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FUZ

  • Official Full Name

    fuzzy homolog

  • Synonyms

    FUZ; fuzzy homolog (Drosophila); protein fuzzy homolog; FLJ22688; Fy;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FUZ-6110HCL Recombinant Human FUZ 293 Cell Lysate HEK293 N/A
Human FUZ-5236HF Recombinant Full Length Human FUZ Protein, GST-tagged In Vitro Cell Free System GST 418 amino acids
Human FUZ-4571H Recombinant Human FUZ Protein, GST-tagged Wheat Germ GST
Mouse Fuz-3111M Recombinant Mouse Fuz Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat FUZ-2417R Recombinant Rat FUZ Protein Mammalian Cell His
Rat FUZ-2073R Recombinant Rat FUZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FUZ-2073R-B Recombinant Rat FUZ Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FUZ Related Articles

FUZ involved in several pathways and played different roles in them. We selected most pathways FUZ participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Double-Strand Break RepairPPP4R2A;EYA2;RAD51AP1;SMARCA5;PPP4R2;KIAA0146;BABAM1;HUS1;RAD50
DNA RepairPOLI;PPP4R2;RTEL1;ALKBH3;BRCC3;EYA4;CLSPN;RAD18;RNF168
Fanconi Anemia PathwayPALB2;ERCC1;CDK5R2;USP1;HER6;BRCA1;BRCA2;FANCM;PMS2
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)PPP4CB;EME1;RHNO1;TIPIN;BABAM1;TP53BP1;PPP4R2A;HUS1;FUZ
HDR through Homologous Recombination (HRR)HUS1;EME1;RAD51AP1;TOPBP1;RTEL1;RHNO1;KIAA0146;RAD9;WRN
Homologous recombinationCDK5R2;RAD51D;TOP3A;SYCP3;RPA1;XRCC2;RAD54L;RPA4;POLD4
Homology Directed RepairRAD51AP1;EME1;PPP4CA;KIAA0146;PPP4R2;RHNO1;WRN;EME2;PPP4CB

FUZ has several biochemical functions, for example, 3-flap endonuclease activity, DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUZ itself. We selected most functions FUZ had, and list some proteins which have the same functions with FUZ. You can find most of the proteins on our site.

Function Related Protein
3-flap endonuclease activityFUZ;MUS81
DNA bindingLIG3;KAT6A;RAD54B;TCEANC;HSF5;LIG4;SWAP70;RBPJA;FBXO21
metal ion bindingENDOG;BMP1B;GIT2A;MOB3C;ZFP551;OGDH;HAGHL;ZNF577;CA
protein bindingNR4A3;IGFBP7;LY6H;RMI1;ZNF193;IKBKG;CXorf41;FAM20C;ERCC1

FUZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUZ here. Most of them are supplied by our site. Hope this information will be useful for your research of FUZ.

RSG1

Brooks, ER; Wallingford, JB; et al. Multiciliated Cells. CURRENT BIOLOGY 24:R973-R982(2014).
Tabler, JM; Barrell, WB; et al. Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF related syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1888-1888(2014).
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