FYN
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Official Full Name
FYN oncogene related to SRC, FGR, YES
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Overview
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist. -
Synonyms
FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regu;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- GST|His
- His
- His (Fc)
- Avi
- His|T7
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | RAC3;PLCB3;PPP2R2C;GNAI1;BDKRB2;MAPK8;PLD1;SMPD1;BID |
| Phospholipase D signaling pathway | PIP5K1A;LPAR2;AVPR1B;PDGFD;CYTH4;PPAP2C;RRAS;PTK2B;PIK3CG |
| Axon guidance | DPYSL4;MYL12A;SEMA6B;COL9A1A;PAK4;SCN8A;SEMA3E;AP2S1;MAPK1 |
| Osteoclast differentiation | MAPK9;NOX3;PLCG2;IFNG;TNFRSF1A;MAPK8;SOCS3;CYBA;MAP3K7 |
| Focal adhesion | ITGA5;LAMA2;AKT1;PXN;VTNA;PIK3CG;MAPK1;ACTN3A;PAK1 |
| Adherens junction | TGFBR2;MAPK3;PTPRJA;INSRA;SMAD2;LEF1;YES1;FARP2;PTPRF |
| Platelet activation | PRKG1;ARHGAP35;MYLK2;COL27A1;AKT2;P2RY1;MAPK3;GP5;LYN |
| Natural killer cell mediated cytotoxicity | HRAS;FAS;IFNB1;RAET1E;KIR2DS5;SAMD3;PIK3R3;RAET1G;KIR2DL1 |
| T cell receptor signaling pathway | CD28;GSK3B;CBL;NFKB1;PRKCQ;MAPK12;PPP3CB;CDC42;VAV1 |
| Fc epsilon RI signaling pathway | MAPK10;RAF1;BTK;SYK;MAP2K3;IL4;PIK3R1;INPP5D;MAP2K6 |
| Cholinergic synapse | CREB3L3;SLC5A7;PIK3R3;GNAO1;CHRM5;PRKACG;KCNQ3;CAMK2G;ITPR3 |
| Prion diseases | NOTCH1;MAP2K2;C6;MAPK1;C9;LOC100033925;IL1A;NCAM1;C1QA |
| Pathogenic Escherichia coli infection | ACTB;KRT18;TUBAL3;ROCK2;ARHGEF2;YWHAZ;TLR5;ITGB1;WAS |
| Measles | HSPA8;STAT5B;GSK3B;HSPA1L;BBC3;STAT2;CCND1;CCNE2;IFNA7 |
| Viral myocarditis | SGCA;HLA-G;HLA-DMA;Casp3;CD86;HLA-A;ABL1;RAC2;H2-AB1 |
FYN has several biochemical functions, for example, ATP binding, CD4 receptor binding, CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX54;MCM8;MCCC1;UBE2T;ATP8A1;SGK3;KIF1B;CAMKVB;MAP2K5 |
| CD4 receptor binding | FYN;PLSCR1;SPG21;PLSCR4;LCK |
| CD8 receptor binding | LCK;FYN |
| G-protein coupled receptor binding | GNAI2B;PARK2;UTS2D;HSPA1A;GNAI2A;GNA14;CORT;AKAP5;INSL3 |
| T cell receptor binding | EPS8L1;H2-Q10;CD3E;CD1d1;DOCK2;CD3G;FYN;HLA-A |
| ephrin receptor binding | EFNA2A;ANKS1B;EFNB2;EFNA1B;GRB2;CDK5;EFNB2A;EFNA1;EFNA5 |
| glycoprotein binding | EDEM2;SERPINA1A;BMPR1A;RGMA;TFR2;BMPR1B;AZGP1;ITGA3;CALR |
| growth factor receptor binding | FYN;SLC9A3R1;SRC;APP |
| ion channel binding | CALM2;PRNP;ARRB1;HERPUD1;KCNAB1;NEDD4L;TCAP;PKP2;KCNC1 |
| metal ion binding | CYP3A25;CYP2C39;FIBCD1;ADAR;GBGT1;FAM164C;ZFP292;COL18A1;TPH1B |
| non-membrane spanning protein tyrosine kinase activity | MELK;PTK6B;JAK3;ITK;TNK1;ABL1;TNK2;WEE1;PTK6 |
| peptide hormone receptor binding | FYN;ADCYAP1;LEP;JAK2;RUNDC3A;PTPN11;PTHLHA;PTHLH;NPPC |
| phosphatidylinositol 3-kinase binding | INSRR;ATP1A1;TYRO3;IRS4;CALM1;HCST;BECN1;INSR;IRS1 |
| protein binding | FBXL8;ARR3;HGF;WLS;AKR1A1;NR2F2;TPD52L3;SCARB2;TUBGCP3 |
| protein tyrosine kinase activity | LTK;FYN;DYRK1A;LCK;PTK2BB;MAP3K9;KDR;KIT;EK1 |
| tubulin binding | MTAP7D3;CDK5RAP2;KIF14;TBCC;TTLL4;IFT81;STMN2A;STMN1;NCALD |
FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.
FYB; CBL; PRKCD; KHDRBS1
Gene Family
Research Area
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Customer Reviews (3)
Write a reviewthe manufacturer fosters scientific collaboration and knowledge sharing among researchers.
They can offer insights into interpreting results and assist in identifying trends or patterns that may be relevant to the specific research question.
This guarantees a continuous and uninterrupted availability of the protein for researchers, eliminating concerns about potential shortages or delays.
Q&As (5)
Ask a questionFYN protein is involved in regulating synaptic plasticity, which plays a crucial role in learning and memory.
Yes, FYN protein is also associated with cancer, particularly in regulating cell proliferation and survival.
Targeting FYN protein is being studied for its potential applications in the treatment of autoimmune diseases to modulate immune responses.
Some targeted therapies aimed at inhibiting FYN protein have been explored for specific types of cancer.
Yes, FYN protein levels can be measured in clinical settings through various laboratory techniques.
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