FOXH1

  • Official Full Name

    forkhead box H1
  • Overview

    Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.
  • Synonyms

    FOXH1;forkhead box H1;forkhead box protein H1;FAST 1;Fast 2;Fast-1;Fast-2;FAST1;Fast2;Forkhead activin signal transducer 1;Forkhead activin signal transducer 2;FOX H1;FOXH 1;FOXH1_HUMAN;hFAST 1;hFAST-1;hFAST1;Human homolog of Xenopus forkhead activin signal transducer 1;TGF beta/Activin signal transducer FAST1
Cat.# Product name Source (Host) Species Tag Protein Length Price
FOXH1-5991M Recombinant Mouse FOXH1 Protein Mammalian Cells Mouse His
FOXH1-9052Z Recombinant Zebrafish FOXH1 Mammalian Cells Zebrafish His
FOXH1-6156HCL Recombinant Human FOXH1 293 Cell Lysate HEK293 Human Non
FOXH1-2562H Recombinant Human FOXH1 Protein, His-tagged E.coli Human His
FOXH1-3324M Recombinant Mouse FOXH1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FOXH1-3324M-B Recombinant Mouse FOXH1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    FOXH1 involved in several pathways and played different roles in them. We selected most pathways FOXH1 participated on our site, such as Developmental Biology,Heart Development,Regulation of nuclear SMAD2/3 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta Receptor Signaling Pathway ZEB2A,STK11IP,SKIA,CTCF,ENG,TRAP1,NFYBB,JUNBA,HOXD9A,SNIP1
    Heart Development NKX2-5,IRX4,FOXC1,GATA6,SMYD1,HEY1,BMP10,FOXC2,HEY2,TBX20
    Developmental Biology JAK3,SEMA4D,CFL1,TCF4,DUSP1,NRP2,MED20,SREBF2,INSM1A,NRTN
    Regulation of nuclear SMAD2/3 signaling SKI,NKX2,SNIP1,MYOD1,CBFB,GSC,CITED1
    TGF Beta Signaling Pathway NOG,LEFTY1,ZNF423,TGFBR3,ENG,ZFP423,RUNX3,FST
    Signaling by NODAL DRAP1,PCSK6,ACVR1C,CFC1,TDGF1,LEFTY1,GDF1
    Signal Transduction RBP3,FGFBP1,ARHGAP9,RTKN,FMNL1,RGS7,GPR31,OR56A1,GPR55,WIPF2
    Signaling by Activin FST,FSTL3,FSTB,ACVR1C,DRAP1,INHBAA

    Protein Function

    FOXH1 has several biochemical functions, for example, contributes_to DNA binding,R-SMAD binding,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXH1 itself. We selected most functions FOXH1 had, and list some proteins which have the same functions with FOXH1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity MED13L,MED18,MED13A,MED10,MED13,MED31,MED17,MED13B,MED15,MED22
    androgen receptor binding BRCA1,NRIP1,PRMT2,CALR,RAN,CDK7,NCOA1,EP300,PRKCBB,KAT5
    contributes_to transcription factor activity, sequence-specific DNA binding TAF6,SOX1B,NKX2-5,SOX19A,TRIM28,RXRA,SMAD2,NKX2,TAF10,VDRB
    transcription regulatory region DNA binding DLX5,ATMIN,SP1,JUND,TAF7,ZNF567,SMAD6,HOXA13,WNT1,ZNF649
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding POU4F1,PBX3,HOXB5,PROP1,BACH1,SPI1,SIX6,MEOX2,NFE2L1,MIXL1
    SMAD binding PURB,SKI,SKIL,RNF111,PURA,COL3A1,SMURF2,SKIB,TGFBR2,EP300
    contributes_to DNA binding AHR2,GTF3C5,ARNTL1B,GTF3C4,SMAD4,MLXIPL,MCM7,MAFGB,TCF3,MRE11A
    transcription factor activity, sequence-specific DNA binding ARNTL1A,ZFHX3,NFATC1,HES6,TTC4,PRDM1A,EGR3,DMRTA1,NR4A2A,SUPT4H1
    protein domain specific binding TACC2,YWHABA,XPO1,CALM,BASP1,WNT3,ARFIP2,STXBP1,RAB27A,RXRA

    Interacting Protein

    FOXH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXH1.

    AR;fbe;TCF3;NCK1;PIK3R1;GRB2;SMAD3;SMAD2;TCF12

    Resources

    References

    • Chiu, WT; Le, RC; et al. Genome-wide view of TGF beta/Foxh1 regulation of the early mesendoderm program. DEVELOPMENT 141:4537-4547(2014).
    • Nelson, AC; Cutty, SJ; et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC BIOLOGY 12:-(2014).

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