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FBXW2

  • Official Full Name

    F-box and WD repeat domain containing 2

  • Overview

    F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
  • Synonyms

    FBXW2; F-box and WD repeat domain containing 2; F box and WD 40 domain protein 2; F-box/WD repeat-containing protein 2; FBW2; Fwd2; Md6; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; MGC117371;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBXW2-12810H Recombinant Human FBXW2, GST-tagged E.coli GST N-term-314a.a.
Human FBXW2-3970H Recombinant Human FBXW2 Protein, GST-tagged Wheat Germ GST
Human FBXW2-6285HCL Recombinant Human FBXW2 293 Cell Lysate HEK293 N/A
Human FBXW2-4702HF Recombinant Full Length Human FBXW2 Protein, GST-tagged In Vitro Cell Free System GST 454 amino acids
Rat FBXW2-2302R Recombinant Rat FBXW2 Protein Mammalian Cell His
Rat FBXW2-1959R Recombinant Rat FBXW2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FBXW2-1959R-B Recombinant Rat FBXW2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FBXW2-2668Z Recombinant Zebrafish FBXW2 Mammalian Cell His
Chicken FBXW2-1767C Recombinant Chicken FBXW2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FBXW2 involved in several pathways and played different roles in them. We selected most pathways FBXW2 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Association of TriC/CCT with target proteins during biosynthesisCCT5;FBXW5;CCT3;CCT8;FBXL5;FBXW4;CCT4;FBXW9;KIFC3
Chaperonin-mediated protein foldingCCT2;FBXW4;FBXW5;CCT7;CCT4;CCT8;FKBP9;KIFC3;CCT5
Metabolism of proteinsGALNTL5;YKT6;PFDN2;MUC20;SLC30A8;CNIH;CST3;ADAMTS1;DPH5
Protein foldingFBXW9;FBXW5;PFDN1;TBCD;PFDN5;ARL2;CCT7;TBCA;PFDN4
Wnt Signaling PathwaySIAH2L;WNT7A;TRP53;CAMK2G1;FZD2;GPC4;SIAH1A;FZD8B;BAMBIB
Wnt Signaling Pathway and PluripotencyFBXW2;LRRK2;FOXD3;PPM1J;ZBTB33

FBXW2 has several biochemical functions, for example, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW2 itself. We selected most functions FBXW2 had, and list some proteins which have the same functions with FBXW2. You can find most of the proteins on our site.

Function Related Protein
protein bindingSTAT3;RPLP0;TMEM119;UBE2D3;PTPRD;FATE1;TMEM86B;ZDHHC17;TRP63
ubiquitin-protein transferase activityUBE2G2;ANKIB1;UBE3C;UBE2L3;MIB2;TRIM62;TRAF4B;BRCA1;UBE2H

FBXW2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW2.

SKP1; CUL1; CDC37; HSP90AB1; SKP1; NUDC; b4dyc6_human; HSP90AA1; STIP1; q53fc7_human; HSP90AB1; NUDCD2; PPP5C

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