FYN
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Official Full Name
FYN oncogene related to SRC, FGR, YES -
Overview
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist. -
Synonyms
FYN;FYN oncogene related to SRC, FGR, YES;tyrosine-protein kinase Fyn;MGC45350;SLK;SYN;src-like kinase;proto-oncogene Syn;c-syn protooncogene;proto-oncogene c-Fyn;src/yes-related novel;tyrosine kinase p59fyn(T);OKT3-induced calcium influx regu
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Insect Cells
- Sf9 Cells
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- His
- Flag
- Non
- GST
- DDK
- Myc
- T7
- Avi
- Fc
Involved Pathway
FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway,Phospholipase D signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | IL4,IFNGR2,TLR4,TACR1,IFNA13,OAS2,STAT1,CCND1,TP53,PIK3CG |
| Platelet activation | MYLK2,PRKACB,MYLK,APBB1IP,PIK3CD,PPP1CA,GP5,MAPK11,PTGIR,ARHGEF12 |
| Sphingolipid signaling pathway | TRAF2,CERS2,RHOA,SGMS1,PPP2R5A,PPP2R1B,PIK3R2,PIK3R5,SMPD1,S1PR5 |
| Pathogenic Escherichia coli infection | NCL,ROCK2,RHOA,TUBA4A,TUBA8,NCK2,NCK1,ACTB,TUBA3D,HCLS1 |
| Fc epsilon RI signaling pathway | PLA2G4F,IL5,PIK3R1,KRAS,BTK,IL13,MAPK1,MAPK8,MAP2K6,MAPK9 |
| Natural killer cell mediated cytotoxicity | IFNA12,IFNA7,NCR1,RAC1,PRKCA,KIR2DL1,Casp3,VAV1,MICB,IFNA4 |
| Osteoclast differentiation | GAB2,BTK,FCGR1,MITF,SYK,LILRB4,FCGR4,IFNGR1,NFKB1,TNFRSF1A |
| T cell receptor signaling pathway | CD3E; CD3D,PIK3R1,SLA1,PIK3CG,NFATC1,TNF,FOS,NFKBIA,NFKBIE,RELA |
| Adherens junction | SMAD3,RHOAD,RHOAA,ACTB2,TGFBR1B,CTNND1,WASLA,MAPK3,FGFR1A,INSR |
Protein Function
FYN has several biochemical functions, for example, ATP binding,CD4 receptor binding,CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tubulin binding | AGBL1,BIRC5,TBCA,IFT81,TPPP3,STMN1A,STMN1,EML2,CDK5RAP2,MTAP7D3 |
| peptide hormone receptor binding | ADCYAP1,PTHLHA,LEP,PTHLH,RUNDC3A,NPPC,PTPN11,NPPA,PTH,JAK2 |
| metal ion binding | BTK,ZNF280B,ZNF215,SETDB1A,KCNH7,ZNF394,CYP7A1A,ZNF136,PM20D1.2,ADCY1 |
| protein tyrosine kinase activity | AXL,Aatk,LCK,MATK,NTRK2B,RET,INSRA,EGFRA,BMX,BCR |
| ATP binding | LRGUK,PTK2BB,DDX54,MARK3,TGFBR1B,ULK4,IPPK,CDC6,MYH10,PRKCHB |
| CD8 receptor binding | LCK |
| phosphatidylinositol 3-kinase binding | IRS2,IRS1,PIK3R1,INSRB,JAK2,IGF1RB,TYRO3,CALM2,INSRR,HCST |
| growth factor receptor binding | SLC9A3R1,SRC,APP |
| ion channel binding | CALM,PANX1,FAM115A,GRINA,PDE4D,KCNC1,KCNB2,CALM1,EPN1,PRKCSH |
Interacting Protein
FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.
FYB;CBL;PRKCD;KHDRBS1
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References
- Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
- Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).
