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FOXH1

Official Full Name

forkhead box H1
Overview

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.
Synonyms

FOXH1; forkhead box H1; forkhead box protein H1; FAST 1; Fast 2; Fast-1; Fast-2; FAST1; Fast2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; FOX H1; FOXH 1; FOXH1_HUMAN; hFAST 1; hFAST-1; hFAST1; Human homolog of Xenopus forkhead activin signal transducer 1; TGF beta/Activin signal transducer FAST1;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	FOXH1-6156HCL	Recombinant Human FOXH1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	FOXH1-2562H	Recombinant Human FOXH1 Protein, His-tagged	E.coli	His	Inquiry
Mouse	FOXH1-5991M	Recombinant Mouse FOXH1 Protein	Mammalian Cell	His	Inquiry
Mouse	FOXH1-3324M-B	Recombinant Mouse FOXH1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	FOXH1-3324M	Recombinant Mouse FOXH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	FOXH1-9052Z	Recombinant Zebrafish FOXH1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
FOXH1 Related Articles

FOXH1 involved in several pathways and played different roles in them. We selected most pathways FOXH1 participated on our site, such as Developmental Biology, Heart Development, Regulation of nuclear SMAD2/3 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Developmental Biology	EPHA2;TRPC3;NR2F2;PEA15A;FGFR1B;DRAP1;KIF4A;CAP1;EPHB3A
Heart Development	HEY2;HEY1;GATA6;SMYD1;BMP10;FOXH1;IRX4;NKX2;TBX5
Regulation of nuclear SMAD2/3 signaling	GSC;CBFB;CITED1;SKI;SNIP1;MYOD1;FOXH1;NKX2
Signal Transduction	TLE2;GPR77;QRFPR;IFT52;SHARPIN;ARHGEF25;ADM;FGD4A;EDNRAB
Signaling by Activin	ACVR1C;FOXH1;FSTL3;FST;INHBAA;DRAP1;FSTB
Signaling by NODAL	CFC1;LEFTY1;TDGF1;GDF1;FOXH1;DRAP1;ACVR1C;PCSK6
TGF Beta Signaling Pathway	TGFBR3;FST;LEFTY1;ENG;RUNX3;NOG;ZNF423;ZFP423;FOXH1
TGF-beta Receptor Signaling Pathway	TGFBR3;VDRB;ENG;GIPC1;EID2;CITED1;COPS5;MEF2AA;ZEB1B

FOXH1 has several biochemical functions, for example, contributes_to DNA binding, R-SMAD binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXH1 itself. We selected most functions FOXH1 had, and list some proteins which have the same functions with FOXH1. You can find most of the proteins on our site.

Function	Related Protein
contributes_to DNA binding	FOXH1;MAFGA;ARNTL1A;GTF3C5;ARNTL1B;NFE2L2A;MCM7;RFC3;MRE11A
R-SMAD binding	PPM1A;ZEB2;FOXH1;PMEPA1;SMURF1;AXIN1;TRIM33;RANBP3;PARP1
RNA polymerase II transcription cofactor activity	MED4;MED9;MED19;RBM14;NKX2;MED11;MED13L;MED18;MED19A
RNA polymerase II transcription factor activity, sequence-specific DNA binding	NHLH2;FOXD2;ZNF202;FEV;SPI1;EOMESA;ERG;FOXK1;TFDP1B
SMAD binding	PRDM16;SKIL;SKOR1B;SOD3;PURB;MAGI2;SKOR1;BMP2;EP300
androgen receptor binding	PRKCB;NCOA3;NCOA1;NRIP1;DAXX;RNF6;PRMT2;PKN1;SMARCA4
bHLH transcription factor binding	TCF3;ASCL1;PSMD9;SIRT1;USF2;FOXH1;LMO2;USF1;TCF3B
co-SMAD binding	FOXH1;SMAD1;TRIM33;SMAD6;CITED1;SMAD3;GATA4;TGIF1;USP9X
enhancer binding	TCF3;TIPARP;LEF1;MESP1;ARNT;FOXH1;SMAD2;SP1;AHR
protein binding	SPTSSB;VPS41;ACTL6A;PBK;FRAG1;HNRNPAB;TMEM106C;KPNA2;PACS1
protein domain specific binding	CHMP1A;ARFIP1;MYO1D;WNT5A;WHRN;PPARA;CACNB2;HOXB1;FOXA3
sequence-specific DNA binding	MAFGB;OSR2;MIXL1;POU1F1;HOXC4A;FOXA3;HOXC1A;NFYB;CENPB
contributes_to transcription factor activity, sequence-specific DNA binding	TRIM28;SMAD3;SOX1A;FOXH1;NKX2-5;SOX19B;NFE2L2A;VDR;HNRNPAB
transcription factor activity, sequence-specific DNA binding	NR2F5;GATA3;SP3A;RXRBB;STAT1A;ATF1;CITED2;RERE;FOXE3
transcription regulatory region DNA binding	SALL2;SOX2;AIRE;SMAD4;XRCC6;FOXA1;ZFP821;TCF7L1B;WNT11
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	NFATC1;CDX1;HMGA1;SFPI1;PBX3;ARID3B;SIX3;SPI1;NFKB1
transcriptional activator activity, RNA polymerase II transcription factor binding	CLOCK;NR1H4;KLF14;NKX2;JUN;MIXL1;WWP2;LMO2;SOX10

FOXH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXH1.

AR; fbe; TCF3; NCK1; PIK3R1; GRB2; SMAD3; SMAD2; TCF12

Chiu, WT; Le, RC; et al. Genome-wide view of TGF beta/Foxh1 regulation of the early mesendoderm program. DEVELOPMENT 141:4537-4547(2014).

Nelson, AC; Cutty, SJ; et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC BIOLOGY 12:-(2014).