FEN1; ERCC3
Function glucocorticoid receptor binding
Related Protein CEBPB; EP300; NRIP1; STAT5B; NR4A2; ETS2; STAT3; YWHAH; GRIP1; FKBP4
Function histone acetyltransferase activity
Related Protein CDYL; vnc; KAT5; CLOCK; MED24; GTF3C4; NCOA3; CSRP2BP; KAT6B; NCOA2
Function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
Related Protein EP300; CEACAM21; RHBDL1; ESCO2; KAT2B; NAT8; NAT8B
Function mitogen-activated protein kinase binding
Related Protein MAPK7; MICALCL; MAPKAPK5; TPR; MAPKAPK2A; ACE; SIRT1; ARRB2; PLCB4; EP300
Function nuclear hormone receptor binding
Related Protein NCOA1; EP300; NRIP1; MED1; NCOR1; TCF7L2; MYOD1; NCOA3; HIF1A; CRX
Function p53 binding
Related Protein ZNF385B; GSK3B; RFWD3; DAXX; TRIAP1; DUSP26; RNF34; HTT; CDK5; TAF3
Function peroxisome proliferator activated receptor binding
Related Protein CREBBP; ASXL2; PPARGC1A; EP300; ASXL1; IKBKG; HMGA1; NR0B2; NFATC4; PRMT2
Function pre-mRNA intronic binding
Related Protein RBM4; SOX9; PRPF8; HNRNPA2B1; RBM41; RNPC3; EP300
Function protein C-terminus binding
Related Protein MLLT4; PFKM; PPM1A; KCNIP3; ERCC3; EP300; ERCC4; SIAH1; GRIP1; COIL
Function protein antigen binding
Related Protein H2-AB1; EP300; KLRC2; KLRD1; ITGA4
Function protein binding
Related Protein SCARA3; CCDC101; CINP; CCDC88A; CDC34; EHMT2; CHRNA5; LUC7L; ITGB2; C7orf49
Function protein complex binding
Related Protein TG; MLC1; HSPD1; Apba1; FBN1; TMED10; PPARA; TULP2; KRIT1; SREBF1
Function transcription coactivator activity
Related Protein NR2F1; NFYC; BCL10; HCFC1; MED13; MYCBP; ATF2; PRDM16; NFATC4; MAX
Function contributes_to transcription coactivator activity
Related Protein EP300; PHF2; ARID5B; CREBBP
Function transcription factor binding
Related Protein TRIM6; HDAC11; BRD7; IGHMBP2; HHEX; TFDP1; HDAC7; KAT2B; PIK3R1; CTNNB1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein SLAMF7; GLIS1; SRF; HIF1A; MAF; IRF2; NEUROD2; OSR2; CTCF; CSRNP1
Function transferase activity, transferring acyl groups
Related Protein HHAT; ZDHHC20A; ZDHHC18A; AGPAT9L; CHATB; ZDHHC16B; GM4952; DGAT1B; MEIS2; ZDHHC23B
Function zinc ion binding
Related Protein FTR72; FHL3; THAP11; CCNB1IP1; THRAA; RNF113A; UQCRC2; NR2F6; MMP30; BTR16

Interacting Protein

EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.
HIF1A; TP53

EP300 Related Articles

Vieweg, M; Dvorakova-Hortova, K; et al. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. CLINICAL EPIGENETICS 7:-(2015).
Cho, YA; Hong, JS; et al. The role of p300 in the tumor progression of oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE 44:185-192(2015).