ERVFRD-1
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Official Full Name
endogenous retrovirus group FRD, member 1 -
Overview
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels,;suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus;provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope;glycoprotein gene which appears to have been selectively preserved. The genes protein product plays a major role in;placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope;protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a;heterodimer. -
Synonyms
ERVFRD-1;endogenous retrovirus group FRD, member 1;HERV-FRD_6p24.1 provirus ancestral Env polyprotein;envFRD;ERVFRDE1;HERV FRD;HERV W/FRD;syncytin 2;envelope polyprotein;endogenous retrovirus group FRD member 1;HERV-FRD provirus ancestral Env po
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ERVFRD-1-3492H | Recombinant Human ERVFRD-1 Protein, GST-tagged | Wheat Germ | Human | GST | 1-538 a.a. |
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| ERVFRD-1-4694HF | Recombinant Full Length Human ERVFRD-1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 538 amino acids |
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Involved Pathway
ERVFRD-1 involved in several pathways and played different roles in them. We selected most pathways ERVFRD-1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ERVFRD-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ERVFRD-1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ERVFRD-1 itself. We selected most functions ERVFRD-1 had, and list some proteins which have the same functions with ERVFRD-1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ERVFRD-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERVFRD-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERVFRD-1.
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References
- Vargas, A; Zhou, SF; et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB JOURNAL 28:3703-3719(2014).
