FBLN1

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FBLN1

Official Full Name fibulin 1
Background Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
Synonyms FBLN1; fibulin 1; fibulin-1; FBLN; Basement membrane protein 90; BM 90; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; OTTHUMP00000199864; OTTHUMP00000199865; OTTHUMP00000199866; OTTHUMP00000199867; OTTHUMP00000214005
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • MYC/DDK
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FBLN1-12764H Recombinant Human FBLN1, GST-tagged E.coli GST
    Human FBLN1-16H Recombinant Human FBLN1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human FBLN1-2429H Recombinant Human FBLN1 Protein (30-703 aa), His-Myc-tagged Yeast His/Myc
    Human FBLN1-28901TH Recombinant Human FBLN1 Wheat Germ N/A
    Human FBLN1-28904TH Recombinant Human FBLN1 Wheat Germ N/A
    Human FBLN1-3872H Recombinant Human FBLN1 Protein, GST-tagged Wheat Germ GST
    Human FBLN1-598HCL Recombinant Human FBLN1 cell lysate N/A
    Human FBLN1-6144H Recombinant Human FBLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FBLN1-723H Recombinant Human FBLN1 Protein, His-tagged E.coli His
    Mouse Fbln1-1023M Recombinant Mouse Fbln1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Fbln1-724M Recombinant Mouse Fbln1 Protein, His-tagged E.coli His
    Rat Fbln1-725R Recombinant Rat Fbln1 Protein, His-tagged E.coli His
    Rat Fbln1-726R Recombinant Rat Fbln1 Protein, His/GST-tagged E.coli His/GST
    Chicken FBLN1-5740C Recombinant Chicken FBLN1 Mammalian Cell His
    Zebrafish FBLN1-8670Z Recombinant Zebrafish FBLN1 Mammalian Cell His

    FBLN1 involved in several pathways and played different roles in them. We selected most pathways FBLN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Elastic fibre formation LOX; FBN1; LOXL2; EFEMP2; LTBP4; FBN2; BMP10; EFEMP1; FURINA; LOXL1
    Extracellular matrix organization MATN4; FMOD; LEPRE1; COL6A2; LEPREL1; LRP4; PCOLCE2; COL25A1; ADAMTS1; COL5A1
    Molecules associated with elastic fibres FBLN2; BMP10; MFAP3; EFEMP1; MFAP4; FBLN1; LTBP2; MFAP5; LTBP3; MFAP1

    FBLN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN1 itself. We selected most functions FBLN1 had, and list some proteins which have the same functions with FBLN1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding SGCA; DOC2B; ANXA1; SYT3; PCDHGC3; PCDH15A; SVEP1; PCDH8; EMR4; SLC24A4
    extracellular matrix structural constituent COL11A1B; COL27A1B; COL5A1; COMP; IMPG2; CD4; IMPG1; KAL1; FBN1; COL4A3
    fibrinogen binding THBS1; ITGA2B; MFAP2; FBLN1
    fibronectin binding SDC4; THBS1; FBLN1; SFRP2; MMP13; ITGA3; ITGB1; IGFBP5B; LRRC15; CCDC80
    identical protein binding RUNX1T1; DPP9; ACTN2; GRB2; PACSIN2; NQO1; SH2B2; NFKB1; PLEKHH2; SIAH1A
    integrin binding LYN; FERMT3; ITGA6; DMP1; AMICA1; ADAM2; TLN1; ACTN2; ICAM3; ITGB6
    peptidase activator activity PSME4B; MMP25; APP; FBLN1; PCOLCE2; MMP14; FN1; CAV1; PSME4; PCOLCE
    protein C-terminus binding ERBB2; ITGB3BP; ABL1; CEP135; ITPR1; HRAS; CDC20; LIG4; TBL1X; VGLL2
    protein binding RSU1; NRP1; STMN2; TOR1A; TXNDC5; PRLHR; IL1RAPL1; DAO; ELAVL1; RPL9
    protein complex binding KAT2B; KIF11; RXRA; TAB1; MLKL; EP300; AP2B1; ANKRD32; BAX; UGT1A6B

    FBLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN1.

    APOA1; SMAD3; YWHAQ; MPG; Tubb4b; CACNA1A; BHLHE40; PLSCR1; FN1; TFAP2A; SKIL; TDGF1; ATN1; SMAD4; GFI1B; EDC4

    Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
    Long, KB; Artlett, CM; et al. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. MATRIX BIOLOGY 38:91-100(2014).

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