Recombinant Mouse F9 protein, His-tagged
Cat.No. : | F9-7808M |
Product Overview : | Recombinant Mouse F9 aa. (Glu241~Trp463 (Accession # P16294)) fused with N-terminal His tag was produced in E. coli cells. |
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Description : | This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with factor VIII, membrane phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 26.5kDa |
Protein length : | Glu241~Trp463 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 7.2. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | F9 coagulation factor IX [ Mus musculus (house mouse) ] |
Official Symbol : | F9 |
Synonyms : | F9; coagulation factor IX; Cf9; Cf-9; AW111646; christmas factor |
Gene ID : | 14071 |
mRNA Refseq : | NM_001305797.1 |
Protein Refseq : | NP_001292726.1 |
UniProt ID : | P16294 |
Products Types
◆ Recombinant Protein | ||
F9-013H | Active Recombinant Human F9 Protein, His-tagged | +Inquiry |
F9-1358R | Recombinant Rhesus Macaque F9 Protein, His (Fc)-Avi-tagged | +Inquiry |
F9-3626H | Recombinant Human F9 Protein, GST-tagged | +Inquiry |
F9-914R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-915R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
F9-266B | Active Native Bovine Factor IX | +Inquiry |
F9-300R | Native Rat Factor IX | +Inquiry |
F9-301R | Native Rat Factor IXa | +Inquiry |
◆ Lysates | ||
F9-1849HCL | Recombinant Human F9 cell lysate | +Inquiry |
F9-1768MCL | Recombinant Mouse F9 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe short half-life makes this product very safe.
This protein has a wide range of applications and can be used in a variety of experiments.
The method of use is simple, which reduces the experimental time and improves the efficiency.
Q&As (6)
Ask a questionThe F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.
Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.
F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.
Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.
The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).
F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.
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