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Recombinant Rabbit F9 Protein, His-tagged

Cat.No. : F9-914R
Product Overview : Recombinant Rabbit F9 Protein (IIe228-Lys460) with His tag was expressed in E. coli.
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Description : This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Source : E. coli
Species : Rabbit
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 29.7 kDa; Accurate Molecular Mass: 33 kDa
Protein length : IIe228-Lys460
Purity : > 80%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : F9 coagulation factor IX [ Oryctolagus cuniculus (rabbit) ]
Official Symbol : F9
Synonyms : F9; coagulation factor IX; christmas factor;
Gene ID : 100009113
mRNA Refseq : NM_001195725
Protein Refseq : NP_001182654
UniProt ID : G1U9U2

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/15/2021

    The short half-life makes this product very safe.

    10/10/2020

      This protein has a wide range of applications and can be used in a variety of experiments.

      03/27/2019

        The method of use is simple, which reduces the experimental time and improves the efficiency.

        Q&As (6)

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        What is the function of F9 protein? 12/18/2019

        The F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.

        How do genetic mutations in the F9 protein affect its function? 12/04/2019

        Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.

        Do F9 protein mutations cause other diseases or affect other physiological processes? 05/27/2019

        F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.

        What diseases can F9 gene mutations cause? 05/22/2019

        Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.

        How is the activity of F9 protein determined? 04/08/2019

        The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).

        What is the structure of F9 protein? 01/31/2019

        F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.

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