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FRMD3

Official Full Name

FERM domain containing 3
Overview

The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms

FRMD3; FERM domain containing 3; FERM domain-containing protein 3; EPB41L4O; MGC20553; 4.1O; Band 4.1 like protein 4O; FERM domain containing protein 3; Ovary type protein 4.1; P410; protein 4.1O; band 4.1-like protein 4; band 4.1-like protein 4O; EPB41LO; RP11-439K3.2;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Source

E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FRMD3-668HCL	Recombinant Human FRMD3 cell lysate		N/A		Inquiry
Human	FRMD3-5152HF	Recombinant Full Length Human FRMD3 Protein, GST-tagged	In Vitro Cell Free System	GST	581 amino acids	Inquiry
Human	FRMD3-4499H	Recombinant Human FRMD3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	FRMD3-6037M	Recombinant Mouse FRMD3 Protein	Mammalian Cell	His		Inquiry
Mouse	FRMD3-3358M-B	Recombinant Mouse FRMD3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	FRMD3-3358M	Recombinant Mouse FRMD3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Homo sapiens (Human)	RFL9158HF	Recombinant Full Length Human Ferm Domain-Containing Protein 3(Frmd3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-597)	Inquiry
Mus musculus (Mouse)	RFL16173MF	Recombinant Full Length Mouse Ferm Domain-Containing Protein 3(Frmd3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-595)	Inquiry
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	RFL3676PF	Recombinant Full Length Pongo Abelii Ferm Domain-Containing Protein 3(Frmd3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-597)	Inquiry
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	RFL3287XF	Recombinant Full Length Xenopus Tropicalis Ferm Domain-Containing Protein 3(Frmd3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-600)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
FRMD3 Related Articles
FRMD3 Related Signal Pathway

FRMD3 involved in several pathways and played different roles in them. We selected most pathways FRMD3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FRMD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FRMD3 has several biochemical functions, for example, cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FRMD3 itself. We selected most functions FRMD3 had, and list some proteins which have the same functions with FRMD3. You can find most of the proteins on our site.

Function	Related Protein
cytoskeletal protein binding	EPB41L3B;EPB41L4A;ALDOB;MSNA;NEBL;PTPN3;LIN7C;PTPN4A;SLC8A1

FRMD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRMD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FRMD3.

q8xaj5_eco57; ATP5D; ATP5O; OXA1L

Alkayyali, S; Lyssenko, V; et al. Genetics of diabetes complications. MAMMALIAN GENOME 25:384-400(2014).

Palmer, ND; Ng, MCY; et al. Evaluation of Candidate Nephropathy Susceptibility Genes in a Genome-Wide Association Study of African American Diabetic Kidney Disease. PLOS ONE 9:-(2014).