FYN

  • Official Full Name

    FYN oncogene related to SRC, FGR, YES
  • Overview

    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist.
  • Synonyms

    FYN;FYN oncogene related to SRC, FGR, YES;tyrosine-protein kinase Fyn;MGC45350;SLK;SYN;src-like kinase;proto-oncogene Syn;c-syn protooncogene;proto-oncogene c-Fyn;src/yes-related novel;tyrosine kinase p59fyn(T);OKT3-induced calcium influx regu

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • Insect Cells
  • Sf9 Cells
  • HEK293
  • In Vitro Cell Free System
  • Sf21 Cells
  • His
  • Flag
  • Non
  • GST
  • DDK
  • Myc
  • T7
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
FYN-0397H Recombinant Human FYN protein, His-tagged E.coli Human His 231-483 aa
FYN-822HFL Active Recombinant Full Length Human FYN Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
FYN-2128H Recombinant Human FYN Oncogene Related To SRC, FGR, YES, His-tagged Insect Cells Human His Full L.
FYN-217H Recombinant Human FYN Oncogene Related To SRC, FGR, YES E.coli Human Non
FYN-2410H Recombinant Human FYN, GST-tagged E.coli Human GST 23-216 a.a.
FYN-2427R Recombinant Rat FYN Protein Mammalian Cells Rat His
FYN-28958TH Recombinant Human FYN Human Non Full L.
FYN-322H Recombinant Human FYN, GST-tagged, Active Sf9 Cells Human GST
FYN-50H Recombinant Human FYN protein, Flag-tagged, Biotinylated Insect Cells Human Flag 1-537 a.a.
FYN-6112M Recombinant Mouse FYN Protein Mammalian Cells Mouse His
FYN-6901C Recombinant Chicken FYN Mammalian Cells Chicken His
FYN-6091HCL Recombinant Human FYN 293 Cell Lysate HEK293 Human Non
FYN-1388H Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
FYN-1766H Recombinant Human FYN protein, His & T7-tagged E.coli Human His&T7 Gly2~Leu537
FYN-2083R Recombinant Rat FYN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
FYN-2083R-B Recombinant Rat FYN Protein Pre-coupled Magnetic Beads HEK293 Rat
Fyn-3119M Recombinant Mouse Fyn Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
FYN-3213H Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
FYN-3407M Recombinant Mouse FYN Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FYN-3407M-B Recombinant Mouse FYN Protein Pre-coupled Magnetic Beads HEK293 Mouse
FYN-420H Recombinant Human FYN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
FYN-4585H Active Recombinant Human FYN Protein, GST/His-tagged Insect Cells Human GST&His
FYN-5284HF Recombinant Full Length Human FYN Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 482 amino acids
FYN-5832HF Active Recombinant Full Length Human FYN Protein, DDK-tagged, Biotinylated Sf21 Cells Human Flag Full L. 1-537(end)
FYN-7192HF Active Recombinant Full Length Human FYN Protein, GST-tagged Sf21 Cells Human GST Full L. 1-534(end)
FYN-8109HF Active Recombinant Full Length Human FYN Protein, GST-tagged Sf21 Cells Human GST Full L. 1-537(end)
FYN-949H Recombinant Human FYN Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
FYN-949H-B Recombinant Human FYN Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway,Phospholipase D signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathogenic Escherichia coli infection NCK2,WAS,TUBA3C,NCK1,TUBA1C,LY96,TUBA4A,NCL,RHOA,TUBB7P
    Phospholipase D signaling pathway ARF6,PIK3R5,LPAR4,DGKZ,PLD1,PIK3CG,PPAP2A,PLCB1,F2R,MAPK1
    Axon guidance PEA15A,JAK1,DPYSL4,MYL9,FRS3,GDNF,EPHA2,SRGAP1,CSNK2A1,EPHB4A
    Sphingolipid signaling pathway S1PR5,MAP3K5,MAPK1,PRKCA,PLCB3,RAF1,PLCB1,PRKCE,SGPP1,PPP2R2B
    Measles IFNGR1,RELA,SH2D1A,AKT2,TRAF6,OAS2,PRKCQ,IFNA8,PIK3R3,IL1B
    Osteoclast differentiation GAB2,BTK,NOX1,IFNG,MAP2K7,PIK3R5,SIRPB1,PPP3CC,IFNAR1,SFPI1
    Fc epsilon RI signaling pathway MAPK10,GM-CSF,BTK,MAP2K6,MS4A2,PIK3R5,MAP2K7,VAV3,PIK3R1,MAP2K3
    Adherens junction PTPRFB,RHOAD,FYNA,SSX2IPA,CDC42L2,VCLA,PVRL1B,CSNK2A1,SRC,IGF1RA
    T cell receptor signaling pathway NFATC1,GRB2,PTPRC,PIK3CA,SHB,PIK3R3,PAK2,PAK1,CD28,PPP3CA

    Protein Function

    FYN has several biochemical functions, for example, ATP binding,CD4 receptor binding,CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.

    Function Related Protein
    peptide hormone receptor binding LEP,RUNDC3A,PTPN11,NPPA,PTHLHA,NPPC,PTHLH,ADCYAP1,JAK2,PTH
    T cell receptor binding DOCK2,H2-Q10,CD3G,CD1d1,HLA-A,CD3E,EPS8L1
    non-membrane spanning protein tyrosine kinase activity TEC,PRKCD,YES1,JAK3,PKDCC,ZAP70,JAK1,PTK2BB,PTK2,TNK1
    CD8 receptor binding LCK
    metal ion binding ZFYVE9,TRIM67,CHN1,PHF2,SMPD4,PRKCHB,ACY3.2,CYP2N13,ZNF615,COL5A2
    ATP binding BBS12,KATNAL2,ABCC9,MAPK8B,MB21D1,ADCY3,MYH1E,ATP1A1A.2,QARS,HSPA1L
    protein binding RNF7,WARS,SNCG,CMTM2A,GNG10,ZGPAT,PHF20L1,NUBP2,TUBGCP3,ZNF133
    growth factor receptor binding SLC9A3R1,SRC,APP
    phosphatidylinositol 3-kinase binding IRS4,CORO1A,CALM3,INSRA,FLT3,ATP1A1,IGF1RA,BECN1,PDGFRB,IRS1

    Interacting Protein

    FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.

    FYB;CBL;PRKCD;KHDRBS1

    Resources

    References

    • Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
    • Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).

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