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FUCA1

  • Official Full Name

    fucosidase, alpha-L- 1, tissue

  • Overview

    The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.
  • Synonyms

    FUCA1; fucosidase, alpha-L- 1, tissue; tissue alpha-L-fucosidase; Alpha L fucosidase I; Alpha L fucoside fucohydrolase; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; FUCA; FUCO_HUMAN; Tissue alpha L fucosidase; OTTHUMP00000003009;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc|His
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • His|T8
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FUCA1-471H Active Recombinant Human Fucosidase, Alpha-L- 1, Tissue, His-tagged Mammalian cells His
Human FUCA1-53H Recombinant Human FUCA1 protein, His-tagged Insect Cell His
Human FUCA1-13031H Recombinant Human FUCA1, GST-tagged E.coli GST 113-461a.a.
Human FUCA1-8618H Recombinant Human FUCA1, His tagged Human Cell Fc/His
Human FUCA1-7730H Recombinant Human FUCA1 protein, His & T7-tagged E.coli His/T7 Phe53~Pro289 (Accession # P04066)
Human FUCA1-28956TH Recombinant Human FUCA1 Wheat Germ N/A 100 amino acids
Human FUCA1-1134H Recombinant Human FUCA1 Mammalian Cell His
Human FUCA1-1212HCL Recombinant Human FUCA1 cell lysate Human Cell N/A
Human FUCA1-2324H Recombinant Human FUCA1 Protein (Phe53-Pro289), N-His tagged E.coli N-His Phe53-Pro289
Human FUCA1-4543H Recombinant Human FUCA1 Protein, GST-tagged Wheat Germ GST
Human FUCA1-2661H Recombinant Human FUCA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FUCA1-3572H Recombinant Human FUCA1 protein, His-tagged E.coli His 113-461 aa
Human FUCA1-5133HF Recombinant Full Length Human FUCA1 Protein, GST-tagged In Vitro Cell Free System GST 23-461 amino acids
Human FUCA1-1835H Recombinant Human FUCA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FUCA1-2356H Recombinant Human FUCA1 protein, His-tagged HEK293 His Gln32-Lys466
Human FUCA1-2983H Recombinant Human FUCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FUCA1-2983H-B Recombinant Human FUCA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse FUCA1-1217M Recombinant Mouse FUCA1 Protein, His-SUMO-tagged E.coli His/SUMO
Mouse Fuca1-7731M Recombinant Mouse Fuca1 protein, His & T8-tagged E.coli His/T8 Asn185~Lys447 (Accession # Q99LJ1)
Mouse FUCA1-6081M Recombinant Mouse FUCA1 Protein Mammalian Cell His
Mouse Fuca1-3104M Recombinant Mouse Fuca1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FUCA1-3386M-B Recombinant Mouse FUCA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse FUCA1-3386M Recombinant Mouse FUCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FUCA1-2407R Recombinant Rat FUCA1 Protein Mammalian Cell His
Rat Fuca1-7732R Recombinant Rat Fuca1 protein, His & T7-tagged E.coli His/T7 Lys170~Leu420 (Accession # P17164)
Rat FUCA1-2063R Recombinant Rat FUCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FUCA1-2063R-B Recombinant Rat FUCA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FUCA1 Related Research Area

FUCA1 involved in several pathways and played different roles in them. We selected most pathways FUCA1 participated on our site, such as Other glycan degradation, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Other glycan degradationHEXDC;NEU2;HEXA;MANBA;NEU3.2;GLB1;AGA;FUCA1;NEU4
LysosomeATP6AP1;ATP6V0A1A;ATP6V0C;FAM49BA;ACP2;ACP5;LGMN;PSAPL1;MFSD8

FUCA1 has several biochemical functions, for example, alpha-L-fucosidase activity, fucose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUCA1 itself. We selected most functions FUCA1 had, and list some proteins which have the same functions with FUCA1. You can find most of the proteins on our site.

Function Related Protein
alpha-L-fucosidase activityFUCA1.1;FUCA1.2;FUCA2;FUCA1
fucose bindingFUCA2;FUCA1;SELP;FUOM

FUCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUCA1.

MARK2; USP21; VAV2

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do genetic variations in FUCA1 affect its enzymatic activity? 12/10/2022

Genetic mutations in FUCA1 can lead to deficient enzyme activity, affecting glycan metabolism.

What is the impact of altered FUCA1 activity on lysosomal storage diseases? 02/27/2022

Altered FUCA1 activity is associated with lysosomal storage diseases, such as fucosidosis, due to the accumulation of undigested glycans.

What is the primary role of FUCA1 in cellular metabolism? 02/28/2021

FUCA1, an alpha-L-fucosidase, is involved in the breakdown of complex sugars (glycans) in cellular metabolism.

What role does FUCA1 play in lysosomal function? 10/22/2020

FUCA1 is crucial for normal lysosomal function, aiding in the breakdown of glycoproteins and glycolipids.

How does FUCA1 contribute to glycan breakdown? 08/26/2018

It helps in glycan degradation by cleaving fucose residues, a key step in glycan processing.

How does FUCA1 interact with other enzymes in glycan metabolism? 06/27/2018

FUCA1 works alongside other enzymes in glycan metabolism, ensuring efficient breakdown and recycling of cellular components.

What potential therapeutic applications arise from targeting FUCA1 in metabolic disorders? 06/05/2017

Targeting FUCA1 could offer therapeutic strategies for treating lysosomal storage disorders and related metabolic conditions.

Customer Reviews (3)

Write a review
Reviews
08/16/2021

    Precise results, a trusted partner in our experiments.

    05/11/2020

      Dependable service, vital for accurate protein analysis.

      09/12/2019

        Efficient support, accelerates our research progress.

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