FANCA
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Official Full Name
Fanconi anemia, complementation group A
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Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. -
Synonyms
FANCA; Fanconi anemia, complementation group A; FACA, FANCH; Fanconi anemia group A protein; FA H; FAA; FAH; Fanconi anemia, type 1; Fanconi anemia, complementation group H; FA; FA1; FA-H; FACA; FANCH; MGC75158;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | FANCA-6929H | Recombinant Human FANCA, His tagged | Insect Cell | His | Met 1-Cys 297 |
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| Human | FANCA-3825H | Recombinant Human FANCA Protein, GST-tagged | Wheat Germ | GST |
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| Human | FANCA-499HCL | Recombinant Human FANCA cell lysate | Insect Cell | N/A |
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| Human | FANCA-4662HF | Recombinant Full Length Human FANCA Protein, GST-tagged | In Vitro Cell Free System | GST | 297 amino acids |
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| Mouse | FANCA-5667M | Recombinant Mouse FANCA Protein | Mammalian Cell | His |
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| Mouse | FANCA-3110M | Recombinant Mouse FANCA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | FANCA-3110M-B | Recombinant Mouse FANCA Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | FANCA-3811Z | Recombinant Zebrafish FANCA | Mammalian Cell | His |
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| Chicken | FANCA-3863C | Recombinant Chicken FANCA | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- FANCA Related Articles
- FANCA Related Research Area
FANCA involved in several pathways and played different roles in them. We selected most pathways FANCA participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi anemia pathway | FANCG;RPA2;APITD1;STRA13;EME2;USP1;UBE2T;SLX1B;BLM |
FANCA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCA itself. We selected most functions FANCA had, and list some proteins which have the same functions with FANCA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MSH6;UBTD1;PRDM14;CENPH;HNRNPAB;Car4;CD200R1;KIAA1143;FERD3L |
FANCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCA here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCA.
FANCG; BRCA1; FANCC; FANCF
- Q&As
- Reviews
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