FYN

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FYN

Official Full Name FYN oncogene related to SRC, FGR, YES
Background This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist.
Synonyms FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regu
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FYN-1388H Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FYN-1766H Recombinant Human FYN protein, His & T7-tagged E.coli His/T7
    Human FYN-2128H Recombinant Human FYN Oncogene Related To SRC, FGR, YES, His-tagged Insect Cell His
    Human FYN-217H Recombinant Human FYN Oncogene Related To SRC, FGR, YES E.coli N/A
    Human FYN-2410H Recombinant Human FYN, GST-tagged E.coli GST
    Human FYN-28958TH Recombinant Human FYN N/A
    Human FYN-3213H Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FYN-322H Recombinant Human FYN, GST-tagged, Active Sf9 Insect Cell GST
    Human FYN-420H Recombinant Human FYN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human FYN-4585H Recombinant Human FYN Protein, GST/His-tagged Insect Cell GST/His
    Human FYN-4586H Recombinant Human FYN Protein, GST-tagged Wheat Germ GST
    Human FYN-50H Recombinant Human FYN protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human FYN-6091HCL Recombinant Human FYN 293 Cell Lysate HEK293 N/A
    Mouse Fyn-3119M Recombinant Mouse Fyn Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse FYN-6112M Recombinant Mouse FYN Protein Mammalian Cell His
    Rat FYN-2427R Recombinant Rat FYN Protein Mammalian Cell His
    Chicken FYN-6901C Recombinant Chicken FYN Mammalian Cell His

    FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway NFKB1; MAPK3; PPP2R2B; S1PR2; MAPK12; MAPK8; SGPP2; PPP2CA; GNAI2; PRKCG
    Phospholipase D signaling pathway PLA2G4D; Pdgfa&Pdgfb; CYTH2; AGPAT3; PIK3CD; HRAS; RAF1; PTGFR; AVPR2; GRM6
    Axon guidance MAPK1; EFNB3B; ARHGEF12; KDR; COL4A4; PEBP1; FGF18B; EPHB2; COL6A2; GNAI2
    Osteoclast differentiation MAPK10; IKBKB; PIK3CD; FCGR3B; TAB2; PIK3R3; MAPK3; LCP2; CYBB; AKT1
    Focal adhesion COMP; RAC1B; PDPK1B; CCND2; CCND1; PXN; PIK3CG; CCND2A; Reln; LAMA2
    Adherens junction RAC3B; RAC1A; PVRL3B; ACTB2; BAIAP2; MAP3K7; ACTN4; CSNK2A2A; PTPRF; INSRA
    Platelet activation Adcy4; FERMT3; LCP2; COL27A1; PRKCZ; PRKG2; TLN1; ROCK2; PLA2G4C; PIK3CG
    Natural killer cell mediated cytotoxicity MAP2K2; NFATC2; SHC2; TNFRSF10C; PPP3R1; KLRC3; TNFRSF10A; KIR2DS5; IFNA5; PTPN11
    T cell receptor signaling pathway RAF1; CD247; PTPRC; PRKCQ; ZAP70; AKT1; PAK1; BCL10; MAPK12; LAT
    Fc epsilon RI signaling pathway PIK3CA; VAV3; PLA2G4B; MAPK12; PIK3CB; FCER1G; PIK3R3; PDPK1; MAP2K6; MAPK1
    Cholinergic synapse CHRM2; MAP2K1; GNG8; GNG2; BCL2; ITPR1; KCNQ2; GNGT1; GNB2; AKR1C1
    Prion diseases MAPK3; STIP1; MAP2K1; PRNP; C6; SOD1; MAP2K2; C7; C1QA; CASP12
    Pathogenic Escherichia coli infection ARPC5L; YWHAZ; TUBAL3; TUBA1B; NCL; CD14; HCLS1; TUBA3C; ROCK2; TUBB6
    Measles TYK2; PIK3R3; CCND3; STAT2; CCNE1; TLR4; IFNAR2; TNFRSF10C; NFKB1; IFNA12
    Viral myocarditis Casp3; HLA-DOB; CD28; HLA-G; SGCD; HLA-F; MYH7; ITGB2L; HLA-DRB4; HLA-DOA

    FYN has several biochemical functions, for example, ATP binding, CD4 receptor binding, CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP1A3B; DHX36; WNK1; MAPKAPK5; ERBB3; GK5; PRPS2; CLPXA; TTK; ATP6V1A
    CD4 receptor binding LCK; PLSCR4; PLSCR1; FYN; SPG21
    CD8 receptor binding FYN; LCK
    G-protein coupled receptor binding QRFP; GHRL; FYN; ARRB2; USP20; GNAT3; POMC; HAND2; UCN3L; RSPO4
    T cell receptor binding CD1d1; DOCK2; H2-Q10; CD3E; EPS8L1; HLA-A; CD3G; FYN
    ephrin receptor binding SRC; SHC1; EFNB3; SIPA1L1; GRB2; EPHA7; PIK3CG; EFNA1; EFNB2; EFNB3B
    glycoprotein binding PIP; LGALS1; FBXO27; CNTN1; Itgam&Itgb2; Serpina1c; ERBB2; SERPINA1D; ITGAM; EDEM2
    growth factor receptor binding APP; SRC; SLC9A3R1; FYN
    ion channel binding RIMS1; PANX1; AASS; YES1; CIB1; FGF13; FAM115C; KCNH5; KCNH1; RANGRF
    metal ion binding YY1A; HCCS; OVOL3; ZNF830; ZNF362A; CELA1; ZFP385C; TRMT1; ZNF559-ZNF177; ACACB
    non-membrane spanning protein tyrosine kinase activity PTK2AB; TYK2; FYN; TXK; JAK3; PTK6B; SYK; ABL2; TNK2B; PKDCC
    peptide hormone receptor binding ADCYAP1; NPPA; PTH; PTHLH; PTPN11; FYN; PTHLHA; RUNDC3A; LEP; NPPC
    phosphatidylinositol 3-kinase binding JAK2; IRS1; ATP1A1; FLT3; INSRR; CALM1; DAB1; HCST; INSR; LCK
    protein binding PPIF; RMND5A; BCL7B; SUN1; CYB5R1; LOXL3; HNRNPF; ENG; SNX15; PPP6C
    protein tyrosine kinase activity SRMS; LCK; ERBB4; EPHA4B; KITA; ALK; FGFR1; EPHB4B; JAK2A; BLK
    tubulin binding AGTPBP1; CLIP1; MTAP7D3; BRCA1; STMN4; CENPJ; CDK5RAP2; PARK2; STMN2A; AGBL1

    FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.

    FYB; CBL; PRKCD; KHDRBS1

    Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
    Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).

    TGF

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