Recombinant Human F9 Protein, GST-tagged
Cat.No. : | F9-3626H |
Product Overview : | Human F9 full-length ORF ( NP_000124.1, 1 a.a. - 461 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 78.2 kDa |
AA Sequence : | MQRVNMIMAESPGLITICLLGYLLS AECTVFLDHENANKILNRPKRYNSG KLEEFVQGNLERECMEEKCSFEEAR EVFENTERTTEFWKQYVDGDQCESN PCLNGGSCKDDINSYECWCPFGFEG KNCELDVTCNIKNGRCEQFCKNSAD NKVVCSCTEGYRLAENQKSCEPAVP FPCGRVSVSQTSKLTRAETVFPDVD YVNSTEAETILDNITQSTQSFNDFT RVVGGEDAKPGQFPWQVVLNGKVDA FCGGSIVNEKWIVTAAHCVETGVKI TVVAGEHNIEETEHTEQKRNVIRII PHHNYNAAINKYNHDIALLELDEPL VLNSYVTPICIADKEYTNIFLKFGS GYVSGWGRVFHKGRSALVLQYLRVP LVDRATCLRSTKFTIYNNMFCAGFH EGGRDSCQGDSGGPHVTEVEGTSFL TGIISWGEECAMKGKYGIYTKVSRY VNWIKEKTKLT |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | F9 coagulation factor IX [ Homo sapiens ] |
Official Symbol : | F9 |
Synonyms : | F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component; F9 p22; FIX F9; factor 9; factor IX F9; serine protease; Christmas factor; plasma thromboplastin component; P19; PTC; HEMB; THPH8; MGC129641; MGC129642; |
Gene ID : | 2158 |
mRNA Refseq : | NM_000133 |
Protein Refseq : | NP_000124 |
MIM : | 300746 |
UniProt ID : | P00740 |
Products Types
◆ Recombinant Protein | ||
F9-2502H | Recombinant Human F9 protein(51-120 aa), C-His-tagged | +Inquiry |
F9-013H | Active Recombinant Human F9 Protein, His-tagged | +Inquiry |
F9-1838R | Recombinant Rat F9 Protein, His (Fc)-Avi-tagged | +Inquiry |
F9-915R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-1358R | Recombinant Rhesus Macaque F9 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
F9-301R | Native Rat Factor IXa | +Inquiry |
F9-26523TH | Native Human F9 | +Inquiry |
F9-671H | Native Human Coagulation Factor IX | +Inquiry |
◆ Lysates | ||
F9-1768MCL | Recombinant Mouse F9 cell lysate | +Inquiry |
F9-1849HCL | Recombinant Human F9 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe short half-life makes this product very safe.
This protein has a wide range of applications and can be used in a variety of experiments.
The method of use is simple, which reduces the experimental time and improves the efficiency.
Q&As (6)
Ask a questionThe F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.
Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.
F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.
Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.
The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).
F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.
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