|Official Full Name||family with sequence similarity 175, member A|
|Background||Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.|
|Synonyms||FAM175A; family with sequence similarity 175, member A; ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
fam175a involved in several pathways and played different roles in them. We selected most pathways fam175a participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with fam175a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cell Cycle||CSNK1E; DCTN3; ANKLE2; E2F5; TGFB1A; TEX12; SMC1B; E2F2; ANAPC5; TINF2|
|Cell Cycle Checkpoints||MCM10; HIST4H4; THRSP; YWHAQ; RAD9A; HTATIP; CLSPN; CHEK2; TP53BP1; BARD1|
|DNA Double Strand Break Response||CHEK2; BARD1; TP53BP1; EYA4; UIMC1; FAM175A; KDM4B; SMARCA5; BRE; THRSP|
|DNA Double-Strand Break Repair||PPP4CB; UIMC1; HTATIP; FAM175A; RAD17; TIPIN; PPP4R2A; KIAA0146; DNA2; RAD9A|
|DNA Repair||PPP4R2; DCLRE1A; ERCC8; PPP4CB; GEN1; UBE2V2; BRE; CHEK2; PPP4CA; EME2|
|G2/M Checkpoints||RAD1; RAD17; BARD1; UIMC1; BRCC3; BRE; RAD9A; FAM175A; TP53BP1; BABAM1|
|G2/M DNA damage checkpoint||FAM175A; RNF168; TP53BP1; BABAM1; BRE; UIMC1; BARD1; BRCC3; THRSP|
|HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)||RNF4; EME2; WRN; UIMC1; PPP4R2; FAM175A; FUZ; BRCC3; BRE; RAD9B|
fam175a has several biochemical functions, for example, polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fam175a itself. We selected most functions fam175a had, and list some proteins which have the same functions with fam175a. You can find most of the proteins on our site.
|polyubiquitin binding||UBQLN1; DZIP3; THRSP; UBQLN4; PSMD4A; BAG6; BRCC3; FAM175A; UBXN1; PSMD4B|
fam175a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fam175a here. Most of them are supplied by our site. Hope this information will be useful for your research of fam175a.