Active Native Bovine Factor IX
Cat.No. : | F9-266B |
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Description : | The zymogen factor IX is a single chain vitamin K-dependent glycoprotein which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 γ-carboxyglutamic acid (gla) residues which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180). Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A (see figure) yields the intermediate IXa which is subsequently converted to the fully active form IXaβ by cleavage at site B. The NH2-terminal light chain (GLA and EGF domains) remains covalently attached to the COOH-terminal heavy chain by a disulfide bond. The serine protease catalytic triad (Ser-365, His 221, Asp-269) is located in the heavy chain. Factor IXaβ is the catalytic component of the "intrinsic factor Xase complex" (factor VIIIa/IXa/Ca2+/phospholipid) which proteolytically activates factor X to factor Xa. |
Source : | Plasma |
Species : | Bovine |
Form : | 50% (vol/vol) glycerol/H2O |
Bio-activity : | Clotting assay |
Molecular Mass : | 55400 |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:12.0, Isoelectric point:3.7, Percent carbohydrate:0.26, Structure:single chain, NH2-terminal gla-domain, two EGF domains |
Storage : | -20°C |
Tag : | Non |
Gene Name : | F9 coagulation factor IX [ Bos taurus ] |
Official Symbol : | F9 |
Synonyms : | coagulation factor I; Xchristmas factor; plasma thromboplastic component; coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) |
Gene ID : | 280688 |
mRNA Refseq : | NM_001103220 |
Protein Refseq : | NP_001096690 |
Chromosome Location : | Xq32-q33 |
Pathway : | Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Extrinsic Pathway, organism-specific biosystem |
Function : | calcium ion binding; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
F9-1838R | Recombinant Rat F9 Protein, His (Fc)-Avi-tagged | +Inquiry |
F9-915R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-2502H | Recombinant Human F9 protein(51-120 aa), C-His-tagged | +Inquiry |
F9-1358R | Recombinant Rhesus Macaque F9 Protein, His (Fc)-Avi-tagged | +Inquiry |
F9-914R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
F9-300R | Native Rat Factor IX | +Inquiry |
F9-301R | Native Rat Factor IXa | +Inquiry |
F9-26523H | Active Native Human F9 Protein | +Inquiry |
◆ Lysates | ||
F9-1768MCL | Recombinant Mouse F9 cell lysate | +Inquiry |
F9-1849HCL | Recombinant Human F9 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe short half-life makes this product very safe.
This protein has a wide range of applications and can be used in a variety of experiments.
The method of use is simple, which reduces the experimental time and improves the efficiency.
Q&As (6)
Ask a questionThe F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.
Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.
F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.
Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.
The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).
F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.
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