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FAM175A

Official Full Name

family with sequence similarity 175, member A
Overview

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Synonyms

FAM175A; family with sequence similarity 175, member A; ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Mouse
Rat
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	FAM175A-5536M	Recombinant Mouse FAM175A Protein	Mammalian Cell	His	Inquiry
Mouse	FAM175A-3016M	Recombinant Mouse FAM175A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	FAM175A-3016M-B	Recombinant Mouse FAM175A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	FAM175A-2227R	Recombinant Rat FAM175A Protein	Mammalian Cell	His	Inquiry
Rat	FAM175A-1884R	Recombinant Rat FAM175A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	FAM175A-1884R-B	Recombinant Rat FAM175A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	FAM175A-1517Z	Recombinant Zebrafish FAM175A	Mammalian Cell	His	Inquiry
Chicken	FAM175A-2816C	Recombinant Chicken FAM175A	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
FAM175A Related Articles

FAM175A involved in several pathways and played different roles in them. We selected most pathways FAM175A participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAM175A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	CDKN2C;SYCP2;GADD45AA;NDE1;ANAPC2;ANAPC11;DYRK1A;DHFR;CSNK2B
Cell Cycle Checkpoints	TP53BP1;BRCC3;UIMC1;RNF168;BRE;CDK2;RAD9A;FAM175A;MCM8
DNA Double Strand Break Response	BRE;BARD1;BRCC3;EYA3;KDM4B;BAZ1B;EYA2;THRSP;BABAM1
DNA Double-Strand Break Repair	RBBP8;RTEL1;TIMELESS;RHNO1;RAD9B;PARP2;EYA2;UIMC1;EME1
DNA Repair	ELL;UBE2L6;PAXIP1;PNKP;USP45;COPS7A;MGMT;COPS4;INO80E
G2/M Checkpoints	RAD9A;BRCC3;THRSP;TP53BP1;HUS1;BARD1;BABAM1;RNF168;UIMC1
G2/M DNA damage checkpoint	FAM175A;UIMC1;BARD1;TP53BP1;BRE;RNF168;BABAM1;THRSP;BRCC3
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	GEN1;FUZ;UIMC1;RNF168;RAD9B;RAD9;TIMELESS;KIAA0146;BABAM1

FAM175A has several biochemical functions, for example, polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAM175A itself. We selected most functions FAM175A had, and list some proteins which have the same functions with FAM175A. You can find most of the proteins on our site.

Function	Related Protein
polyubiquitin binding	DZIP3;AGL;UBXN1;VCP;HDAC6;RAD23A;TNIP2;ZFAND6;BRE

FAM175A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAM175A here. Most of them are supplied by our site. Hope this information will be useful for your research of FAM175A.

Carpena, X; Switala, J; et al. Crystallization and preliminary X-ray analysis of the catalase-peroxidase KatG from Burkholderia pseudomallei. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58:2184-2186(2002).

Park, H; Kim, SI; et al. Characterization and classification of five cysteine proteinases expressed by Paragonimus westermani adult worm. EXPERIMENTAL PARASITOLOGY 102:143-149(2002).