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FBXL14

Official Full Name

F-box and leucine-rich repeat protein 14
Overview

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif.;SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as;protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination;targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).
Synonyms

FBXL14; F-box and leucine-rich repeat protein 14; F-box/LRR-repeat protein 14; Fbl14; MGC40195;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXL14-3890H	Recombinant Human FBXL14 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXL14-12772H	Recombinant Human FBXL14, His-tagged	E.coli	His	1-418a.a.	$319 / 25ug
Human	FBXL14-271HCL	Recombinant Human FBXL14 lysate	HEK293	N/A		Inquiry
Human	FBXL14-4945HF	Recombinant Full Length Human FBXL14 Protein, GST-tagged	In Vitro Cell Free System	GST	418 amino acids	Inquiry
Mouse	FBXL14-5713M	Recombinant Mouse FBXL14 Protein	Mammalian Cell	His		Inquiry
Mouse	FBXL14-3140M	Recombinant Mouse FBXL14 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FBXL14-3140M-B	Recombinant Mouse FBXL14 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	FBXL14-1652R	Recombinant Rhesus monkey FBXL14 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FBXL14-1476R-B	Recombinant Rhesus Macaque FBXL14 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	FBXL14-1476R	Recombinant Rhesus Macaque FBXL14 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXL14 Related Articles

FBXL14 involved in several pathways and played different roles in them. We selected most pathways FBXL14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FBXL14 has several biochemical functions, for example, protein binding, contributes_to ubiquitin protein ligase activity, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL14 itself. We selected most functions FBXL14 had, and list some proteins which have the same functions with FBXL14. You can find most of the proteins on our site.

Function	Related Protein
protein binding	APOBEC3F;TARBP2;UBE3A;DNMT3A;Kitl;PALM;GIPC1;STAT5B;EIF1AD
contributes_to ubiquitin protein ligase activity	CUL4A;CUL2;CUL3;C10orf46;CUL1B;CUL1;CUL1A;FBXL7;FBXL22
ubiquitin-protein transferase activity	FBXO40.1;RNF43;TRIM68;RNF115;RNF146;BIRC5;BRAP;RNF152;BIRC7

FBXL14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL14 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL14.

b4dyc6_human; SNAI1; HSP90AB1; FKBP5; HSP90AB1; Hacd3; AARSD1

Silva, IMW; Rosenfeld, J; et al. A 1.5 Mb terminal deletion of 12p associated with autism spectrum disorder. GENE 542:83-86(2014).

Vinas-Castells, R; Frias, A; et al. Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. NUCLEIC ACIDS RESEARCH 42:1079-1094(2014).