FUS
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Official Full Name
fused in sarcoma
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Overview
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] -
Synonyms
FUS; fused in sarcoma; TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2; RNA-binding protein FUS; oncogene FUS; oncogene TLS; fus-like protein; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; heterogeneous nuclear ribonucleoprotein P2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- C
- MBP
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
FUS involved in several pathways and played different roles in them. We selected most pathways FUS participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | ATF1;CCNT2;CD14;NGFR;TLX3;SSX1;SSX2;REL;MEF2C |
FUS has several biochemical functions, for example, DNA binding, RNA binding, estrogen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUS itself. We selected most functions FUS had, and list some proteins which have the same functions with FUS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RUNX2A;IRX7;FOXF2;SSH1;SIX6;BBX;TCF7L1A;SRFA;ZNF280C |
| RNA binding | SF3A1;RPS5;NHP2L1A;SAMHD1;AGO3B;RPP14;RPL30;APOBEC2;RPL3 |
| estrogen receptor binding | PPARGC1B;DDX17;STRN;PHB2;NKX3;WIPI1;HSD17B10;CTNNB1;PPID |
| identical protein binding | HOMER1;NIF3L1;TPCN1;ORAI1;CD247;SNX1;BAIAP2;L1CAM;ERN1 |
| ionotropic glutamate receptor binding | DLG4B;CANX;CACNG2;DLG2;FUS;SHANK1;RAB4A;NETO1;DLG1L |
| myosin V binding | RAB8A;FUS;RAB25;RAB3B;RAB11B;RAB10;RAB27B;RAB11A;RAB6B |
| nucleotide binding | DNAJC17;TLK1B;CKMT1;FYNB;NT5C3B;LMTK2;PRKCHB;RNPC3;BRAP |
| poly(A) RNA binding | RPL23A;RPS14;HERC5;SRSF11;DHX34;METAP2;RPS19BP1;DCAF13;EFTUD2 |
| protein binding | MBL2;TSSC4;MAL2;TRDN;CEP120;CAMK2B;CCDC47;UBASH3B;C22orf13 |
| retinoid X receptor binding | NR0B2;NR1H2;FUS;NRIP1;NCOA1;NCOR1;NR4A2;RARG;RARB |
| thyroid hormone receptor binding | ZNHIT3;MED12;GTF2B;TAF7;MED13;NCOA3;TAF11;MED4;MED16 |
| transcription coactivator activity | TUBB3;ABT1;CBFB;ECD;RB1;GTF2F1;ELF3;RNF14;TAF5L |
| zinc ion binding | TAB3;ZCCHC18;TET2;BIRC3;MICALL2A;MSL2;LHX8A;LMX1B;PIAS1 |
FUS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUS here. Most of them are supplied by our site. Hope this information will be useful for your research of FUS.
PLEC; EWSR1; TAF15; DROSHA; fus_ddit3
Research Area
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