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FLIP

  • Official Full Name

    FLIP α (C-terminus)

  • Overview

    Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed α, β, γ, δ, respectively.
  • Synonyms

    FLIP; c FLIPL; c FLIPR; c FLIPS; c-FLIP; CASH; CASP8 and FADD like apoptosis regulator; CASP8 and FADD like apoptosis regulator precursor; CASP8 and FADD-like apoptosis regulator subunit p12; CASP8; CASP8AP1; Caspase Eight Related Protein antibody; Caspas;

  • Recombinant Proteins
  • Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
  • Aquifex aeolicus (strain VF5)
  • Bacillus subtilis
  • Bacillus subtilis (strain 168)
  • Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
  • Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
  • Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
  • Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
  • Caulobacter crescentus (strain ATCC 19089 / CB15)
  • Escherichia coli (strain K12)
  • Escherichia coli O157:H7
  • Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
  • Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
  • Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
  • Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
  • Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
  • Treponema pallidum (strain Nichols)
  • E. coli or Yeast
  • E.coli expression system
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) RFL5420AF Recombinant Full Length Agrobacterium Tumefaciens Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-245)
Aquifex aeolicus (strain VF5) RFL34017AF Recombinant Full Length Aquifex Aeolicus Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-239)
Bacillus subtilis FLIP-1585B Recombinant Bacillus subtilis FLIP protein, His-tagged E. coli or Yeast His
Bacillus subtilis (strain 168) RFL20469BF Recombinant Full Length Bacillus Subtilis Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-221)
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) RFL21626BF Recombinant Full Length Borrelia Burgdorferi Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-254)
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) RFL35823BF Recombinant Full Length Buchnera Aphidicola Subsp. Acyrthosiphon Pisum Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-379)
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) RFL15747BF Recombinant Full Length Buchnera Aphidicola Subsp. Baizongia Pistaciae Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) RFL19284BF Recombinant Full Length Buchnera Aphidicola Subsp. Schizaphis Graminum Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-379)
Caulobacter crescentus (strain ATCC 19089 / CB15) RFL27778CF Recombinant Full Length Caulobacter Crescentus Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-266)
Escherichia coli (strain K12) RFL5123EF Recombinant Full Length Escherichia Coli Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-245)
Escherichia coli O157:H7 RFL30352EF Recombinant Full Length Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-245)
Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora) RFL4437PF Recombinant Full Length Pectobacterium Carotovorum Subsp. Carotovorum Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-258)
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) RFL26190PF Recombinant Full Length Pseudomonas Aeruginosa Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-255)
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) RFL3787RF Recombinant Full Length Rhizobium Meliloti Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-245)
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) RFL1931RF Recombinant Full Length Rhodobacter Sphaeroides Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-301)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) RFL32461SF Recombinant Full Length Salmonella Typhimurium Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-245)
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) RFL9558TF Recombinant Full Length Treponema Denticola Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Treponema pallidum (strain Nichols) RFL34831TF Recombinant Full Length Treponema Pallidum Flagellar Biosynthetic Protein Flip(Flip) Protein, His-Tagged E.coli expression system His Full Length (1-271)
  • FLIP Related Research Area

FLIP involved in several pathways and played different roles in them. We selected most pathways FLIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FLIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

FLIP has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FLIP itself. We selected most functions FLIP had, and list some proteins which have the same functions with FLIP. You can find most of the proteins on our site.

Function Related Protein

FLIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLIP here. Most of them are supplied by our site. Hope this information will be useful for your research of FLIP.

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